Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shila, Mekhoubad"'
Autor:
X. Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C. Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, H. Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D. Rubien, Karen Jansen-West, Casey N. Cook, Sarah Pickles, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, James Shorter, Sua Myong, Eric M. Green, William W. Seeley, Leonard Petrucelli, Aaron D. Gitler
Publikováno v:
Nature. 603:124-130
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f758b8c837195288f92794e856595a83
https://doi.org/10.1038/s41586-022-04424-7
https://doi.org/10.1038/s41586-022-04424-7
Autor:
X Rosa, Ma, Mercedes, Prudencio, Yuka, Koike, Sarat C, Vatsavayai, Garam, Kim, Fred, Harbinski, Adam, Briner, Caitlin M, Rodriguez, Caiwei, Guo, Tetsuya, Akiyama, H Broder, Schmidt, Beryl B, Cummings, David W, Wyatt, Katherine, Kurylo, Georgiana, Miller, Shila, Mekhoubad, Nathan, Sallee, Gemechu, Mekonnen, Laura, Ganser, Jack D, Rubien, Karen, Jansen-West, Casey N, Cook, Sarah, Pickles, Björn, Oskarsson, Neill R, Graff-Radford, Bradley F, Boeve, David S, Knopman, Ronald C, Petersen, Dennis W, Dickson, James, Shorter, Sua, Myong, Eric M, Green, William W, Seeley, Leonard, Petrucelli, Aaron D, Gitler
Publikováno v:
Nature, vol 603, iss 7899
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::821110b3bc35110fc73e4b0933142d1d
https://escholarship.org/uc/item/1062r1nd
https://escholarship.org/uc/item/1062r1nd
Autor:
Sulagna Ghosh, Seva Kashin, Shila Mekhoubad, Nissim Benvenisty, Kevin Eggan, Genevieve Saphier, Curtis J. Mello, Florian T. Merkle, Maura Charlton, Steven A. McCarroll, Yishai Avior, Nolan Kamitaki, Robert E. Handsaker, Shiran Bar, Jana M. Mitchell, Giulio Genovese, Dusko Ilic
Publikováno v:
Nature. 545:229-233
Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants that provide mutated cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ba175c9f08605c68303776a73807e9
https://doi.org/10.1038/nature22312
https://doi.org/10.1038/nature22312
Autor:
Patrick Cullen, John F. Staropoli, Shila Mekhoubad, Christina Fleet, Norm Allaire, Mohini Jangi, Adrian R. Krainer, John P. Carulli, Jessica A. Hurt, Shipra V. Gupta, C. Frank Bennett, Frank Rigo, Eric Chiao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(12)
Spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disease, is the leading monogenic cause of infant mortality. Homozygous loss of the gene survival of motor neuron 1 (SMN1) causes the selective degeneration of lower motor neurons an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798f924ec5f8818f23c3933a552307a4
https://pubmed.ncbi.nlm.nih.gov/28270613
https://pubmed.ncbi.nlm.nih.gov/28270613
Autor:
Zachary D. Smith, Michelle Chan, Alexander Meissner, Shila Mekhoubad, Rahul Karnik, Kathryn C. Humm, Aviv Regev, Kevin Eggan
Publikováno v:
PMC
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distributed across the genome, with local, cell-type-specific regulation directed by DNA binding factors. This comparatively static landscape is in marked co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0ae8be0839aa5e05f75042fa6b3715
https://doi.org/10.1038/nature13581
https://doi.org/10.1038/nature13581
Publikováno v:
Proceedings of the National Academy of Sciences. 105:4820-4825
With the potential to give rise to all somatic cell types, human embryonic stem cells (hESC) have generated enormous interest as agents of cell replacement therapy. One potential limitation is their safety in vivo . Although several studies have focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617a95b9e9be8209243f9a85b1537953
https://doi.org/10.1073/pnas.0712136105
https://doi.org/10.1073/pnas.0712136105
Autor:
Shila Mekhoubad, Evangelos Kiskinis, A. Sophie de Boer, Alexander Meissner, Christoph Bock, Kevin Eggan
Publikováno v:
Cell Stem Cell
SummaryAlthough distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0289a7ac4e27a468b0c956afcda327
https://europepmc.org/articles/PMC3603710/
https://europepmc.org/articles/PMC3603710/