Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Shih-Yin Tsai"'
Autor:
Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 198-213 (2023)
Abstract Background Chronic mTORC1 activation in skeletal muscle is linked with age‐associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal
Externí odkaz:
https://doaj.org/article/4d1f09455d51452bad1e1f064452da26
Autor:
Seok-Ting J. Ang, Elisa M. Crombie, Han Dong, Kuan-Ting Tan, Adriel Hernando, Dejie Yu, Stuart Adamson, Seonyoung Kim, Dominic J. Withers, Hua Huang, Shih-Yin Tsai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP
Externí odkaz:
https://doaj.org/article/eda0b3d0d84b4f68a117977871132f65
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.
Externí odkaz:
https://doaj.org/article/5faa98dd54e74eb38a71aec60636557b
Autor:
Han Dong, Shih-Yin Tsai
Publikováno v:
Cells, Vol 12, Iss 17, p 2183 (2023)
Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mi
Externí odkaz:
https://doaj.org/article/a0be7041d67d42bd90cbfb83c89c5ddb
Autor:
Shih-Yin Tsai, Ariana A. Rodriguez, Somasish G. Dastidar, Elizabeth Del Greco, Kaili Lia Carr, Joanna M. Sitzmann, Emmeline C. Academia, Christian Michael Viray, Lizbeth Leon Martinez, Brian Stephen Kaplowitz, Travis D. Ashe, Albert R. La Spada, Brian K. Kennedy
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1903-1914 (2016)
Obesity is a major risk factor driving the global type II diabetes pandemic. However, the molecular factors linking obesity to disease remain to be elucidated. Gender differences are apparent in humans and are also observed in murine models. Here, we
Externí odkaz:
https://doaj.org/article/1cafbdea96754c5997e592ef3c859f9c
Autor:
Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai
Publikováno v:
Crombie, E M, Kim, S, Adamson, S, Dong, H, Lu, T C, Wu, Y, Wu, Y, Levy, Y, Stimple, N, Lam, W M R, Hey, H W D, Withers, D J, Hsu, A L, Bay, B H, Ochala, J & Tsai, S Y 2023, ' Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity ', Journal of Cachexia, Sarcopenia and Muscle, vol. 14, pp. 198–213 . https://doi.org/10.1002/jcsm.13121
Background: Chronic mTORC1 activation in skeletal muscle is linked with age-associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal muscle acc
Autor:
Shih Yin Tsai, Chloe Xiaoyun Chan, Elisa Marie Crombie, Tuan Chun Tan, Simon M. Cool, Wen-Hai Zhuo, Wing Moon Raymond Lam, Hwee Weng Dennis Hey, Way Cherng Chen
Publikováno v:
The Spine Journal. 22:483-494
BACKGROUND Increasing kyphosis of the spine in a human is a well-recognized clinical phenomenon that has been associated with back pain, poor physical performance and disability. The pathophysiology of age-related kyphosis is complex and has been ass
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature communications. 13(1)
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria. Although it is well known that the conjugation of mammal
Publikováno v:
Proteomics. 20(5-6)
Sarcopenia, defined as age-associated decline of muscle mass and function, is a risk factor for mortality and disability, and comorbid with several chronic diseases such as type II diabetes and cardiovascular diseases. Clinical trials showed that nut
Autor:
Lizbeth Leon Martinez, Somasish Ghosh Dastidar, Christian Michael Viray, Albert R. La Spada, Elizabeth Del Greco, Emmeline C. Academia, Travis D. Ashe, Joanna M. Sitzmann, Kaili Lia Carr, Ariana A. Rodriguez, Brian K. Kennedy, Brian Kaplowitz, Shih-Yin Tsai
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1903-1914 (2016)
SummaryObesity is a major risk factor driving the global type II diabetes pandemic. However, the molecular factors linking obesity to disease remain to be elucidated. Gender differences are apparent in humans and are also observed in murine models. H