Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Shigeyasu Ichihara"'
Autor:
Toshikazu Yamazaki, Chikako Murasaki, Isao Umeda, Nobuo Shimma, Jun Ohwada, Shigeyasu Ichihara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2775-2780
Water soluble N-benzyltriazolium or N-benzylimidazolium salt type prodrugs of several highly lipophilic triazole or imidazole antifungals have been synthesized. They were designed to undergo an enzymatic activation followed by a self-cleavage to rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e8420a84ab55eaa9b96e496075212a
https://doi.org/10.1016/s0960-894x(02)00557-7
https://doi.org/10.1016/s0960-894x(02)00557-7
Autor:
Kiyoshi Hasegawa, Tatsuo Ohtsuka, Yasuhiko Shiratori, Hidetoshi Shindoh, Ikuo Horii, Shigeyasu Ichihara, Yuko Aoki, Nobuo Shimma
Publikováno v:
Journal of Chemical Information and Computer Sciences. 42:968-975
Pharmacokinetic (PK) parameters of N-myristoyltransferase (Nmt) inhibitors were measured, and a multivariate quantitative structure-pharmacokinetic relationship (QSPKR) model for predicting rat elimination half-life (t(1/2)) values was constructed. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e72937168fb64e0c622afadefb1fa8
https://doi.org/10.1021/ci0102517
https://doi.org/10.1021/ci0102517
Autor:
Ikuo Horii, C. Konishi, K. Kobayashi, J.F. Eliason, R. Sawada, Shigeyasu Ichihara, Isami Kuruma, T. Tsukaguchi, H. Ramuz
Publikováno v:
European Journal of Cancer. 31:2354-2361
The multidrug resistance modifying activity of a dithiane analogue of tiapamil, Ro 44-5912, was examined in vivo . Results of acute toxicity studies in mice indicated that lethal toxicity occurred with doses greater than 1 mmol/kg of body weight. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a76072312216498f5c58abe20847ec
https://doi.org/10.1016/0959-8049(95)00418-1
https://doi.org/10.1016/0959-8049(95)00418-1
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 11:379-384
A relatively simple and sensitive high-performance liquid chromatographic (HPLC) method is described for measuring galocitabine (Ro 09-1390) and its meatbolites, i.e. 5'-deoxy-fluorocytidine (5'-DFCR), 5'-deoxy-fluorouridine (5'-DFUR) and 5-fluoroura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059915e472d4c4a4aba3a733d4d41bd5
https://doi.org/10.1016/0731-7085(93)80032-v
https://doi.org/10.1016/0731-7085(93)80032-v
Autor:
Kiyoshi Hasegawa, Shigeyasu Ichihara, Yasuhiko Shiratori, Nobuo Shimma, Yuko Aoki, Hidetoshi Shindoh, Tatsuo Ohtsuka, Ikuo Horii
Publikováno v:
ChemInform. 33
Pharmacokinetic (PK) parameters of N-myristoyltransferase (Nmt) inhibitors were measured, and a multivariate quantitative structure−pharmacokinetic relationship (QSPKR) model for predicting rat elimination half-life (t1/2) values was constructed. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20182efe13bfd064b4b6f00ba264f3e5
https://doi.org/10.1002/chin.200242248
https://doi.org/10.1002/chin.200242248
Autor:
Nobuhiro Oikawa, Toshikazu Yamazaki, Masao Tsukazaki, Tadakatsu Nippon Roche Shonan Dor. R.A Hayase, Yoshiaki Isshiki, Masahiro Sakaitani, Yasuhiko Shiratori, Isao Umeda, Jun Ohwada, Shigeyasu Ichihara, Nobuo Shimma, Hiroshi Fukuda, Eisaku Mizuguchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(2)
A highly potent water soluble triazole antifungal prodrug, RO0098557 (1), has been identified from its parent, the novel antifungal agent RO0094815 (2). The prodrug includes a triazolium salt linked to an aminocarboxyl moiety, which undergoes enzymat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e7a3a2ed6f5b4ee56886fa80df8f9d
https://pubmed.ncbi.nlm.nih.gov/12482421
https://pubmed.ncbi.nlm.nih.gov/12482421
Autor:
Akiyoshi Fukamizu, Junko Kimura, Setsuo Morishita, Junji Ishida, Shigeyasu Ichihara, Juri Hamada, Takeo Kohda
Publikováno v:
International Journal of Molecular Medicine. 22
Apelin regulates various cell signaling processes through interaction with its specific cell-surface receptor, APJ, which is a member of a seven transmembrane G protein-coupled receptor superfamily. To develop a novel apelin analogue, we synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fdd32e22aa358032d27c4b1145a5b3
https://doi.org/10.3892/ijmm_00000054
https://doi.org/10.3892/ijmm_00000054
Publikováno v:
Biochimica et biophysica acta. 1118(1)
We derived an equation which describes the plot of the remaining enzyme activity versus ratio of initial concentration of suicide substrate to that of enzyme to obtain a partition ratio from the time-course of remaining enzyme activity. The simulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7b448cef5efce46589e0e3c39fb350
https://pubmed.ncbi.nlm.nih.gov/1764474
https://pubmed.ncbi.nlm.nih.gov/1764474
Autor:
Shigeyasu Ichihara, N Ichimoto, Mitsuru Tateishi, Hiroki Tomisawa, Hideo Fukazawa, I Yamamoto
Publikováno v:
Biochemical Journal. 235:569-575
Cysteine-conjugate beta-lyase (EC 4.4.1.13) was purified about 880-fold from human liver obtained post mortem. The purification procedure included (NH4)2SO4 precipitation, chromatography on DEAE-cellulose and hydroxyapatite, gel filtration on Sephade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e8153e650925019beaed4288dd5258
https://doi.org/10.1042/bj2350569
https://doi.org/10.1042/bj2350569
Autor:
Hiroki Tomisawa, Akiharu Fujino, Yusaku Ohtani, Hideo Fukazawa, Hiroko Saitoh, Tae Yajima, Shigeyasu Ichihara, Mitsuru Tateishi, Noriko Ichimoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 1:61-67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a1b0ce7fb51606e516390fd2b4c3d16
https://doi.org/10.2133/dmpk.1.61
https://doi.org/10.2133/dmpk.1.61