Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Shikha Nayar"'
Autor:
Joshua K. Morrison, Charles DeRossi, Isaac L. Alter, Shikha Nayar, Mamta Giri, Chi Zhang, Judy H. Cho, Jaime Chu
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1711-1724 (2022)
Abstract The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been an underutilized tool to study liver fibrosis. We aimed to characterize the single
Externí odkaz:
https://doaj.org/article/90d3554613be407b84521a45ffda51e0
Autor:
Shikha Nayar, Judy H. Cho
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103690- (2021)
The mainstay of moderate to severe Crohn's disease (CD), anti-TNF treatment, shows no clinical benefit in ∼40% of patients, likely due to incomplete cellular targeting and delayed treatment institution. While single-target therapeutics have been hi
Externí odkaz:
https://doaj.org/article/2edd0d56275e427b91380fd2fdfcbd3a
Autor:
Shikha Nayar, S V Madhu
Publikováno v:
Indian Journal of Endocrinology and Metabolism, Vol 24, Iss 3, Pp 251-255 (2020)
Introduction: Wheat is preferable over rice due to its lower glycemic index (GI). It is not known if the same is true when these staples are a part of mixed meals, hence we compared the Glycemic responses of wheat/rice containing mixed meals. Materia
Externí odkaz:
https://doaj.org/article/5d2ae6fc25354905baa30195425a8775
Autor:
Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 8 (2019)
Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput in viv
Externí odkaz:
https://doaj.org/article/92af79db91ab40a9b37d8885cb233256
Autor:
Nataly Shtraizent, Charles DeRossi, Shikha Nayar, Ravi Sachidanandam, Liora S Katz, Adam Prince, Anna P Koh, Adam Vincek, Yoav Hadas, Yujin Hoshida, Donald K Scott, Efrat Eliyahu, Hudson H Freeze, Kirsten C Sadler, Jaime Chu
Publikováno v:
eLife, Vol 6 (2017)
Rapid cellular proliferation in early development and cancer depends on glucose metabolism to fuel macromolecule biosynthesis. Metabolic enzymes are presumed regulators of this glycolysis-driven metabolic program, known as the Warburg effect; however
Externí odkaz:
https://doaj.org/article/2d882b0e6ea14d7787b09ec9d5be2a23
Autor:
Nai-Yun Hsu, Shikha Nayar, Kyle Gettler, Sayali Talware, Mamta Giri, Isaac Alter, Carmen Argmann, Ksenija Sabic, Tin Htwe Thin, Huai-Bin Mabel Ko, Robert Werner, Christopher Tastad, Thaddeus Stappenbeck, Aline Azabdaftari, Holm H Uhlig, Ling-Shiang Chuang, Judy H Cho
Publikováno v:
Gut. 72:654-662
ObjectiveLoss-of-function mutations in genes generating reactive oxygen species (ROS), such asNOX1, are associated with IBD. Mechanisms whereby loss of ROS drive IBD are incompletely defined.DesignROS measurements and single-cell transcriptomics were
Autor:
Yuval Itan, Mark S. Silverberg, Steven R. Brant, Ujunwa M. Korie, Aayushee Jain, Inga Peter, Shikha Nayar, Ling-Shiang Chuang, Talin Haritunians, Ksenija Sabic, John D. Rioux, Gerardus Bongers, Nicole Villaverde, Colleen C. Chasteau, Arden Moscati, Richard H. Duerr, Ernie Chen, Nai Yun Hsu, Tin Htwe Thin, Judy H. Cho, Sari Joshowitz, Isaac L. Alter, Siarhei Dzedzik, Zhi Chai, Mamta Giri, Kyle Gettler, L. Philip Schumm, Dermot P.B. McGovern
Publikováno v:
Gastroenterology
Background & Aims Recent literature has implicated a key role for mast cells in murine models of colonic inflammation, but their role in human ulcerative colitis (UC) is not well established. A major advance has been the identification of mrgprb2 (hu
Autor:
Shadi Nayeri, Dermot P.B. McGovern, Mamta Giri, Richard H. Duerr, Cristian Hernandez-Rocha, Jiayi Ji, Shikha Nayar, Ksenija Sabic, Steven R. Brant, Mark S. Silverberg, Phil Schumm, Margaret Walshe, Mark Lazarev, Liangyuan Hu, Judy H. Cho, John D. Rioux
Publikováno v:
J Crohns Colitis
Background and Aims Crohn’s disease [CD] recurrence following ileocolic resection [ICR] is common. We sought to identify blood-based biomarkers associated with CD recurrence. Methods CD patients undergoing ICR were recruited across six centres. Ser
Autor:
Judy H. Cho, Joshua Morrison, Jaime Chu, Chi Zhang, Charles DeRossi, Mamta Giri, Shikha Nayar, Isaac L. Alter
Liver fibrosis is the excessive accumulation of extracellular matrix that can progress to cirrhosis and failure if untreated (1). The mechanisms of fibrogenesis are multi-faceted and remain elusive with no approved antifibrotic treatments available (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::747fe908c1a749f9cf30c2524ee44e9f
https://doi.org/10.1101/2021.08.06.455422
https://doi.org/10.1101/2021.08.06.455422
Autor:
Jaime Chu, Kyle Gettler, Miriam Merad, Huaibin M. Ko, Laura Walker, Shikha Nayar, Judy H. Cho, Mamta Giri, Subra Kugathasan, Joshua Morrison, Ling-Shiang Chuang, Ephraim Kenigsberg
Publikováno v:
Nature
Crohn's disease is a chronic inflammatory intestinal disease that is frequently accompanied by aberrant healing and stricturing complications. Crosstalk between activated myeloid and stromal cells is critical in the pathogenicity of Crohn's disease1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69babe346cc13e010b7c40477501f0d9
https://europepmc.org/articles/PMC8284870/
https://europepmc.org/articles/PMC8284870/