Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Shijun Wen"'
Autor:
Mengqi Yang, Jiaxin Liu, Jianan Li, Shijun Wen, Yumin Hu, Wenhua Lu, Jinyun Liu, Peng Huang, Panpan Liu
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103245- (2024)
Since the survival of lymphoma patients who experience disease progression or relapse remains very poor, new therapeutic approaches and effective drugs are urgently needed. Here we show that auranofin (AF), an anti-rheumatoid drug thought to inhibit
Externí odkaz:
https://doaj.org/article/3dd33dfbec784a21b763548c4cf6e84b
Autor:
Jiang-jiang Li, Tiantian Yu, Peiting Zeng, Jingyu Tian, Panpan Liu, Shuang Qiao, Shijun Wen, Yumin Hu, Qiao Liu, Wenhua Lu, Hui Zhang, Peng Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mutations in isocitrate dehydrogenases (IDH) are oncogenic events due to the generation of oncogenic metabolite 2-hydroxyglutarate. However, the role of wild-type IDH in cancer development remains elusive. Here we show that wild-type IDH2 is
Externí odkaz:
https://doaj.org/article/ff8b8155af5c47038fa51f45d4a09483
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Mitochondria are promising drug target for cancer treatment. We previously demonstrated that a bi-gold compound BGC2a was more potent than the mono-gold drug auranofin in suppressing cancer cells due to increased gold atom number that led to higher d
Externí odkaz:
https://doaj.org/article/c19827921137433ea5c15bb0b312c67d
Autor:
Jianfeng Chen, Jing Han Hong, Yulin Huang, Shini Liu, Jiaxin Yin, Peng Deng, Yichen Sun, Zhaoliang Yu, Xian Zeng, Rong Xiao, Jason Yongsheng Chan, Peiyong Guan, Yali Wang, Peili Wang, Lizhen Liu, Shijun Wen, Qiang Yu, Choon Kiat Ong, Bin-Tean Teh, Ying Xiong, Jing Tan
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background Enhancer of zeste homolog 2 (EZH2), the key catalytic subunit of polycomb repressive complex 2 (PRC2), is overexpressed and plays an oncogenic role in various cancers through catalysis-dependent or catalysis-independent pathways.
Externí odkaz:
https://doaj.org/article/b67020e61b6748208cb6b5f34e466c59
Autor:
Peiting Zeng, Wenhua Lu, Jingyu Tian, Shuang Qiao, Jiangjiang Li, Christophe Glorieux, Shijun Wen, Hui Zhang, Yiqing Li, Peng Huang
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-22 (2022)
Abstract Background Isocitrate dehydrogenase-2 (IDH2) is a mitochondrial enzyme that catalyzes the metabolic conversion between isocitrate and alpha-ketoglutarate (α-KG) in the TCA cycle. IDH2 mutation is an oncogenic event in acute myeloid leukemia
Externí odkaz:
https://doaj.org/article/b4e0b36914e841f693d11684c14dc61a
Autor:
Ailin Chen, Shijun Wen, Fang Liu, Zijian Zhang, Meiling Liu, Yuanzhong Wu, Bin He, Min Yan, Tiebang Kang, Eric W‐F Lam, Zifeng Wang, Quentin Liu
Publikováno v:
Cancer Communications, Vol 41, Iss 2, Pp 121-139 (2021)
Abstract Background Overexpression of Aurora‐A (AURKA) is a feature of breast cancer and associates with adverse prognosis. The selective Aurora‐A inhibitor alisertib (MLN8237) has recently demonstrated promising antitumor responses as a single a
Externí odkaz:
https://doaj.org/article/a3afe89385ea40779bb1c94a14f4e126
Autor:
Xin You, Jingyu Tian, Hui Zhang, Yunhua Guo, Jing Yang, Chaofeng Zhu, Ming Song, Peng Wang, Zexian Liu, John Cancilla, Wenhua Lu, Christophe Glorieux, Shijun Wen, Hongli Du, Peng Huang, Yumin Hu
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101203- (2021)
Objective: Mitochondrial aconitase (ACO2) is an essential enzyme that bridges the TCA cycle and lipid metabolism. However, its role in cancer development remains to be elucidated. The metabolic subtype of colorectal cancer (CRC) was recently establis
Externí odkaz:
https://doaj.org/article/2c7a9a6ea3f74273b314f1ac9491312b
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6106-6113 (2019)
Externí odkaz:
https://doaj.org/article/60e7df3b71b64d2fa5c9bcc70235e6c7
Autor:
Xin You, Weiye Jiang, Wenhua Lu, Hui Zhang, Tiantian Yu, Jingyu Tian, Shijun Wen, Guillermo Garcia-Manero, Peng Huang, Yumin Hu
Publikováno v:
Cancer Communications, Vol 39, Iss 1, Pp 1-13 (2019)
Abstract Background Internal tandem duplications (ITD) within the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3) represent a poor prognostic indicator in acute myeloid leukemia (AML). Therapeutic benefits of tyrosine kinase inhibitors, suc
Externí odkaz:
https://doaj.org/article/4fcf51fc717a4196ab0a806773966c29
Autor:
Zhen Long Ng, Jiamin Siew, Jia Li, Guanxu Ji, Min Huang, Xiaohua Liao, Sue Yu, Yuanyuan Chew, Chin Wen Png, Yongliang Zhang, Shijun Wen, Henry Yang, Yiting Zhou, Yun Chau Long, Zhi Hong Jiang, Qiang Wu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Liver cancer is the third most common cause of cancer death in the world. POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1/MAZR) is a transcription factor associated with various cancers. However, the role of PATZ1 in cancer progression re
Externí odkaz:
https://doaj.org/article/47a1f535243f4ded815f01c5626b4e05