Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Shih-Shih Chen"'
Autor:
Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Federica Barbaglio, Karen Clise-Dwyer, Vanessa Behrana Jensen, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A. Calin, Michael J. Keating, Maria Teresa Sabrina Bertilaccio
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune ce
Externí odkaz:
https://doaj.org/article/2643535025b44b18b47bc2931c44d1e2
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond, becomes resistant to treatment, relapses during treatment, or transforms into R
Externí odkaz:
https://doaj.org/article/a91848a0c2ce419db38296f329f49a9c
Autor:
Florian Märkl, Christoph Schultheiß, Murtaza Ali, Shih-Shih Chen, Marina Zintchenko, Lukas Egli, Juliane Mietz, Obinna Chijioke, Lisa Paschold, Sebastijan Spajic, Anne Holtermann, Janina Dörr, Sophia Stock, Andreas Zingg, Heinz Läubli, Ignazio Piseddu, David Anz, Marcus Dühren-von Minden, Tianjiao Zhang, Thomas Nerreter, Michael Hudecek, Susana Minguet, Nicholas Chiorazzi, Sebastian Kobold, Mascha Binder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they
Externí odkaz:
https://doaj.org/article/f556d70ecba646069501e54817da7995
Publikováno v:
Frontiers in Immunology; 2024, p01-11, 11p
Autor:
Shih-Shih Chen, Jacqueline C. Barrientos, Gerardo Ferrer, Morgan King-Richards, Yu-Ju Chen, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, Sheila Waters, Jeffery L. Kutok, Marisa Peluso, Sujata Sharma, David T. Weaver, Jonathan A. Pachter, Kanti R. Rai, Nicholas Chiorazzi
Publikováno v:
Clinical Cancer Research. 29:1984-1995
Purpose: Inhibitors of Bruton's tyrosine kinase (BTKi) and PI3K (PI3Ki) have significantly improved therapy of chronic lymphocytic leukemia (CLL). However, the emergence of resistance to BTKi has introduced an unmet therapeutic need. Hence, we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1d04de0e092c271491cfd78719407a
https://doi.org/10.1158/1078-0432.ccr-22-2386
https://doi.org/10.1158/1078-0432.ccr-22-2386
Autor:
Piers E. M. Patten, Gerardo Ferrer, Shih-Shih Chen, Jonathan E. Kolitz, Kanti R. Rai, Steven L. Allen, Jacqueline C. Barrientos, Nikolaos Ioannou, Alan G. Ramsay, Nicholas Chiorazzi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Patient-derived xenograft models of chronic lymphocytic leukemia (CLL) can be created using highly immunodeficient animals, allowing analysis of primary tumor cells in an in vivo setting. However, unlike many other tumors, CLL B lymphocytes do not re
Externí odkaz:
https://doaj.org/article/8a7c17a8f2f34ec0bfe17f199c06f5ca
Autor:
Katrien Van Roosbroeck, Recep Bayraktar, Steliana Calin, Johannes Bloehdorn, Mihnea Paul Dragomir, Keishi Okubo, Maria Teresa Sabrina Bertilaccio, Simonetta Zupo, M. James You, Gianluca Gaidano, Davide Rossi, Shih-Shih Chen, Nicholas Chiorazzi, Philip A. Thompson, Alessandra Ferrajoli, Francesco Bertoni, Stephan Stilgenbauer, Michael J. Keating, George A. Calin
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Richter syndrome is the name given to the transformation of the most frequent type of leukemia, chronic lymphocytic leukemia, into an aggressive lymphoma. Patients with Richter syndrome have limited response to therapies and dismal survival. The unde
Externí odkaz:
https://doaj.org/article/4a33e5992a2c4795ad8573264f7c5381
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Effects of inhibition of PI3K isoforms on CLL-cell proliferation, survival, and migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b915f53399d7fc62583f04718343a06
https://doi.org/10.1158/1078-0432.22820110.v1
https://doi.org/10.1158/1078-0432.22820110.v1
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Purpose:Inhibitors of Bruton's tyrosine kinase (BTKi) and PI3K (PI3Ki) have significantly improved therapy of chronic lymphocytic leukemia (CLL). However, the emergence of resistance to BTKi has introduced an unmet therapeutic need. Hence, we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3d6e09a3e1db0191cbb96707dd981d
https://doi.org/10.1158/1078-0432.c.6605170
https://doi.org/10.1158/1078-0432.c.6605170
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
IC50 values of PI3K isoform inhibitors used. Duvelisib5, IPI-3063 (PI3K-d inhibitor)5, IPI-549 (PI3K-g inhibitor used in vitro)50, IPI-5243 (PI3K-g inhibitor used in vivo).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ead5388474787e49d884681dd3bc434
https://doi.org/10.1158/1078-0432.22652506
https://doi.org/10.1158/1078-0432.22652506