Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Shigeto, Hirayama"'
Autor:
Fumika Karaki, Taro Takamori, Koumei Kawakami, Sae Sakurai, Kyoko Hidaka, Kei Ishii, Tomoya Oki, Noriko Sato, Nao Atsumi, Karin Ashizawa, Ai Taguchi, Asuka Ura, Toko Naruse, Shigeto Hirayama, Miki Nonaka, Kanako Miyano, Yasuhito Uezono, Hideaki Fujii
Publikováno v:
Molecules, Vol 28, Iss 19, p 6925 (2023)
In medicinal chemistry, the copper-catalyzed click reaction is used to prepare ligand candidates. This reaction is so clean that the bioactivities of the products can be determined without purification. Despite the advantages of this in situ screenin
Externí odkaz:
https://doaj.org/article/c6cdea6301e74fd5814806febc9d810e
Autor:
Masahiro Yamaguchi, Kanako Miyano, Shigeto Hirayama, Yusuke Karasawa, Kaori Ohshima, Eiko Uezono, Akane Komatsu, Miki Nonaka, Hideaki Fujii, Keisuke Yamaguchi, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono
Publikováno v:
Molecules, Vol 27, Iss 20, p 7065 (2022)
Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects. The selective κOR agonist nalfurafine was initi
Externí odkaz:
https://doaj.org/article/a7b83951f1a546df8ff51977d03aab6c
Autor:
Yoshiyuki Meguro, Kanako Miyano, Shigeto Hirayama, Yuki Yoshida, Naoto Ishibashi, Takumi Ogino, Yuriko Fujii, Sei Manabe, Moeko Eto, Miki Nonaka, Hideaki Fujii, Yoichi Ueta, Minoru Narita, Naohiro Sata, Toshihiko Yada, Yasuhito Uezono
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 1, Pp 67-75 (2018)
Oxytocin (OT) is a 9-amine neuropeptide that plays an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. OT has been reported to exert an analgesic effect in both humans and animals, and the results of certain ani
Externí odkaz:
https://doaj.org/article/ada2822084344d58bf01721fd9bc8ca1
Autor:
Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono
Publikováno v:
Cells, Vol 10, Iss 10, p 2651 (2021)
Oxytocin (OT) influences various physiological functions such as uterine contractions, maternal/social behavior, and analgesia. Opioid signaling pathways are involved in one of the analgesic mechanisms of OT. We previously showed that OT acts as a po
Externí odkaz:
https://doaj.org/article/f806c283bdad47eeb3f6f5b335c65459
Autor:
Chiharu Iwamatsu, Daichi Hayakawa, Tomomi Kono, Ayaka Honjo, Saki Ishizaki, Shigeto Hirayama, Hiroaki Gouda, Hideaki Fujii
Publikováno v:
Molecules, Vol 25, Iss 17, p 3792 (2020)
We have recently reported that N-alkyl and N-acyl naltrindole (NTI) derivatives showed activities for the δ opioid receptor (DOR) ranging widely from full inverse agonists to full agonists. We newly designed sulfonamide-type NTI derivatives in order
Externí odkaz:
https://doaj.org/article/a86587e5a06c412c82bbc9af530502ee
Autor:
Fumika Karaki, Yuma Sakao, Shigeto Hirayama, Kanako Miyano, Tomoya Oki, Hideaki Fujii, Yasuhito Uezono, Noriko Sato
Publikováno v:
ChemMedChem. 16:3463-3476
Ghrelin is a pleiotropic feeding hormone which also has a pivotal role in the central nervous system. Upon the activation of its receptor, growth hormone secretagogue receptor (GHSR), the Gα q/11 -mediated and the β-arrestin-mediated signaling path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ef599eece4a0be68690826e759c4b9
https://doi.org/10.1002/cmdc.202100322
https://doi.org/10.1002/cmdc.202100322
Autor:
Shigeto Hirayama, Hideaki Fujii
Publikováno v:
Current Topics in Medicinal Chemistry. 20:2889-2902
The discovery of δ opioid receptor inverse agonist activity induced by ICI-174,864, which was previously reported as an δ opioid receptor antagonist, opened the door for the investigation of inverse agonism/constitutive activity of the receptors. V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680593e860bd695509d91bcd3156ff7b
https://doi.org/10.2174/1568026620666200402115654
https://doi.org/10.2174/1568026620666200402115654
Autor:
Hideaki Fujii, Atsushi Ohtsuka, Shunsuke Sawamura, Mizuki Kobe, Ken Tokunaga, Kennosuke Itoh, Hitoshi Ishida, Yasunori Toda, Ryo Kato, Takaaki Mizuguchi, Noriko Sato, Hiroyuki Suga, Fumika Karaki, Atsushi Takashino, Shigeto Hirayama
Publikováno v:
ChemPhotoChem. 4:388-392
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b56726d56cd244daf78309c6a5f09848
https://doi.org/10.1002/cptc.202000004
https://doi.org/10.1002/cptc.202000004
Autor:
Hideaki Fujii, Kennosuke Itoh, Sho Ito, Shun-ichi Nagao, Ken Tokunaga, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Yoshio Shibagaki, Masashi Hashimoto
Publikováno v:
HETEROCYCLES. 104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::772dd14727443b1ea3b0011860eccb64
https://doi.org/10.3987/com-22-14747
https://doi.org/10.3987/com-22-14747
Autor:
Yuka Uenohara, Saori Tsumura, Shigeto Hirayama, Eika Higashi, Yurie Watanabe, Hiroaki Gouda, Hiroshi Nagase, Hideaki Fujii
Publikováno v:
Bioorganicmedicinal chemistry. 53
The κ opioid receptor (KOR) is one of the promising targets to develop analgesics lacking morphine like side effects. To seek a novel KOR agonist we designed 6-amide derivatives with an oxabicyclo[3.2.1]octane structure based on a proposed active co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281db4186b3e8de01a53d2d689f42efb
https://pubmed.ncbi.nlm.nih.gov/34894610
https://pubmed.ncbi.nlm.nih.gov/34894610