Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shih Chu Kao"'
Autor:
Vanessa Strings-Ufombah, Alberto Malerba, Shih-Chu Kao, Sonal Harbaran, Fanny Roth, Ornella Cappellari, Ngoc Lu-Nguyen, Keiko Takahashi, Sophie Mukadam, Georgina Kilfoil, Claudia Kloth, Petrus Roelvink, George Dickson, Capucine Trollet, David Suhy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 67-78 (2021)
Oculopharyngeal muscular dystrophy (OPMD) is a rare autosomal dominant disease that results from an alanine expansion in the N-terminal domain of Poly-A Binding Protein Nuclear-1 (PABPN1). We have recently demonstrated that a two-vector gene therapy
Externí odkaz:
https://doaj.org/article/a38e66f16de34830a7d74e6ea8d9e973
Autor:
Chih‐Han Wu, Jui‐Ti Nien, Chi‐Yen Lin, Ruei‐Hong Li, Chien‐Heng Chu, Shih‐Chu Kao, Yu‐Kai Chang
Publikováno v:
Psychophysiology. 59
Although beneficial associations between cardiorespiratory fitness and cognitive function have been established, whether cardiorespiratory fitness is related to behavioral and neuroelectric indices of performance during a prolonged inhibitory control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e697a04ad773d586810a6c33677cbfdb
https://doi.org/10.1111/psyp.14086
https://doi.org/10.1111/psyp.14086
Autor:
Andrew McGeehan, Joselyn R. Del Rosario, Young K. Chen, Lihong Shi, James M. Veal, Michael S. Weiss, David J. Hosfield, Alessandro Cuomo, Neethan A. Lobo, Jennifer Matuszkiewicz, Shih Chu Kao, Jeffrey A. Stafford, Tiziana Bonaldi, Michael Brennan Wallace, Natalie Y. Yuen, Ryan Stansfield, Shawn M. O'Connell, Chon Lai, Toufike Kanouni
Publikováno v:
ACS medicinal chemistry letters. 8(8)
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fac222f0833b41a42e89ee96531a18
https://pubmed.ncbi.nlm.nih.gov/28835804
https://pubmed.ncbi.nlm.nih.gov/28835804
Autor:
Romuald Corbau, Olga Zelenaia, Katherine A. High, Sterghios Moschos, Helen Lavender, J. Fraser Wright, David Suhy, Bernd Hauck, Kyle Hayes, Shih-Chu Kao, Laurence O. Whiteley, Tin Mao, B E Souberbielle, Curt Scribner, Andrew D. Burdick, Hubert Denise, Sara H Renison, Alexander A. Kolykhalov, Shangzhen Zhou, Kevin Brady, Peter W. Roelvink
Publikováno v:
Molecular Therapy. 20(9):1737-1749
The hepatitis C virus (HCV) chronically infects 2% of the world population and effective treatment is limited by long duration and significant side-effects. Here, we describe a novel drug, intended as a “single-shot ” therapy, which expresses thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cf4df837f30b03fa37cdee33a8aa35
Publikováno v:
Journal of Biological Chemistry. 279:1942-1949
Extracellular deposition of amyloid-beta (Abeta) aggregates in the brain represents one of the histopathological hallmarks of Alzheimer's disease (AD). Abeta peptides are generated from proteolysis of the amyloid precursor proteins (APPs) by beta- an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c37cde3670fa5c57f704740cbb8d08
https://doi.org/10.1074/jbc.m309219200
https://doi.org/10.1074/jbc.m309219200
Publikováno v:
Molecular Therapy. 24:S58-S59
Background: TT-034 is a DNA-directed RNA interference (ddRNAi) agent designed for the treatment of chronic HCV infection and is currently being tested in a phase I/IIa clinical study. TT-034 is comprised of a vector that expresses three independent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3ce9c949ab02f958645d2045c4a1265
https://doi.org/10.1016/s1525-0016(16)32954-9
https://doi.org/10.1016/s1525-0016(16)32954-9
Autor:
Ming-Sum Lee, Shih Chu Kao, Weiming Xia, Rachael L. Neve, Ying Zhou, Huang Chun Tseng, Li-Huei Tsai, Cynthia A. Lemere, Michael K. Ahlijanian
Publikováno v:
The Journal of Cell Biology
Amyloid-beta peptide (Abeta) aggregate in senile plaque is a key characteristic of Alzheimer's disease (AD). Here, we show that phosphorylation of amyloid precursor protein (APP) on threonine 668 (P-APP) may play a role in APP metabolism. In AD brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f840eb9d40d5bf7c037c4a322c43e9ba
https://doi.org/10.1083/jcb.200301115
https://doi.org/10.1083/jcb.200301115
Publikováno v:
Journal of Biological Chemistry. 276:18169-18177
In PC12 cells, epidermal growth factor (EGF) transiently stimulates the mitogen-activated protein (MAP) kinases, ERK1 and ERK2, and provokes cellular proliferation. In contrast, nerve growth factor (NGF) stimulation leads to the sustained activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5560e41e442c35c27426da15b6cc6a2c
https://doi.org/10.1074/jbc.m008870200
https://doi.org/10.1074/jbc.m008870200
Publikováno v:
Journal of Cellular Biochemistry. 71:82-95
A rat polyclonal anti-M-line protein antiserum and three mouse monoclonal anti-titin antibodies (E2, F3, and A12) were used to study the spatiotemporal relationship between M-line proteins and titin during myofibril assembly in cultured chicken cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97314b4affd1183bb0a152a61523a35f
https://doi.org/10.1002/(sici)1097-4644(19981001)71:1<82::aid-jcb9>3.0.co
https://doi.org/10.1002/(sici)1097-4644(19981001)71:1<82::aid-jcb9>3.0.co
Publikováno v:
Molecular Therapy. 24:S58
Background: The hepatitis C virus (HCV) is an attractive target for RNA interference (RNAi) based therapeutics because its genome consists of a single, positive stranded RNA and its replication occurs strictly within the cytoplasm. TT-034 is a DNA-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49677b86ffe645d9f9da1f2222e69065
https://doi.org/10.1016/s1525-0016(16)32952-5
https://doi.org/10.1016/s1525-0016(16)32952-5