Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shikui T"'
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Retrosynthetic planning, which aims to identify synthetic pathways for target molecules from starting materials, is a fundamental problem in synthetic chemistry. Computer-aided retrosynthesis has made significant progress, in which heuristic
Externí odkaz:
https://doaj.org/article/bb858dbf55194676b332fbbef312cd52
Publikováno v:
IET Signal Processing, Vol 2024 (2024)
Reinforcement learning (RL) has been applied to financial portfolio management in recent years. Current studies mostly focus on profit accumulation without much consideration of risk. Some risk-return balanced studies extract features from price and
Externí odkaz:
https://doaj.org/article/a8d012ce33524c98934d9eee53a31402
Autor:
Wenjun Chen, Jordan S. Brown, Tao He, Wei-Sheng Wu, Shikui Tu, Zhiping Weng, Donglei Zhang, Heng-Chi Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Phase separated, membrane-less germ granules preserve fertility and cellular function in animal germ cells. Here the authors show that loss of germ granules impacts piRNA pathway fidelity in the recognition of self and non-self nucleic acids.
Externí odkaz:
https://doaj.org/article/d8b863c6d92b413c8d5717dec515c6bb
Autor:
Peng Zhang, Shikui Tu
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010951 (2023)
Accurate prediction of synergistic effects of drug combinations can reduce the experimental costs for drug development and facilitate the discovery of novel efficacious combination therapies for clinical studies. The drug combinations with high syner
Externí odkaz:
https://doaj.org/article/455994a2ba02425a9ca43c30ac7f10a5
Autor:
Karla Leach, BS, Shikui Tang, PhD, Jared Sturgeon, MD, PhD, Andrew K. Lee, MD, Ryan Grover, MD, Parag Sanghvi, MD, James Urbanic, MD, Chang Chang, PhD
Publikováno v:
International Journal of Particle Therapy, Vol 8, Iss 1, Pp 50-61 (2021)
Purpose: A multi-field optimization (MFO) technique that uses beam-specific spot placement volumes (SPVs) and spot avoidance volumes (SAVs) is introduced for bilateral head and neck (H&N) cancers. These beam-specific volumes are used to guide the opt
Externí odkaz:
https://doaj.org/article/d8b11541d08545abac484c0cdc8ecef1
Autor:
Zhihao Xing, Shikui Tu
Publikováno v:
IEEE Access, Vol 8, Pp 108418-108428 (2020)
We tackle the classical traveling salesman problem (TSP) by combining a graph neural network and Monte Carlo Tree Search. We adopt a greedy algorithm framework to derive a promising tour by adding the vertices successively. A graph neural network is
Externí odkaz:
https://doaj.org/article/b1915931c97c43db99bf967202671ba7
Publikováno v:
IEEE Access, Vol 7, Pp 153751-153760 (2019)
Correct heartbeat classification from electrocardiogram (ECG) signals is fundamental to the diagnosis of arrhythmia. The recent advancement in deep convolutional neural network (CNN) has renewed the interest in applying deep learning techniques to im
Externí odkaz:
https://doaj.org/article/91086175e9c8488b81132087d7e73625
Autor:
Meetu Seth, Masaki Shirayama, Wen Tang, En-Zhi Shen, Shikui Tu, Heng-Chi Lee, Zhiping Weng, Craig C. Mello
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2254-2264 (2018)
Summary: Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regu
Externí odkaz:
https://doaj.org/article/734f1dd24ee44f19ba1286700306a1a0
Autor:
Gregory M Davis, Shikui Tu, Joshua WT Anderson, Rhys N Colson, Menachem J Gunzburg, Michelle A Francisco, Debashish Ray, Sean P Shrubsole, Julia A Sobotka, Uri Seroussi, Robert X Lao, Tuhin Maity, Monica Z Wu, Katherine McJunkin, Quaid D Morris, Timothy R Hughes, Jacqueline A Wilce, Julie M Claycomb, Zhiping Weng, Peter R Boag
Publikováno v:
eLife, Vol 7 (2018)
Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the C. elegans germline, a diverse repertoire of regulatory pathways promote the expression of endogenous germline genes and limit the expr
Externí odkaz:
https://doaj.org/article/02c779641e7847d38284aedcaf454370
Autor:
Gen Zhang, Shikui Tu, Tianxiong Yu, Xiao-Ou Zhang, Swapnil S. Parhad, Zhiping Weng, William E. Theurkauf
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3413-3422.e4 (2018)
Summary: In Drosophila, the piRNAs that guide germline transposon silencing are produced from heterochromatic clusters marked by the HP1 homolog Rhino. We show that Rhino promotes cluster transcript association with UAP56 and the THO complex, forming
Externí odkaz:
https://doaj.org/article/e31bb445f28c4d8f88ceacdf809f6d65