Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Shili Xu"'
Autor:
Suhail Khoja, Jenna Lambert, Matthew Nitzahn, Adam Eliav, YuChen Zhang, Mikayla Tamboline, Colleen T. Le, Eram Nasser, Yunfeng Li, Puja Patel, Irina Zhuravka, Lindsay M. Lueptow, Ilona Tkachyova, Shili Xu, Itzhak Nissim, Andreas Schulze, Gerald S. Lipshutz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 278-296 (2022)
Creatine deficiency disorders are inborn errors of creatine metabolism, an energy homeostasis molecule. One of these, guanidinoacetate N-methyltransferase (GAMT) deficiency, has clinical characteristics that include features of autism, self-mutilatio
Externí odkaz:
https://doaj.org/article/87a7fdb6ecd04a129c24284a36c20cca
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/2547c224892842e893066ac1aa8bffdd
Autor:
Donald M. Lamkin, Shiuan Chen, Karen P. Bradshaw, Shili Xu, Kym F. Faull, Erica K. Sloan, Steve W. Cole
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The low-dose mixture hypothesis of carcinogenesis proposes that exposure to an environmental chemical that is not individually oncogenic may nonetheless be capable of enabling carcinogenesis when it acts in concert with other factors. A class of ubiq
Externí odkaz:
https://doaj.org/article/3f8dd2cda2e249f6ba1a55e8ed090ac5
Autor:
Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai, Harvey R. Herschman
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Background Precision medicine therapies require identification of unique molecular cancer characteristics. Hexokinase (HK) activity has been proposed as a therapeutic target; however, different hexokinase isoforms have not been well characte
Externí odkaz:
https://doaj.org/article/440363d204aa4ccf82544f27f7fe42b8
Autor:
Joseph P. Argus, Moses Q. Wilks, Quan D. Zhou, Wei Yuan Hsieh, Elvira Khialeeva, Xen Ping Hoi, Viet Bui, Shili Xu, Amy K. Yu, Eric S. Wang, Harvey R. Herschman, Kevin J. Williams, Steven J. Bensinger
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2919-2934.e8 (2018)
Summary: It is well understood that fatty acids can be synthesized, imported, and modified to meet requisite demands in cells. However, following the movement of fatty acids through the multiplicity of these metabolic steps has remained difficult. To
Externí odkaz:
https://doaj.org/article/482a607cb48f49f9b41f5484a29a328c
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an am
Externí odkaz:
https://doaj.org/article/60bac93b7d0d4ccbba58a39386a3ee0d
Autor:
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Ari Aycock-Williams, Michael B Cohen, Shili Xu, Nouri Neamati, Edward M Conway, Chieh-Yang Cheng, Alexander Yu Nikitin, Pradip Roy-Burman
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69484 (2013)
The inhibitor of apoptosis protein survivin is expressed in most cancers. Using the conditional PTEN deletion mouse model, we previously reported that survivin levels increase with prostate tumor growth. Here we evaluated the functional role of survi
Externí odkaz:
https://doaj.org/article/c1ef7a3f956e453586979acfa6a8e316
Autor:
Mingqi Han, Eric A. Bushong, Mayuko Segawa, Alexandre Tiard, Alex Wong, Morgan R. Brady, Milica Momcilovic, Dane M. Wolf, Ralph Zhang, Anton Petcherski, Matthew Madany, Shili Xu, Jason T. Lee, Masha V. Poyurovsky, Kellen Olszewski, Travis Holloway, Adrian Gomez, Maie St. John, Steven M. Dubinett, Carla M. Koehler, Orian S. Shirihai, Linsey Stiles, Aaron Lisberg, Stefano Soatto, Saman Sadeghi, Mark H. Ellisman, David B. Shackelford
Publikováno v:
Nature, vol 615, iss 7953
Acknowledgements: We thank C. Zamilpa, D. Abeydeera and J. Collins, at UCLA’s Crump Imaging Technology Center, for assistance with PET–CT imaging of the mice. We thank the Translational Pathology Core Laboratory at UCLA’s DGSOM for assistance w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ba0e060fdb5e0999dce8457473be4c
Interleukin (IL)-6 and Stat3 play key roles in ovarian cancer progression. However, the role of glycoprotein 130 (gp130), the signal transducer of this signaling axis, is not well-established. Currently, there are no small-molecule inhibitors of gp13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::977678c1585ac1b98621775c7483d99b
https://doi.org/10.1158/1535-7163.c.6536773.v1
https://doi.org/10.1158/1535-7163.c.6536773.v1