Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shilpa, Sambashivan"'
Autor:
Matthew Bratkowski, Tian Xie, Desiree A. Thayer, Shradha Lad, Prakhyat Mathur, Yu-San Yang, Gregory Danko, Thomas C. Burdett, Jean Danao, Aaron Cantor, Jennifer A. Kozak, Sean P. Brown, Xiaochen Bai, Shilpa Sambashivan
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107999- (2020)
Summary: The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) a
Externí odkaz:
https://doaj.org/article/313bc7f0c8174c0b846a7e9facf8f63c
Autor:
Marc R. Freeman, Shilpa Sambashivan
Publikováno v:
Curr Opin Neurobiol
Axon degeneration is a prominent feature of the injured nervous system, occurs across neurological diseases, and drives functional loss in neural circuits. We have seen a paradigm shift in the last decade with the realization that injured axons are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6829c7450e786a5727dbeb7339e99d72
https://doi.org/10.1016/j.conb.2021.05.004
https://doi.org/10.1016/j.conb.2021.05.004
Autor:
Dawn Weishuhn, Simone Brioschi, Diana Cha, Marco Colonna, Daniel Yoo, Sara Rao, Samuel A. Hasson, Jodi Bradley, Peng Luan, Ian Foltz, Shilpa Sambashivan, Shoutang Wang, Daniel C. Ellwanger, Menno Van Lookeren Campagne, Susan Gilfillan, Palaniswami Rathanaswami, Ryan Case, Lydia Green, Zhifei Shao
Publikováno v:
Proc Natl Acad Sci U S A
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ). Alzheimer’s disease (AD) risk is associated with the TREM2(R47H) variant, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e7e2a0334e1a0bf5f3ff55b8cfd453
https://doi.org/10.1073/pnas.2017742118
https://doi.org/10.1073/pnas.2017742118
Autor:
Santosh Talreja, Hang Chen, Danny Chui, Paul H. Wen, Songli Wang, Jean Danao, Shilpa Sambashivan, Jun Yin, Samir Koirala, Chi-Ming Li, David Tran, Qingwen Cheng, Ning Sun, Ian Foltz
Publikováno v:
Journal of Biological Chemistry. 293:12620-12633
Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. The rare variant R47H TREM2 is associated with an increased risk for Alzheimer's disease, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69decb1fcf6208c9397856e5993a4837
https://doi.org/10.1074/jbc.ra118.001848
https://doi.org/10.1074/jbc.ra118.001848
Autor:
Xiao Chen Bai, Desiree A. Thayer, Shilpa Sambashivan, Jean Danao, Tian Xie, Jennifer A. Kozak, Matthew Bratkowski, Prakhyat Mathur, Thomas C. Burdett, Sean P. Brown, Gregory Danko, Aaron Cantor, Shradha Lad, Yu San Yang
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107999-(2020)
Summary The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 A) and active SARM1 (6.8 A) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8e618a4c2c183c475c8680f4f7ad46
https://doi.org/10.1016/j.celrep.2020.107999
https://doi.org/10.1016/j.celrep.2020.107999
Autor:
Ai-Ching Lim, Jean Danao, Nikolai A. Sharkov, Steve Thibault, Songli Wang, Steve Wood, Edoardo Marcora, Santosh Talreja, Eric Bragg, Zhongqi Zhang, Jason Richardson, Ian Foltz, Rob Kegel, Hang Chen, Jodi Bradley, Xiaoshan Min, Shilpa Sambashivan, Zhulun Wang, Athena Sudom
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeef296643aab8b942f16b84784bc212
https://europepmc.org/articles/PMC6093241/
https://europepmc.org/articles/PMC6093241/
Autor:
Qingwen, Cheng, Jean, Danao, Santosh, Talreja, Paul, Wen, Jun, Yin, Ning, Sun, Chi-Ming, Li, Danny, Chui, David, Tran, Samir, Koirala, Hang, Chen, Ian N, Foltz, Songli, Wang, Shilpa, Sambashivan
Publikováno v:
The Journal of biological chemistry. 293(32)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. The rare variant R47H TREM2 is associated with an increased risk for Alzheimer's disease, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fb6d75683f871cfc59a96af475b98f0
https://pubmed.ncbi.nlm.nih.gov/29599291
https://pubmed.ncbi.nlm.nih.gov/29599291
Autor:
Shilpa Sambashivan
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccfde27ae5f882d838a497d9767a61fd
https://doi.org/10.1016/j.jalz.2017.07.603
https://doi.org/10.1016/j.jalz.2017.07.603
Publikováno v:
The Journal of Biological Chemistry
Background: A key step in intoxication by botulinum neurotoxins is the translocation of the protease domain by the translocation domain (TD) across endosomes. The requirements for translocation remain poorly understood. Results: A construct encompass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfeea6f55ae416d7e6dad260bf2650ca
https://doi.org/10.1074/jbc.c111.319400
https://doi.org/10.1074/jbc.c111.319400