Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Shilpa Padmanaban"'
Autor:
Sherilyn Grill, Shilpa Padmanaban, Ann Friedman, Eric Perkey, Frederick Allen, Valerie M. Tesmer, Jennifer Chase, Rami Khoriaty, Catherine E. Keegan, Ivan Maillard, Jayakrishnan Nandakumar
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases known as telomeropathies. Telomerase is recruited to chromosome ends by the ACD/TPP1 protei
Externí odkaz:
https://doaj.org/article/5a3093082b6045328166fdcea15f594a
Publikováno v:
Life Science Alliance. 6:e202201727
Telomerase processively adds telomeric DNA repeats to chromosome ends using catalytic protein subunit TERT and a template on its RNA subunit TR. Mammalian telomerase is recruited to telomeres by the TEL patch and NOB regions of shelterin component TP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::060db26871f6acc727b894bbb6aef095
https://doi.org/10.26508/lsa.202201727
https://doi.org/10.26508/lsa.202201727
Publikováno v:
Proc Natl Acad Sci U S A
Telomerase catalyzes telomeric DNA synthesis at chromosome ends to allow for continued cell division. The telomeric protein TPP1 is essential for enhancing the processivity of telomerase and recruiting the enzyme to telomeres. The telomerase interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad56d0d8f1ebb1565dd26baac64e98cf
https://doi.org/10.1073/pnas.1911912116
https://doi.org/10.1073/pnas.1911912116
Autor:
Ann Friedman, Frederick Allen, Sherilyn Grill, Ivan Maillard, Shilpa Padmanaban, Jennifer Chase, Jayakrishnan Nandakumar, Valerie M. Tesmer, Rami Khoriaty, Catherine E. Keegan, Eric Perkey
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases known as telomeropathies. Telomerase is recruited to chromosome ends by the ACD/TPP1 protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993f6046bb8f8831b70ee16ba190b7a7
https://doi.org/10.1172/jci.insight.138059
https://doi.org/10.1172/jci.insight.138059
Autor:
Daniel J. DeAngelo, Donna Neuberg, Judy Garber, Mikko Myllymäki, Maxine M. Chen, Robert A. Redd, Suneet Agarwal, Valerie M. Tesmer, Frederick D. Tsai, Corey Cutler, Christopher R. Reilly, Shilpa Padmanaban, Stephen R. Spellman, Immaculata De Vivo, Christopher J. Gibson, Druha Karunakaran, Esther H. Orr, Jayakrishnan Nandakumar, Joseph H. Antin, Zhen-Huan Hu, R. Coleman Lindsley, Liang Zhong, Huma Q. Rana, Wael Saber
Publikováno v:
Blood. 138(10)
Germline pathogenic TERT variants are associated with short telomeres and an increased risk of developing myelodysplastic syndrome (MDS) among patients with a telomere biology disorder. We identified TERT rare variants in 41 of 1514 MDS patients (2.7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bab9581a916d59fd878f1cd65bf94f7
https://pubmed.ncbi.nlm.nih.gov/34499156
https://pubmed.ncbi.nlm.nih.gov/34499156