Synthesis and In Vitro Antiproliferative Activity of 11-Substituted Neocryptolepines with a Branched ω-Aminoalkylamino Chain

Autor: Elkhabiry Shaban, Marta Świtalska, Li Wang, Ning Wang, Fan Xiu, Ikuya Hayashi, Tran Anh Ngoc, Sachie Nagae, Samah El-Ghlban, Shiho Shimoda, Ahmed Abdel Aleem El Gokha, Ibrahim El Tantawy El Sayed, Joanna Wietrzyk, Tsutomu Inokuchi

Publikováno v: Molecules, Vol 22, Iss 11, p 1954 (2017)

Neocryptolepine, which is a kind of tetracyclic indoloquinoline alkaloid, exhibits the inhibition of topoisomerase II and shows antiproliferative activity. The present study describes the synthesis and antiproliferative evaluation of several neocrypt

Externí odkaz: https://doaj.org/article/2ef95abd1b3b4848aad0dd1d32cacde8

Synthesis and In Vitro Antiproliferative Activity of 11-Substituted Neocryptolepines with a Branched ω-Aminoalkylamino Chain

Autor: Ahmed A. El Gokha, Shiho Shimoda, Ning Wang, Ikuya Hayashi, Fan Xiu, Sachie Nagae, Joanna Wietrzyk, Ibrahim El Tantawy El Sayed, Tran Anh Ngoc, Marta Świtalska, Li Wang, Elkhabiry Shaban, Samah El-Ghlban, Tsutomu Inokuchi

Publikováno v: Molecules; Volume 22; Issue 11; Pages: 1954
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 11, p 1954 (2017)

Neocryptolepine, which is a kind of tetracyclic indoloquinoline alkaloid, exhibits the inhibition of topoisomerase II and shows antiproliferative activity. The present study describes the synthesis and antiproliferative evaluation of several neocrypt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9afea752a9fbec0962107f9e056ba6