Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Shigetada Kozai"'
Autor:
Graciella Andrei, Yosuke Demizu, Tokumi Maruyama, Christophe Pannecouque, Myriam Witvrouw, Jan Balzarini, Shigetada Kozai, Robert Snoecks, Erik De Clercq
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 26:1553-1558
Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e76dfd6df77bc71cab0d5509383477
https://doi.org/10.1080/15257770701545424
https://doi.org/10.1080/15257770701545424
Autor:
Erik De Clercq, Shigetada Kozai, Robert Snoeck, Myriam Witvrouw, Tokumi Maruyama, Christophe Pannecouque, Graciella Andrei, Jan Balzarini, Tetsuo Yamasaki
Publikováno v:
ResearcherID
The development of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) is an efficient strategy for finding new therapeutic agents against human immunodeficiency virus (HIV). A large number of 6-substituted uracil derivatives have been prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0f6ccd223fc45eae5493db0b383ce2
https://doi.org/10.1177/095632020301400506
https://doi.org/10.1177/095632020301400506
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 21:765-774
The protected analogue of 2-amnio-6-chloropurine arabinoside (3b) was subjected to reaction with diethylaminosulfur trifluoride (DAST) and subsequently treated with NaOAc in Ac2O/AcOH to give N 2,O 3′,O 5′-triacetyl-2′-deoxy-2′-fluoroguanosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94369389992655295ffac1c40e3d971
https://doi.org/10.1081/ncn-120016479
https://doi.org/10.1081/ncn-120016479
Publikováno v:
Tetrahedron Letters. 43:2633-2636
N3-Benzyluracil was treated with N-hydroxymethylphthalimide in the presence of the Mitsunobu reagent to give an unusual product bearing a hydrazylmethyl group ( 2 ) and/or the condensate ( 3 ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28f62cbde93f492ad7a19c904cab3fd
https://doi.org/10.1016/s0040-4039(02)00301-5
https://doi.org/10.1016/s0040-4039(02)00301-5
Publikováno v:
Tetrahedron. 56:7685-7690
Theophylline was converted to 7-(2-phenyl-2-methanesulfonyloxy)ethyl congener and the product was treated with ammonia or primary amines in a mixture solution of water and organic solvents. Two products were proven to be the styrene analogue and 7-(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb7a3204658da9e94388a4a61a7d88a
https://doi.org/10.1016/s0040-4020(00)00683-9
https://doi.org/10.1016/s0040-4020(00)00683-9
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:1193-1203
A general procedure to obtain tetra-substituted uric acid by stepwise N-alkylation is described. 2,6-Dichloropurine (1) was condensed with 1-propanol by Mitsunobu reaction to give 9-propyl congener (2). Treatment of 2 with ammonia gave adenine deriva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c654a0fad364ba25f185546abec9157
https://doi.org/10.1080/15257770008035040
https://doi.org/10.1080/15257770008035040
Publikováno v:
Nucleosides and Nucleotides. 18:2433-2442
After 3′, 5′-di-O-protection of 8-bromoadenosine, the product was converted to the arabinoside, which was successively treated with diethylaminosulfur trifluoride (DAST) and acid to afford 8-bromo-2′-deoxy-2′-fluoroadenosine. However, the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31bc4be9c8c195d42ae23de62cdf454e
https://doi.org/10.1080/07328319908044618
https://doi.org/10.1080/07328319908044618
Publikováno v:
Tetrahedron Letters. 40:4355-4358
A benzoyl group was introduced onto the 3′-hydroxyl group of 6-chloropurine riboside by treatment with benzoylating agents in the presence of an organic or inorganic base in aqueous solution, in which further reaction gave 6-chloropurine 2′,3′-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1096f9a21d54b80f3f6e39c865f8dd89
https://doi.org/10.1016/s0040-4039(99)00747-9
https://doi.org/10.1016/s0040-4039(99)00747-9
Publikováno v:
Nucleosides and Nucleotides. 18:661-671
1-Benzyluracils 2a,b were treated with iodobenzene in the presence of cuprous oxide in 2,4,6-trimethylpyridine at 180°C to give the N 1-phenyl derivatives 3a and 3b in 47% and 55%, respectively. Similar reaction of 2a with 2-bromopyridine at 120°C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e3bfbbbfb919cb602aabe16d5966d58
https://doi.org/10.1080/15257779908041534
https://doi.org/10.1080/15257779908041534
Autor:
Tokumi Maruyama, Yoshiko Satoh, Kunisuke Kawasaki-shi Izawa, Satoshi Takamatsu, Shigetada Kozai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:966-970
A facile and practicam method to infroduce fluorine at the up-side of the 2'-carbon of nucleosides is described. 6-Chloropurine riboside 3 was converted to the 3'-O-benzoate 4a via a stannylene complex, then converted to the 3'-O-benzoyl-5'-O-tritylr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e4066efa64cf1dc7ba203411144dee3
https://doi.org/10.1248/cpb.47.966
https://doi.org/10.1248/cpb.47.966