Výsledky vyhledávání - "Shihori Hattori"

Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H

Autor: Yoshiaki Masaki, Ayano Tabira, Shihori Hattori, Shunsuke Wakatsuki, Kohji Seio

Publikováno v: Organicbiomolecular chemistry. 20(45)

RNase H acts as a key effector in gene knockdown by antisense oligonucleotides (ASOs). Although various chemical modifications have been developed to regulate RNase H-mediated cleavage, precise control is yet to be achieved. In this study, we tried t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d634d569d8bb6549eaa13de55ac827f
https://pubmed.ncbi.nlm.nih.gov/36321625

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