Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shih-Chang Hsueh"'
Autor:
Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-21 (2023)
Abstract Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved dr
Externí odkaz:
https://doaj.org/article/7c5613a4803945af9101f28f707d2991
Autor:
Elliot J. Glotfelty, Luis B. Tovar-y-Romo, Shih-Chang Hsueh, David Tweedie, Yazhou Li, Brandon K. Harvey, Barry J. Hoffer, Tobias E. Karlsson, Lars Olson, Nigel H. Greig
Publikováno v:
Cells, Vol 12, Iss 10, p 1367 (2023)
Neuroinflammation is a unifying factor among all acute central nervous system (CNS) injuries and chronic neurodegenerative disorders. Here, we used immortalized microglial (IMG) cells and primary microglia (PMg) to understand the roles of the GTPase
Externí odkaz:
https://doaj.org/article/92ddbaddb19c409ea44ce0d43af5de5a
Autor:
Katherine O. Kopp, Margaret E. Greer, Elliot J. Glotfelty, Shih-Chang Hsueh, David Tweedie, Dong Seok Kim, Marcella Reale, Neil Vargesson, Nigel H. Greig
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 747 (2023)
The immunomodulatory imide drug (IMiD) class, which includes the founding drug member thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically improved the clinical treatment of specific cancers, such as multiple myelom
Externí odkaz:
https://doaj.org/article/b75a2ab503f046888e680425f60b8ccd
Autor:
Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen, John Chung-Che Wu, Jia-Yi Wang, Yi-Syue Tsou, Inho Hwang, Yukyung Kim, Dayeon Gil, Eui Jung Jo, Baek-Soo Han, David Tweedie, Daniela Lecca, Michael T. Scerba, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig, Yung-Hsiao Chiang
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 950 (2022)
(1) Background: An important concomitant of stroke is neuroinflammation. Pomalidomide, a clinically available immunomodulatory imide drug (IMiD) used in cancer therapy, lowers TNF-α generation and thus has potent anti-inflammatory actions. Well-tole
Externí odkaz:
https://doaj.org/article/abe37d4afed640b4839048006b4ded35
Autor:
Shih-Chang Hsueh, Daniela Lecca, Nigel H. Greig, Jia-Yi Wang, Warren Selman, Barry J. Hoffer, Jonathan P. Miller, Yung-Hsiao Chiang
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited treatment options. We have previously shown that (-)-phenserine (Phen), an acetylcholinesterase inhibitor originally designed an
Externí odkaz:
https://doaj.org/article/b2324a6a70c7428890dc11f2aabd8f1d
Autor:
Daniela Lecca, Yoo Jin Jung, Michael T. Scerba, Inho Hwang, Yu Kyung Kim, Sun Kim, Sydney Modrow, David Tweedie, Shih‐Chang Hsueh, Dong Liu, Weiming Luo, Elliot Glotfelty, Yazhou Li, Jia‐Yi Wang, Yu Luo, Barry J. Hoffer, Dong Seok Kim, Ross A. McDevitt, Nigel H. Greig
Publikováno v:
Alzheimer's & Dementia. 18:2327-2340
Evaluating the efficacy of 3,6'-dithioPomalidomide in 5xFAD Alzheimer's disease (AD) mice to test the hypothesis that neuroinflammation is directly involved in the development of synaptic/neuronal loss and cognitive decline.Amyloid-β (Aβ) or tau-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2fe36db36b97f86816ed5b7768a57a
https://doi.org/10.1002/alz.12610
https://doi.org/10.1002/alz.12610
Autor:
Daniela Lecca, Yoo Jin Yung, Michael T Scerba, David Tweedie, Shih Chang Hsueh, Barry Hoffer, Dong Seok Kim, Ross A McDevitt, Nigel H Greig
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbc9eb44ca4cdbd810fce06d507130c
https://doi.org/10.1002/alz.061558
https://doi.org/10.1002/alz.061558
Autor:
Shih Chang Hsueh, Michael T. Scerba, David Tweedie, Daniela Lecca, Dong Seok Kim, Abdul Mannan Baig, Yu Kyung Kim, Inho Hwang, Sun Kim, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig
Publikováno v:
Biomedicines; Volume 10; Issue 10; Pages: 2449
Traumatic brain injury (TBI) is a major risk factor for several neurodegenerative disorders, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Neuroinflammation is a cause of later secondary cell death following TBI, has the potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cd0af9574a7439f1f04316e8436ea2
Autor:
Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, Elliot J. Glotfelty, David Tweedie, Nigel H. Greig, Yung Hsiao Chiang, Shih Chang Hsueh, Robert E. Becker, Barry J. Hoffer, Daniela Lecca
Publikováno v:
CNS Neuroscience & Therapeutics
Aim Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults and the elderly, and is a key contributing factor in about 30% of all injury‐associated deaths occurring within the United States of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ab176d194c952b503dbfdf7e51469d
https://doi.org/10.1111/cns.13274
https://doi.org/10.1111/cns.13274
Autor:
Jonathan P. Miller, Nigel H. Greig, Daniela Lecca, Shih Chang Hsueh, Yung Hsiao Chiang, Warren R. Selman, Barry J. Hoffer, Jia Yi Wang
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Cell Transplantation
Cell Transplantation
Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited treatment options. We have previously shown that (-)-phenserine (Phen), an acetylcholinesterase inhibitor originally designed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ebeb1a7f1855774b622618bcfc57ca
https://doi.org/10.1177/0963689719854693
https://doi.org/10.1177/0963689719854693