Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shigeyuki Mukudai"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Similar to the hypertrophic scar and keloids, the efficacy of glucorticoids (GC) for vocal fold injury is highly variable. We previously reported dexamethasone enhanced the pro-fibrotic effects of transforming growth factor (TGF)-β as a pot
Externí odkaz:
https://doaj.org/article/c74949bf7687426e93e1fbbc5bb29eb1
Autor:
Shigeyuki Mukudai, Iv Kraja, Renjie Bing, Danielle M. Nalband, Mallika Tatikola, Nao Hiwatashi, Kent Kirshenbaum, Ryan C. Branski
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 4, Iss 6, Pp 640-644 (2019)
Objective We hypothesize that Smad3 is a master regulator of fibrosis in the vocal folds (VFs) and RNA‐based therapeutics targeting Smad3 hold therapeutic promise. Delivery remains challenging. We previously described a novel synthetic peptoid olig
Externí odkaz:
https://doaj.org/article/7280171b64174aa897cec2c7d7ca60df
Publikováno v:
Koutou (THE LARYNX JAPAN). 34:144-150
Autor:
Takahiro Tsujikawa, Alisa Kimura, Hiroki Morimoto, Sumiyo Saburi, Junichi Mitsuda, Kanako Yoshimura, Daichi Mori, Gaku Ohmura, Shigeyuki Mukudai, Yoichiro Sugiyama, Shigeru Hirano
Publikováno v:
JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY. 32:117-120
Publikováno v:
Journal of Voice.
Autor:
Machiko Ogawa, Shigeyuki Mukudai, Yoichiro Sugiyama, Hiroki Matsushita, Shota Kinoshita, Satomi Ozawa, Keiko Hashimoto, Shinya Fuse, Mami Kaneko, Yosuke Nakanishi, Tomokazu Yoshizaki, Chie Sotozono, Shigeru Hirano
Publikováno v:
The Laryngoscope. 132:2017-2025
Vocal fold (VF) scar and sulcus cause severe vocal problems, but optimal methods have not been established. Total replacement of the mucosa is required particularly for cases in which the whole lamina propria is occupied by severe fibrosis and vibrat
Autor:
Hiroki Matsushita, Shigeyuki Mukudai, Satomi Ozawa, Shota Kinoshita, Keiko Hashimoto, Mami Kaneko, Yoichiro Sugiyama, Ryan C. Branski, Shigeru Hirano
Publikováno v:
The Laryngoscope.
Effective treatments for vocal fold fibrosis remain elusive. Tamoxifen (TAM) is a selective estrogen receptor modulator and was recently reported to have antifibrotic actions. We hypothesized that TAM inhibits vocal fold fibrosis via altered transfor
Autor:
Akiyo Takemura, Yoichiro Sugiyama, Ryota Yamamoto, Shota Kinoshita, Mami Kaneko, Shinya Fuse, Keiko Hashimoto, Shigeyuki Mukudai, Toshiro Umezaki, Mathias Dutschmann, Shigeru Hirano
Publikováno v:
Brain research. 1797
To examine the role of neurons of the pontine respiratory group (PRG) overlapping with the Kölliker-Fuse nucleus in the regulation of swallowing, we compared the activity of swallowing motor activities and interneuron discharge in the dorsal swallow
Autor:
Hiroki Morimoto, Takahiro Tsujikawa, Aya Miyagawa-Hayashino, Alisa Kimura, Sumiyo Saburi, Junichi Mitsuda, Kanako Yoshimura, Gaku Ohmura, Shigeyuki Mukudai, Hikaru Nagao, Yoichiro Sugiyama, Shibata Saya, Hiroshi Ogi, Eiichi Konishi, Kyoko Itoh, Shigeru Hirano
Publikováno v:
Cancer Research. 83:4453-4453
Neutrophil-to-lymphocyte ratio (NLR) in peripheral blood is an emerging biomarker candidate of immunotherapy in a wide range of cancers. However, little is known about the potential relationships between the tumor immune microenvironment and systemic
Publikováno v:
The Laryngoscope. 131:2285-2291
OBJECTIVES/HYPOTHESIS Vocal fold fibrosis remains a significant clinical challenge. Estrogens, steroid hormones predominantly responsible for secondary sexual characteristics in women, have been shown to alter wound healing and limit fibrosis, but th