Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Shih Hsing Leir"'
Autor:
Shih-Hsing Leir, Svyatoslav Tkachenko, Alekh Paranjapye, Frederick Meckler, Arnaud J. Van Wettere, Jenny L. Kerschner, Elizabeth Kuznetsov, Makayla Schacht, Pulak Gillurkar, Misha Regouski, Iuri Viotti Perisse, Cheyenne M. Marriott, Ying Liu, Ian Bunderson, Kenneth L. White, Irina A. Polejaeva, Ann Harris
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-29 (2024)
Abstract Background Pancreatic fibrosis is an early diagnostic feature of the common inherited disorder cystic fibrosis (CF). Many people with CF (pwCF) are pancreatic insufficient from birth and the replacement of acinar tissue with cystic lesions a
Externí odkaz:
https://doaj.org/article/3d9ef7d36912408cb3c56c41ca33552c
Autor:
Arnaud J. Van Wettere, Shih‐Hsing Leir, Calvin U. Cotton, Misha Regouski, Iuri Viotti Perisse, Jenny L. Kerschner, Alekh Paranjapye, Zhiqiang Fan, Ying Liu, Makayla Schacht, Kenneth L. White, Irina A. Polejaeva, Ann Harris
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 1, Pp 13-26 (2023)
Abstract Highly effective modulator therapies for cystic fibrosis (CF) make it a treatable condition for many people. However, although CF respiratory illness occurs after birth, other organ systems particularly in the digestive tract are damaged bef
Externí odkaz:
https://doaj.org/article/43c1be17a98f465c84755dd90b13f12b
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102967- (2022)
Cross-talk between lung epithelial cells and their microenvironment has an important physiological role in development. Using an in vitro model of differentiation of human induced pluripotent stem cells (iPSCs) to air–liquid interface (ALI)-culture
Externí odkaz:
https://doaj.org/article/ed3841b705c9409eb9a9ea98179484c6
Autor:
Iuri Viotti Perisse, Zhiqiang Fan, Arnaud Van Wettere, Ying Liu, Shih‐Hsing Leir, Jacob Keim, Misha Regouski, Michael D. Wilson, Kelly M. Cholewa, Sara N. Mansbach, Thomas J. Kelley, Zhongde Wang, Ann Harris, Kenneth L. White, Irina A. Polejaeva
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 10, Pp 841-854 (2021)
Abstract Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The F508del and G542X are the most common mutations found in US patients, accounting for 86.4% and 4.6% of all mutations
Externí odkaz:
https://doaj.org/article/795c1ef4464940329970193fbfae4126
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 3, Pp 151231- (2022)
The evolutionary relationship of cells within tissues having a similar function but located in different anatomical sites is of considerable biological interest. The development of single-cell RNA sequencing (scRNA-seq) protocols has greatly enhanced
Externí odkaz:
https://doaj.org/article/a31e211b13a24795b9063efe7a9fb326
Publikováno v:
Asian Journal of Andrology, Vol 20, Iss 6, Pp 539-544 (2018)
The epithelium of the human epididymis maintains an appropriate luminal environment for sperm maturation that is essential for male fertility. Regional expression of small noncoding RNAs such as microRNAs contributes to segment-specific gene expressi
Externí odkaz:
https://doaj.org/article/9cb64ed151e647a6b7c3005528be98ca
Autor:
Arnaud J. Van Wettere, Shih‐Hsing Leir, Calvin U. Cotton, Misha Regouski, Iuri Viotti Perisse, Jenny L. Kerschner, Alekh Paranjapye, Zhiqiang Fan, Ying Liu, Makayla Schacht, Kenneth L. White, Irina A. Polejaeva, Ann Harris
Publikováno v:
FASEB BioAdvances. 5:13-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f58c70a325e8eeceb7980d1748ac6d9
https://doi.org/10.1096/fba.2022-00085
https://doi.org/10.1096/fba.2022-00085
Autor:
Shiyi Yin, Alekh Paranjapye, Monali NandyMazumdar, Shih Hsing Leir, James A. Browne, Ann Harris
Publikováno v:
Biochemical Journal
The cystic fibrosis transmembrane conductance regulator (CFTR) gene lies within a topologically associated domain (TAD) in which multiple cis-regulatory elements (CREs) and transcription factors (TFs) regulate its cell-specific expression. The CREs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fdb469750538054a451c59b02c9768
https://doi.org/10.1042/bcj20210252
https://doi.org/10.1042/bcj20210252
Autor:
Shih Hsing Leir, Monali NandyMazumdar, Alekh Paranjapye, Shiyi Yin, Jenny L. Kerschner, Ann Harris
Publikováno v:
Developmental Dynamics. 250:684-700
Background Cell-specific and developmental mechanisms contribute to expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, however, its developmental regulation is poorly understood. Here we use human induced pluripotent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee50cbddfa62bb778a4fe4f646c28124
https://doi.org/10.1002/dvdy.293
https://doi.org/10.1002/dvdy.293
Autor:
Dannielle L. Skander, Ann Harris, Shiyi Yin, Gurkan Bebek, Shih Hsing Leir, Jenny L. Kerschner, Alekh Paranjapye
Publikováno v:
Journal of Cellular and Molecular Medicine
The availability of robust protocols to differentiate induced pluripotent stem cells (iPSCs) into many human cell lineages has transformed research into the origins of human disease. The efficacy of differentiating iPSCs into specific cellular models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6401a79f9b09326bcaf495243bbf99
https://doi.org/10.1111/jcmm.15568
https://doi.org/10.1111/jcmm.15568