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Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2467 (2023)
Low back pain is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is the primary clinical risk factor for low back pain and the pathological cause of disc herniation, spinal stenosis, and spinal deformity. A possible
Externí odkaz:
https://doaj.org/article/a7f274ff8e4a451f9af8754a37f90897
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
High-pressure injection injury of the hand is a rare but severe emergency, which requires full attention and timely treatment. However, the early symptoms may not be obvious. As the swelling and necrosis progress, the condition gradually worsens, and
Externí odkaz:
https://doaj.org/article/0e36d6fab1f04047972a4df5ca1d257b
Chronic lead poisoning induced abdominal pain and anemia: a case report and review of the literature
Publikováno v:
BMC Gastroenterology, Vol 20, Iss 1, Pp 1-5 (2020)
Abstract Background Chronic lead poisoning (CLP) is a rare cause of abdominal pain and is common in young children, in whom the incidence is higher than it is in adults. As the symptoms of CLP are nonspecific, misdiagnoses or missed diagnoses often o
Externí odkaz:
https://doaj.org/article/d32bf86d8fba478897ca5024483c1680
Autor:
Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level
Externí odkaz:
https://doaj.org/article/130018a3112a40a29ff505012c3352a4
Autor:
Qin Wu, David Heidenreich, Stanley Zhou, Suzanne Ackloo, Andreas Krämer, Kiran Nakka, Evelyne Lima-Fernandes, Genevieve Deblois, Shili Duan, Ravi N. Vellanki, Fengling Li, Masoud Vedadi, Jeffrey Dilworth, Mathieu Lupien, Paul E. Brennan, Cheryl H. Arrowsmith, Susanne Müller, Oleg Fedorov, Panagis Filippakopoulos, Stefan Knapp
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Bromodomains are conserved protein interaction modules that recognize acetyl-lysine modifications. Here the authors present a set of 25 selective small molecule inhibitors covering 29 human bromodomain targets and comprehensively evaluate the selecti
Externí odkaz:
https://doaj.org/article/6396da47b45340898d36418988b2a14e
Autor:
Evelyne Lima-Fernandes, Alex Murison, Tiago da Silva Medina, Yadong Wang, Anqi Ma, Cherry Leung, Genna M. Luciani, Jennifer Haynes, Aaron Pollett, Constanze Zeller, Shili Duan, Antonija Kreso, Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Daniel D. De Carvalho, Mathieu Lupien, Cheryl H. Arrowsmith, Catherine A. O’Brien
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiatin
Externí odkaz:
https://doaj.org/article/03a72eb189654119bb1c127366a2d06f
Publikováno v:
IEEE Access, Vol 7, Pp 126962-126972 (2019)
To get better control performance in motor control, more and more researches tend to apply non-linear control laws in the field of motor control. However, most conventional non-linear control theory is based on explicit model of controlled object and
Externí odkaz:
https://doaj.org/article/2646dbe9b9f14d9e9861cd045f945994
Autor:
Guorong Wen, Shili Deng, Wenfeng Song, Hai Jin, Jingyu Xu, Xuemei Liu, Rui Xie, Penghong Song, Biguang Tuo
Publikováno v:
BMC Microbiology, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background The pathogenesis of Helicobacter pylori (H. pylori) infection-induced duodenal ulcer remains to be elucidated. Duodenal mucosal bicarbonate secretion is the most important protective factor against acid-induced mucosal injury. We
Externí odkaz:
https://doaj.org/article/b56819f3c09941b88efc684669d11253
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 282 (2020)
Blood-pool agents (BPAs) are MRI contrast agents (CAs) characterized by their long circulation in the vascular system to provide an extended time window for high-resolution MR angiography (MRA). Prolonged vascular retention, however, impedes the excr
Externí odkaz:
https://doaj.org/article/04b5122075c549cbab93711d134f3b07