Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shilah A Bonnett"'
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0198059 (2018)
There is an urgent need for the development of shorter, simpler and more tolerable drugs to treat antibiotic tolerant populations of Mycobacterium tuberculosis. We previously identified a series of hydrazones active against M. tuberculosis. We select
Externí odkaz:
https://doaj.org/article/3453f07106684e82b63d51353970a009
Autor:
Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss, James Johnson, Aaron Korkegian, Steven Mullen, Abraham L. Moure, Susan H. Davis, Dinakaran Murugesan, Michael Mathieson, Nicola Caldwell, Curtis A. Engelhart, Dirk Schnappinger, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Laste Stojanovski, Lisa Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gail Freiberg, Dale J. Kempf, Thierry Masquelin, Philip A. Hipskind, Joshua Odingo, Kevin D. Read, Simon R. Green, Paul G. Wyatt, Tanya Parish
Publikováno v:
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
Externí odkaz:
https://doaj.org/article/0a27546e2eeb4807bfe33c85491f6518
Autor:
Shilah A. Bonnett, Alyssa B. Rosenbloom, Giang T. Ong, Mark Conner, Aric B.E. Rininger, Daniel Newhouse, Felicia New, Chi Q. Phan, Saskia Ilcisin, Hiromi Sato, John S. Lyssand, Gary Geiss, Joseph M. Beechem
Publikováno v:
Cancer Research Communications. 3:763-779
A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we present the development and implementation of a novel spatial pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78575f0b4ed76e36cb72cb2f060aa3dd
https://doi.org/10.1158/2767-9764.crc-22-0396
https://doi.org/10.1158/2767-9764.crc-22-0396
Autor:
Joseph M. Beechem, Gary Geiss, John S. Lyssand, Hiromi Sato, Saskia Ilcisin, Chi Q. Phan, Felicia New, Daniel Newhouse, Aric B.E. Rininger, Mark Conner, Giang T. Ong, Alyssa B. Rosenbloom, Shilah A. Bonnett
Assessment of SPG performance on human tissue. FFPE colorectal cancer sections were stained with the GeoMx NGS Human Protein modules (147-plex), WTA, and antibodies against PanCK (Tumor) and CD45 (Immune). A, Representative image of colorectal cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a9b8fed5af37b1a6af783232e1528e
https://doi.org/10.1158/2767-9764.22744306.v1
https://doi.org/10.1158/2767-9764.22744306.v1
Autor:
Joseph M. Beechem, Gary Geiss, John S. Lyssand, Hiromi Sato, Saskia Ilcisin, Chi Q. Phan, Felicia New, Daniel Newhouse, Aric B.E. Rininger, Mark Conner, Giang T. Ong, Alyssa B. Rosenbloom, Shilah A. Bonnett
SPG exploration of gcGBM and GBM. A, Representative images of ROIs segmented into CD45+, GFAP+, or CD45−/GFAP−. Top differentially expressed protein targets (B) and RNA targets (C) from frontal lobe gcGBM as compared with GBM, all grade 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3244643331736a94fd2d28816e17c518
https://doi.org/10.1158/2767-9764.22744294.v1
https://doi.org/10.1158/2767-9764.22744294.v1
Autor:
Joseph M. Beechem, Gary Geiss, John S. Lyssand, Hiromi Sato, Saskia Ilcisin, Chi Q. Phan, Felicia New, Daniel Newhouse, Aric B.E. Rininger, Mark Conner, Giang T. Ong, Alyssa B. Rosenbloom, Shilah A. Bonnett
Assessment of SPG data quality versus the respective RNA and Protein control data. Assay correlation with respect to the protein analyte comparing 147-plex and 59-plex protein panel (A), protein control and proteogenomic workflows (B), and user-to-us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33018253fb287fd1117a7c372aaca73f
https://doi.org/10.1158/2767-9764.22744309.v1
https://doi.org/10.1158/2767-9764.22744309.v1
Autor:
Joseph M. Beechem, Gary Geiss, John S. Lyssand, Hiromi Sato, Saskia Ilcisin, Chi Q. Phan, Felicia New, Daniel Newhouse, Aric B.E. Rininger, Mark Conner, Giang T. Ong, Alyssa B. Rosenbloom, Shilah A. Bonnett
DE analysis between GFAP- and CD45-enriched segments. A, Combined volcano plot resulting from the DE analysis between GFAP- and CD45-enriched segments for RNA (●) and protein (◆) analytes. Targets with significant DE are highlighted either orange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999646333a0d30c0d9514aaf76618150
https://doi.org/10.1158/2767-9764.22744297
https://doi.org/10.1158/2767-9764.22744297
Autor:
Joseph M. Beechem, Gary Geiss, John S. Lyssand, Hiromi Sato, Saskia Ilcisin, Chi Q. Phan, Felicia New, Daniel Newhouse, Aric B.E. Rininger, Mark Conner, Giang T. Ong, Alyssa B. Rosenbloom, Shilah A. Bonnett
Supplementary Table S1: A list of materials and reagents that are recommended for the GeoMx DSP assays that are not supplied by NanoString. Supplementary Table S2. A list of NanoString supplied materials and reagents. Supplementary Table S3: A list o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336ff1509cbab310eaeeadfe49e5685c
https://doi.org/10.1158/2767-9764.22744276
https://doi.org/10.1158/2767-9764.22744276
Autor:
Joseph M. Beechem, Gary Geiss, John S Lyssand, Hiromi Sato, Saskia Ilcisin, Chi Q. Phan, Felicia New, Daniel Newhouse, Aric BE Rininger, Mark Conner, Giang T Ong, Alyssa B Rosenbloom, Shilah A Bonnett
Supplementary Figure S19: Representative images used in the assessment of spatial proteogenomic data quality on Glioblastoma multiforme Grade 4. (A) Human brain glioblastoma tissue array was stained with the GeoMx NGS Human Protein modules (147-plex)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e3760508dd3733f744e5cc30a72361
https://doi.org/10.1158/2767-9764.22744282.v1
https://doi.org/10.1158/2767-9764.22744282.v1
Autor:
Joseph M. Beechem, Gary Geiss, John S. Lyssand, Hiromi Sato, Saskia Ilcisin, Chi Q. Phan, Felicia New, Daniel Newhouse, Aric B.E. Rininger, Mark Conner, Giang T. Ong, Alyssa B. Rosenbloom, Shilah A. Bonnett
SPG exploration of GBM grade 4. A, A total of 42 cores across 23 distinct sample sources and multiple GBM types. ROIs were segmented into CD45+, GFAP+, or CD45−/GFAP−. B, Statistics from a single slide and single GeoMx SPG run. UMAP plots for pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759ad3524bec66ab52efad1ff472241d
https://doi.org/10.1158/2767-9764.22744300.v1
https://doi.org/10.1158/2767-9764.22744300.v1