Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Shigeyuki Matsumoto"'
Autor:
Mai Suzuki, Ken Uchibori, Tomoko Oh-hara, Yumi Nomura, Ryusei Suzuki, Ai Takemoto, Mitsugu Araki, Shigeyuki Matsumoto, Yukari Sagae, Mutsuko Kukimoto-Niino, Yusuke Kawase, Mikako Shirouzu, Yasushi Okuno, Makoto Nishio, Naoya Fujita, Ryohei Katayama
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract Brigatinib-based therapy was effective against osimertinib-resistant EGFR C797S mutants and is undergoing clinical studies. However, tumor relapse suggests additional resistance mutations might emerge. Here, we first demonstrated the binding
Externí odkaz:
https://doaj.org/article/b24524fa05214c18b25d982517bfb2eb
Publikováno v:
Biophysics and Physicobiology, Vol 20 (2023)
Protein functions associated with biological activity are precisely regulated by both tertiary structure and dynamic behavior. Thus, elucidating the high-resolution structures and quantitative information on in-solution dynamics is essential for unde
Externí odkaz:
https://doaj.org/article/49845ee0524a4ff5b5b3dc1916d96664
Autor:
Ikuko Miyaguchi, Miwa Sato, Akiko Kashima, Hiroyuki Nakagawa, Yuichi Kokabu, Biao Ma, Shigeyuki Matsumoto, Atsushi Tokuhisa, Masateru Ohta, Mitsunori Ikeguchi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Low-resolution electron density maps can pose a major obstacle in the determination and use of protein structures. Herein, we describe a novel method, called quality assessment based on an electron density map (QAEmap), which evaluates local
Externí odkaz:
https://doaj.org/article/1fa8c0ee19154d2ebf828473bf0e9fe0
Autor:
Mitsugu Araki, Shigeyuki Matsumoto, Gert-Jan Bekker, Yuta Isaka, Yukari Sagae, Narutoshi Kamiya, Yasushi Okuno
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Molecular dynamics (MD) techniques enable atomic-level observations, but simulations of “slow” biomolecular processes are challenging because of current computer speed limitations. Here, the authors develop a method to accelerate MD simulations b
Externí odkaz:
https://doaj.org/article/948c894a587d4e55a4cd9da8f1b04294
Autor:
Takahiro Yoshizawa, Ken Uchibori, Mitsugu Araki, Shigeyuki Matsumoto, Biao Ma, Ryo Kanada, Yosuke Seto, Tomoko Oh-hara, Sumie Koike, Ryo Ariyasu, Satoru Kitazono, Hironori Ninomiya, Kengo Takeuchi, Noriko Yanagitani, Satoshi Takagi, Kazuma Kishi, Naoya Fujita, Yasushi Okuno, Makoto Nishio, Ryohei Katayama
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract Approximately 15–30% of patients with lung cancer harbor mutations in the EGFR gene. Major EGFR mutations (>90% of EGFR-mutated lung cancer) are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs). Many uncommon EGFR mutations have
Externí odkaz:
https://doaj.org/article/c1c4f342481c4dad8da1ff3a202ae813
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Supplementary Table from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4dbf0838ee6bcb973084d0999cd8a
https://doi.org/10.1158/0008-5472.22431953.v1
https://doi.org/10.1158/0008-5472.22431953.v1
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Supplementary Data from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2332f3d7e4ca835c48eb6ee536660cc6
https://doi.org/10.1158/0008-5472.22431980
https://doi.org/10.1158/0008-5472.22431980
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Distinguishing oncogenic mutations from variants of unknown significance (VUS) is critical for precision cancer medicine. Here, computational modeling of 71,756 RET variants for positive selection together with functional assays of 110 representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73b3214a9408945f8b51085a44eb5b7
https://doi.org/10.1158/0008-5472.c.6514040.v1
https://doi.org/10.1158/0008-5472.c.6514040.v1
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Supplementary Figure from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260e34aeed80d1f60a6705138596d6e4
https://doi.org/10.1158/0008-5472.22431968.v1
https://doi.org/10.1158/0008-5472.22431968.v1
Identifying compound-protein interactions (CPIs) is crucial for drug discovery. Because experimentally validating CPIs is often time-consuming and costly, computational approaches are expected to facilitate the process. Rapid growths of available CPI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24f98cf489909678509f04cb73baf3b8
https://doi.org/10.26434/chemrxiv-2023-jsrq5
https://doi.org/10.26434/chemrxiv-2023-jsrq5