Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Shili Lin"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract An integration of 3D chromatin structure and gene expression at single-cell resolution has yet been demonstrated. Here, we develop a computational method, a multiomic data integration (MUDI) algorithm, which integrates scHi-C and scRNA-seq d
Externí odkaz:
https://doaj.org/article/1099ca1299724313a7d480ee26d86e3c
Autor:
Boyang Zhang, Shili Lin, Luis Moraes, Jeffrey Firkins, Alexander N. Hristov, Ermias Kebreab, Peter H. Janssen, André Bannink, Alireza R. Bayat, Les A. Crompton, Jan Dijkstra, Maguy A. Eugène, Michael Kreuzer, Mark McGee, Christopher K. Reynolds, Angela Schwarm, David R. Yáñez-Ruiz, Zhongtang Yu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Methane (CH4) emissions from ruminants are of a significant environmental concern, necessitating accurate prediction for emission inventories. Existing models rely solely on dietary and host animal-related data, ignoring the predicting power
Externí odkaz:
https://doaj.org/article/7e2d9a1b4d124d369879582869615c24
Autor:
Shuyuan Lou, Shili Lin
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0287521 (2024)
The ability to simulate high-throughput data with high fidelity to real experimental data is fundamental for benchmarking methods used to detect true long-range chromatin interactions mediated by a specific protein. Yet, such tools are not currently
Externí odkaz:
https://doaj.org/article/a02c8db69bd14f16ae92b3c0cc4f0188
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010129 (2022)
Single cell Hi-C techniques enable one to study cell to cell variability in chromatin interactions. However, single cell Hi-C (scHi-C) data suffer severely from sparsity, that is, the existence of excess zeros due to insufficient sequencing depth. Co
Externí odkaz:
https://doaj.org/article/c59f089cab6a40d6a25592b355d26b3b
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
In microbiome studies, researchers measure the abundance of each operational taxon unit (OTU) and are often interested in testing the association between the microbiota and the clinical outcome while conditional on certain covariates. Two types of ap
Externí odkaz:
https://doaj.org/article/00472cf8ae414ffcb3f07eb1388906de
Autor:
Yufan Zhou, Xiaolong Cheng, Yini Yang, Tian Li, Jingwei Li, Tim H.-M. Huang, Junbai Wang, Shili Lin, Victor X. Jin
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-13 (2020)
Abstract Current computational methods on Hi-C analysis focused on identifying Mb-size domains often failed to unveil the underlying functional and mechanistic relationship of chromatin structure and gene regulation. We developed a novel computationa
Externí odkaz:
https://doaj.org/article/176403df34b04d35838206edf577d3b6
Autor:
Virginia L. Ma, Shili Lin
Publikováno v:
Mathematical Biosciences and Engineering, Vol 17, Iss 1, Pp 73-91 (2020)
Many statistical methods for analyzing genetic data, such as those used in genome-wide association studies, assume Hardy-Weinberg Equilibrium (HWE). Therefore, to use such methods, one must check whether the HWE assumption is valid. For a case-contro
Externí odkaz:
https://doaj.org/article/9446742c6cd1415ab327dee617545a23
Publikováno v:
Mathematical Biosciences and Engineering, Vol 17, Iss 1, Pp 366-386 (2020)
Epigenetics is the study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence. Genomic imprinting is an epigenetically regulated process by which imprinted genes are expr
Externí odkaz:
https://doaj.org/article/abc67ae12636447497c951caadfb4cd0
Autor:
Yufan Zhou, Diana L. Gerrard, Junbai Wang, Tian Li, Yini Yang, Andrew J. Fritz, Mahitha Rajendran, Xiaoyong Fu, Gary Stein, Rachel Schiff, Shili Lin, Seth Frietze, Victor X. Jin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
In breast cancer, the 3D architecture of the genome can impact gene regulation. Here, the authors use tethered chromatin conformation profiling to investigate 3D chromatin structure in models of hormone-induced breast cancer and endocrine resistance,
Externí odkaz:
https://doaj.org/article/c168bfd68f6544dfa59367262175a08f
Publikováno v:
Complexity, Vol 2021 (2021)
Battery energy storage is the pivotal project of renewable energy systems reform and an effective regulator of energy flow. Parallel battery packs can effectively increase the capacity of battery modules. However, the power loss caused by the uncerta
Externí odkaz:
https://doaj.org/article/3fc66df944fe47e8a3fd37f3b30a9f40