Výsledky vyhledávání - "Shihao Shangguan"

Akademický článek

Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenylbenzamide Derivatives as BACE-1 Inhibitors

Autor: Lushan Yu, Yongzhou Hu, Rong Sheng, Haiping Yu, Jia Li, Wenhai Huang, Haihong Hu, Yong Liao, Fei Wang, Shihao Shangguan

Publikováno v: Molecules, Vol 18, Iss 3, Pp 3577-3594 (2013)

Three series of 3-(2-aminoheterocycle)-4-benzyloxyphenylbenzamide derivatives, 2-aminooxazoles, 2-aminothiazoles, and 2-amino-6H-1,3,4-thiadizines were designed, synthesized and evaluated as β-secretase (BACE-1) inhibitors. Preliminary structure-act

Externí odkaz: https://doaj.org/article/c403f6ce321a4703ac6fc08de47762b2

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Akademický článek

Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives as Hypoxic Selective Anti-tumor Agents

Autor: Yongzhou Hu, Rong Sheng, Xiaowen Liu, Shihao Shangguan, Qing Xia, Yunzhen Hu

Publikováno v: Molecules, Vol 17, Iss 8, Pp 9683-9696 (2012)

A series of 3-aryl-2-quinoxaline-carbonitrile 1,4-di-N-oxide derivatives were designed, synthesized and evaluated for hypoxic and normoxic cytotoxic activity against human SMMC-7721, K562, KB, A549 and PC-3 cell lines. Many of these new compounds dis

Externí odkaz: https://doaj.org/article/affb59336c344fe1acc8c964e00223ba

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Novel potent HIF-1 inhibitors for the prevention of tumor metastasis: discovery and optimization of 3-aryl-5-indazole-1,2,4-oxadiazole derivatives

Autor: Rong Sheng, Ni Qiu, Shan Li, Qiaojun He, Yongzhou Hu, Yongchuan Gu, Shihao Shangguan, Ji Cao, Bo Yang, Guanyu Lin

Publikováno v: RSC Advances. 5:81817-81830

Hypoxia inducible factor-1 (HIF-1) is the key transcription factor of cellular response to hypoxia and plays a critical role in tumor metastasis. We describe here the discovery and a structure–activity relationship study of a series of 3-aryl-5-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::738bb13bd92f95cf0c3f7cd4ed58ea91
https://doi.org/10.1039/c5ra15191k

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Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenylbenzamide Derivatives as BACE-1 Inhibitors

Autor: Fei Wang, Jia Li, Wenhai Huang, Yong Liao, Haiping Yu, Haihong Hu, Shihao Shangguan, Lushan Yu, Rong Sheng, Yongzhou Hu

Publikováno v: Molecules, Vol 18, Iss 3, Pp 3577-3594 (2013)
Molecules
Molecules; Volume 18; Issue 3; Pages: 3577-3594

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8b7271fb4dd0233437dec93a91270e
http://www.mdpi.com/1420-3049/18/3/3577

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[Current quality management situation and administration countermeasure study of enterprises marketing corneal contact lens]

Autor: Yungui, Liu, Ying, Yao, Shihao, Shangguan, Qun, Gu, Wuming, Gao, Yaoshui, Chen

Publikováno v: Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation. 38(3)

Study the current quality management situation of enterprises marketing corneal contact lens via systemic investigations and explore effective administration countermeasures in the future.The quality management indicators of sixty-two corneal contact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c38bf6c71e47f32d6b25ec11b82580d
https://pubmed.ncbi.nlm.nih.gov/25241520

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Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors

Autor: Haoshu Wu, Jia Li, Meimei Si, Yang Liu, Yongzhou Hu, Tao Liu, Peng Wu, Li Tang, Shihao Shangguan, Xiaodong Ma

Publikováno v: Bioorganicmedicinal chemistry. 21(18)

A series of novel benzyl-substituted (S)-phenylalanine derivatives were synthesized and evaluated for their dipeptidyl peptidase 4 (DPP-4) inhibitory activity and selectivity. It was found that most synthesized target compounds were potent DPP-4 inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20dfeab0d243abac959a04f14a23bba
https://pubmed.ncbi.nlm.nih.gov/23938053

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Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53-MDM2 interaction. Part 1

Autor: Weisi Wang, Lei Zhang, Yongzhou Hu, Chunqi Hu, Ni Qiu, Shihao Shangguan

Publikováno v: Bioorganicmedicinal chemistry. 21(11)

A series of 3,4,5-trisubstituted aminothiophenes were designed, synthesized, and evaluated for their p53-MDM2 binding inhibitory potency and anti-proliferation activities against A549 and PC3 tumor cell lines. Fourteen compounds had appreciably impro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a061c8d877396aedf92b436616af1942
https://pubmed.ncbi.nlm.nih.gov/23601819

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Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives as Hypoxic Selective Anti-tumor Agents

Autor: Qing Xia, Xiaowen Liu, Rong Sheng, Shihao Shangguan, Yongzhou Hu, Yunzhen Hu

Publikováno v: Molecules; Volume 17; Issue 8; Pages: 9683-9696
Molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d756a1b1095c79cd8a2c7ea2d4c67a8

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Akademický článek

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