Výsledky vyhledávání - "Shihou Murakami"

Akademický článek

Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients

Autor: Minoru Iwata, Yutaka Kamura, Hisae Honoki, Kaori Kobayashi, Manabu Ishiki, Kunimasa Yagi, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuhito Fukuda, Yukiko Koshimizu, Kazuyuki Tobe

Publikováno v: Journal of Diabetes Investigation, Vol 11, Iss 3, Pp 564-572 (2020)

Abstract Aims/Introduction The objective of the present study was to clarify the association of the type and number of first‐degree family history of diabetes (FHD) with the clinical characteristics, especially with residual β‐cell function, in

Externí odkaz: https://doaj.org/article/a1720d67a2264891be24049d604b4eaf

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Akademický článek

Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.

Autor: Minoru Iwata, Kazuo Hara, Yutaka Kamura, Hisae Honoki, Shiho Fujisaka, Manabu Ishiki, Isao Usui, Kunimasa Yagi, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuhito Fukuda, Yukiko Koshimizu, Kazuyuki Tobe

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0192609 (2018)

Among the three adiponectin isoforms, a lower ratio of high molecular weight (HMW) adiponectin to total adiponectin (TA) is well known to cause insulin resistance and type 2 diabetes (T2D). However, how the levels of other adiponectin isoforms, such

Externí odkaz: https://doaj.org/article/4a48fa4938c246759ae6aeb1ba5d4cec

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Akademický článek

FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.

Autor: Yutaka Kamura, Minoru Iwata, Shiro Maeda, Satomi Shinmura, Yukiko Koshimizu, Hisae Honoki, Kazuhito Fukuda, Manabu Ishiki, Isao Usui, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuyuki Tobe

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165523 (2016)

Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However, whether the effects of the FTO locus on T2D susceptibility are independent of fat-mass incr

Externí odkaz: https://doaj.org/article/41077e01667841539abdaeaf332fe035

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Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients

Autor: Kazuhito Fukuda, Hisae Honoki, Yukiko Koshimizu, Yasuo Fukushima, Kiyohiro Higuchi, Kaori Kobayashi, Shihou Murakami, Yutaka Kamura, Kunimasa Yagi, Manabu Ishiki, Chikaaki Kobashi, Kazuyuki Tobe, Hiromi Kato, Minoru Iwata, Atsuko Takano

Publikováno v: Journal of Diabetes Investigation, Vol 11, Iss 3, Pp 564-572 (2020)
Journal of Diabetes Investigation

Aims/Introduction The objective of the present study was to clarify the association of the type and number of first‐degree family history of diabetes (FHD) with the clinical characteristics, especially with residual β‐cell function, in type 2 di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5919f9ad8149ab77302f7f5b943d18
https://doaj.org/article/a1720d67a2264891be24049d604b4eaf

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Dual Role of Src Homology Domain 2-Containing Inositol Phosphatase 2 in the Regulation of Platelet-Derived Growth Factor and Insulin-Like Growth Factor I Signaling in Rat Vascular Smooth Muscle Cells

Autor: Toshiyasu Sasaoka, Rina Aota, Kosei Kikuchi, Hajime Ishihara, Ikuko Kimura, Shihou Murakami, Kazuhito Fukui, Masashi Kobayashi, Tsutomu Wada, Akira Sato, Hiroyuki Hori

Publikováno v: Endocrinology. 144:4204-4214

Src homology domain 2 (SH2)-containing inositol phosphatase 2 (SHIP2) possesses 5-phosphatase activity and an SH2 domain. The role of SHIP2 in platelet-derived growth factor (PDGF) and IGF-I signaling was studied by expressing wild-type (WT-) and a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45198ab3af1c553e4aed2b03de9cc316
https://doi.org/10.1210/en.2003-0190

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Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice

Autor: Hajime Ishihara, Tsutomu Wada, Manabu Ishiki, Masashi Kobayashi, Toshiyasu Sasaoka, Hiroyuki Hori, Shihou Murakami

Publikováno v: Diabetes. 51:2387-2394

SH-2-containing inositol 5′-phosphatase 2 (SHIP-2) is a physiologically important lipid phosphatase that functions to hydrolyze phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4adcd7db299eb0aeb0fb797f9343d630
https://doi.org/10.2337/diabetes.51.8.2387

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Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5′-Phosphatase Catalytic Activity

Autor: Shihou Murakami, Tomoichiro Asano, Tetsuro Haruta, Manabu Ishiki, Hajime Ishihara, Hiroyuki Hori, Masashi Kobayashi, Wataru Ogawa, Tsutomu Wada, Makoto Funaki, Toshiyasu Sasaoka

Publikováno v: Molecular and Cellular Biology. 21:1633-1646

Insulin binding to the extracellular α subunit of the insulin receptor activates the intrinsic tyrosine kinase activity of the intracellular β subunit. The activated insulin receptor phosphorylates the insulin receptor substrate (IRS) family of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bef98ef490ed86a45eb7fafd7936a7
https://doi.org/10.1128/mcb.21.5.1633-1646.2001

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FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men

Autor: Minoru Iwata, Atsuko Takano, Satomi Shinmura, Kazuhito Fukuda, Manabu Ishiki, Isao Usui, Shihou Murakami, Yukiko Koshimizu, Hiromi Kato, Shiro Maeda, Yutaka Kamura, Kazuyuki Tobe, Hisae Honoki, Kiyohiro Higuchi, Chikaaki Kobashi, Yasuo Fukushima

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165523 (2016)
PLoS ONE

Aim Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However, whether the effects of the FTO locus on T2D susceptibility are independent of fat-mass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d139fd75e08e456d5c4f0f9ff3791ca
https://doi.org/10.1371/journal.pone.0165523

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Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling

Autor: Hiroshi Tsuneki, Soushi Kobayashi, Toshiyasu Sasaoka, Kazuhito Fukui, Tsutomu Wada, Hajime Ishihara, Saori Yaguchi, Masashi Kobayashi, Syota Kagawa, Ikuko Kimura, Shihou Murakami

Publikováno v: The Journal of clinical endocrinology and metabolism. 90(5)

Src homology 2-containing 5'-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745927e22900dd65b6772a1050b784ac
https://pubmed.ncbi.nlm.nih.gov/15687335

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