Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shihan Huo"'
Autor:
Min Ma, Shihan Huo, Ming Zhang, Shuo Qian, Xiaoyu Zhu, Jie Pu, Sailee Rasam, Chao Xue, Shichen Shen, Bo An, Jianmin Wang, Jun Qu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Accurate protein mapping on whole-tissue levels provides critical insights into diseases/therapies. Here, the authors described a novel spatial proteomics method, based on tissue compartmentalization using a 3D-printed micro-scaffold, generated thous
Externí odkaz:
https://doaj.org/article/ce5b1b37fd9b4fc2bc1970c7e8def3b9
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 10, Iss 3, Pp 209-220 (2020)
The past few years have witnessed enormous progresses in the development of antibody-drug conjugates (ADCs). Consequently, comprehensive analysis of ADCs in biological systems is critical in supporting discovery, development and evaluation of these a
Externí odkaz:
https://doaj.org/article/7ba49f167319457bb023079b75db882e
Autor:
Shichen Shen, Xue Wang, Xiaoyu Zhu, Sailee Rasam, Min Ma, Shihan Huo, Shuo Qian, Ming Zhang, Miao Qu, Chenqi Hu, Liang Jin, Yu Tian, Sanjay Sethi, David Poulsen, Jianmin Wang, Chengjian Tu, Jun Qu
Publikováno v:
Nature Protocols. 18:700-731
Robust, reliable quantification of large sample cohorts is often essential for meaningful clinical or pharmaceutical proteomics investigations, but it is technically challenging. When analyzing very large numbers of samples, isotope labeling approach
Autor:
Jie Pu, Chao Xue, Shihan Huo, Qingqing Shen, Yang Qu, Xinxin Yang, Bo An, Thomas E. Angel, Zhuo Chen, John T. Mehl, Huaping Tang, Eric Yang, Timothy W. Sikorski, Jun Qu
Publikováno v:
Analytical chemistry.
Accurate, absolute liquid chromatography-mass spectrometry (LC-MS)-based quantification of target proteins in formalin-fixed paraffin-embedded (FFPE) tissues would greatly expand sample availability for pharmaceutical/clinical investigations but rema
Autor:
Mark Titus, Jun Qu, Jun Li, Xiaoyu Zhu, Miao Qu, Xiaotao Duan, Sailee Rasam, Shichen Shen, Shihan Huo, Min Ma
Publikováno v:
Analytical Chemistry. 93:8711-8718
Quantitative proteomics/metabolomics investigation of laser-capture-microdissection (LCM) cell populations from clinical cohorts affords precise insights into disease/therapeutic mechanisms, nonetheless high-quality quantification remains a prominent
Autor:
Min Ma, Shihan Huo, Ming Zhang, Shuo Qian, Xiaoyu Zhu, Jie Pu, Sailee Rasam, Chao Xue, Shichen Shen, Bo An, Jianmin Wang, Jun Qu
Quantitative protein mapping on whole-tissue levels provides important insights into the spatially-organized regulatory processes/networks related to diseases and therapy, but remains a tremendous challenge. We describe a micro-scaffold assisted spat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd49a276e8568e12cf933b310d1bd15
https://doi.org/10.21203/rs.3.rs-1786070/v1
https://doi.org/10.21203/rs.3.rs-1786070/v1
Publikováno v:
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis, Vol 10, Iss 3, Pp 209-220 (2020)
Journal of Pharmaceutical Analysis, Vol 10, Iss 3, Pp 209-220 (2020)
The past few years have witnessed enormous progresses in the development of antibody-drug conjugates (ADCs). Consequently, comprehensive analysis of ADCs in biological systems is critical in supporting discovery, development and evaluation of these a
Autor:
Joseph P. Balthasar, Lisa J. Benincosa, Luca Ferrari, Michael B. Otteneder, Wolfgang F. Richter, Joseph Ryan Polli, Jie Pu, Shaolian Zhou, Bo An, Faye Vazvaei, Yuan-Ju Chen, Yang Qu, Shihan Huo, Shichen Shen, Jun Qu, Denis Herzog, Roland F Staack, Ming Zhang, Xue Wang
Publikováno v:
Analytical chemistry. 91(5)
Sensitive and high-throughput measurement of biotherapeutics and biomarkers in plasma and tissues is critical for protein-drug development. Enrichment of target signature peptide (SP) after sample digestion permits sensitive LC-MS-based protein quant