Výsledky vyhledávání - "Shih-Ming Liao"

Akademický článek

Suppression of Angiogenesis by Targeting Cyclin-Dependent Kinase 7 in Human Umbilical Vein Endothelial Cells and Renal Cell Carcinoma: An In Vitro and In Vivo Study

Autor: Chung-Sheng Shi, Kuan-Lin Kuo, Mei-Sin Chen, Po-Ming Chow, Shing-Hwa Liu, Yu-Wei Chang, Wei-Chou Lin, Shih-Ming Liao, Chen-Hsun Hsu, Fu-Shun Hsu, Hong-Chiang Chang, Kuo-How Huang

Publikováno v: Cells, Vol 8, Iss 11, p 1469 (2019)

Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor o

Externí odkaz: https://doaj.org/article/e0c99c520cff4897ac1562897a6dc8b1

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Akademický článek

The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study

Autor: Kuan-Lin Kuo, Shing-Hwa Liu, Wei-Chou Lin, Po-Ming Chow, Yu-Wei Chang, Shao-Ping Yang, Chung-Sheng Shi, Chen-Hsun Hsu, Shih-Ming Liao, Hong-Chiang Chang, Kuo-How Huang

Publikováno v: Cells, Vol 8, Iss 10, p 1268 (2019)

After chemotherapy for the treatment of metastatic bladder urothelial carcinoma (UC), most patients inevitably encounter drug resistance and resultant treatment failure. Deubiquitinating enzymes (DUBs) remove ubiquitin from target proteins and play a

Externí odkaz: https://doaj.org/article/00df1087058e4cbfabb570695dfe21e3

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Dissertation/ Thesis

Why are Green Buildings not Green?A Study of the discrepancies between expectation and practice of Green Buildings in Taiwan

Autor: Shih-Ming Liao, 廖士銘

97
The concept of “Green Building”, to the understanding of the public in Taiwan, is still obscure and distant from their lives even though it has been pervasive in countries abroad. To be more specific, the general public might have vague a

Externí odkaz: http://ndltd.ncl.edu.tw/handle/29198912457238524583

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Dissertation/ Thesis

The Study of Financial and Risk Assessment by Developing the Private Participation in Public Infrastructure -The Case Study of Taipei Neihu Metro Stations

Autor: Shih-ming Liao, 廖世名

97
The MRT system is a major public building of the Government Development in Taiwan, significant effect on the daily lives of the public. Public building itself has a large amount of investment has slowed but the nature of recovery. Therefore t

Externí odkaz: http://ndltd.ncl.edu.tw/handle/26856030846713158405

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Abstract 6128: Deubiquitinating enzyme Inhibitor PR-619 inducesendoplasmic reticulum stress-related apoptosisin human chondrosarcoma

Autor: Kuan-Lin Kuo, Chen-Hsun Hsu, Shih-Ming Liao, Kuo-Yuan Huang

Publikováno v: Cancer Research. 83:6128-6128

It is reported that PR-619 is a deubiquitination enzyme inhibitor that can exert anti-tumor effects on a variety of malignancies. We conducted this study to explore the antitumor effects of PR-619 on chondrosarcoma in vitro and in vivo by using two d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9d3af0f97babd07df7a1140c7dbc8ac
https://doi.org/10.1158/1538-7445.am2023-6128

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PR-619, a General Inhibitor of Deubiquitylating Enzymes, Diminishes Cisplatin Resistance in Urothelial Carcinoma Cells through the Suppression of c-Myc: An In Vitro and In Vivo Study

Autor: Shing-Hwa Liu, Chen-Hsun Hsu, Yen-Ling Chiu, Jun-Ren Dong, Fu-Shun Hsu, Wei-Chou Lin, Shao-Ping Yang, Kuo-How Huang, Shih-Chen Chang, Ruei-Je Chang, Yueh-Tang Chen, Kuan-Lin Kuo, Shih-Ming Liao

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11706, p 11706 (2021)

Cisplatin-based chemotherapy is the standard treatment for bladder urothelial carcinoma (UC). Most patients experience chemoresistance, the primary cause of treatment failure, which leads to disease relapse. The underlying mechanism of chemoresistanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1342a9d7a19b70616e2a674e409757e9

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THZ1, a covalent CDK7 inhibitor, enhances gemcitabine-induced cytotoxicity via suppression of Bcl-2 in urothelial carcinoma

Autor: Kuan-Lin, Kuo, Wei-Chou, Lin, Shing-Hwa, Liu, Fu-Shun, Hsu, Yu, Kuo, Shih-Ming, Liao, Shao-Ping, Yang, Zuo-He, Wang, Chen-Hsun, Hsu, Kuo-How, Huang

Publikováno v: Am J Cancer Res

Chemotherapy with gemcitabine plus cisplatin remains the mainstay of treatment for metastatic urothelial carcinoma (UC); however, drug resistance occurs in most patients and eventually leads to treatment failure. In this study, we investigated the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9dcc9ff7038a1222b86407380ba8357d
https://pubmed.ncbi.nlm.nih.gov/33520367

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Neddylation inhibitor, MLN4924 suppresses angiogenesis in huvecs and solid cancers

Autor: Chung-Sheng, Shi, Kuan-Lin, Kuo, Wei-Chou, Lin, Mei-Sin, Chen, Shing-Hwa, Liu, Shih-Ming, Liao, Chen-Hsun, Hsu, Yu-Wei, Chang, Hong-Chiang, Chang, Kuo-How, Huang

Publikováno v: American journal of cancer research. 10(3)

Cullin-RING E3 ligases are involved in the ubiquitination of substrates that regulate important biological processes and are a potential therapeutic target in many types of cancer. MLN4924, a small molecule of NEDD8-activating enzyme inhibitor, inact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4526e29aa2d204294fad7a8a921d6c66
https://pubmed.ncbi.nlm.nih.gov/32266102

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