Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shih-Chang Hsueh"'
Autor:
Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-21 (2023)
Abstract Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved dr
Externí odkaz:
https://doaj.org/article/7c5613a4803945af9101f28f707d2991
Autor:
Elliot J. Glotfelty, Luis B. Tovar-y-Romo, Shih-Chang Hsueh, David Tweedie, Yazhou Li, Brandon K. Harvey, Barry J. Hoffer, Tobias E. Karlsson, Lars Olson, Nigel H. Greig
Publikováno v:
Cells, Vol 12, Iss 10, p 1367 (2023)
Neuroinflammation is a unifying factor among all acute central nervous system (CNS) injuries and chronic neurodegenerative disorders. Here, we used immortalized microglial (IMG) cells and primary microglia (PMg) to understand the roles of the GTPase
Externí odkaz:
https://doaj.org/article/92ddbaddb19c409ea44ce0d43af5de5a
Autor:
Katherine O. Kopp, Margaret E. Greer, Elliot J. Glotfelty, Shih-Chang Hsueh, David Tweedie, Dong Seok Kim, Marcella Reale, Neil Vargesson, Nigel H. Greig
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 747 (2023)
The immunomodulatory imide drug (IMiD) class, which includes the founding drug member thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically improved the clinical treatment of specific cancers, such as multiple myelom
Externí odkaz:
https://doaj.org/article/b75a2ab503f046888e680425f60b8ccd
Autor:
Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen, John Chung-Che Wu, Jia-Yi Wang, Yi-Syue Tsou, Inho Hwang, Yukyung Kim, Dayeon Gil, Eui Jung Jo, Baek-Soo Han, David Tweedie, Daniela Lecca, Michael T. Scerba, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig, Yung-Hsiao Chiang
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 950 (2022)
(1) Background: An important concomitant of stroke is neuroinflammation. Pomalidomide, a clinically available immunomodulatory imide drug (IMiD) used in cancer therapy, lowers TNF-α generation and thus has potent anti-inflammatory actions. Well-tole
Externí odkaz:
https://doaj.org/article/abe37d4afed640b4839048006b4ded35
Autor:
Shih-Chang Hsueh, Daniela Lecca, Nigel H. Greig, Jia-Yi Wang, Warren Selman, Barry J. Hoffer, Jonathan P. Miller, Yung-Hsiao Chiang
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited treatment options. We have previously shown that (-)-phenserine (Phen), an acetylcholinesterase inhibitor originally designed an
Externí odkaz:
https://doaj.org/article/b2324a6a70c7428890dc11f2aabd8f1d
Autor:
Yu-Wen Yu, Shih-Chang Hsueh, Jing-Huei Lai, Yen-Hua Chen, Shuo-Jhen Kang, Kai-Yun Chen, Tsung-Hsun Hsieh, Barry J. Hoffer, Yazhou Li, Nigel H. Greig, Yung-Hsiao Chiang
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1153 (2018)
In the present study, the effectiveness of glucose-dependent insulinotropic polypeptide (GIP) was evaluated by behavioral tests in 6-hydroxydopamine (6-OHDA) hemi-parkinsonian (PD) rats. Pharmacokinetic measurements of GIP were carried out at the sam
Externí odkaz:
https://doaj.org/article/e2b4eabd69e8428aa090ecbec69b0a17
Autor:
Shih-Chang Hsueh, Kai-Yun Chen, Jing-Huei Lai, Chung-Che Wu, Yu-Wen Yu, Yu Luo, Tsung-Hsun Hsieh, Yung-Hsiao Chiang
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 2, p 508 (2018)
Background: Parkinson’s disease (PD) is typically characterized by impairment of motor function. Gait disturbances similar to those observed in patients with PD can be observed in animals after injection of neurotoxin 6-hydroxydopamine (6-OHDA) to
Externí odkaz:
https://doaj.org/article/29f85f2aba8a4d11a56e90a858fd80a0
Autor:
Daniela Lecca, Yoo Jin Jung, Michael T. Scerba, Inho Hwang, Yu Kyung Kim, Sun Kim, Sydney Modrow, David Tweedie, Shih‐Chang Hsueh, Dong Liu, Weiming Luo, Elliot Glotfelty, Yazhou Li, Jia‐Yi Wang, Yu Luo, Barry J. Hoffer, Dong Seok Kim, Ross A. McDevitt, Nigel H. Greig
Publikováno v:
Alzheimer's & Dementia. 18:2327-2340
Evaluating the efficacy of 3,6'-dithioPomalidomide in 5xFAD Alzheimer's disease (AD) mice to test the hypothesis that neuroinflammation is directly involved in the development of synaptic/neuronal loss and cognitive decline.Amyloid-β (Aβ) or tau-fo
Autor:
Daniela Lecca, Yoo Jin Yung, Michael T Scerba, David Tweedie, Shih Chang Hsueh, Barry Hoffer, Dong Seok Kim, Ross A McDevitt, Nigel H Greig
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Shih Chang Hsueh, Michael T. Scerba, David Tweedie, Daniela Lecca, Dong Seok Kim, Abdul Mannan Baig, Yu Kyung Kim, Inho Hwang, Sun Kim, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig
Publikováno v:
Biomedicines; Volume 10; Issue 10; Pages: 2449
Traumatic brain injury (TBI) is a major risk factor for several neurodegenerative disorders, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Neuroinflammation is a cause of later secondary cell death following TBI, has the potent