Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shigeru Tabata"'
Autor:
Takesada Shimura, Taishi Okagawa, Shigeru Tabata, Takuya Fujita, Shozo Muranishi, Akira Yamamoto, Masahiro Murakami, Shuji Kondo
Publikováno v:
Life Sciences. 55:677-683
In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7ccd9b94155394138793e71b9dce67
https://doi.org/10.1016/0024-3205(94)00674-1
https://doi.org/10.1016/0024-3205(94)00674-1
Publikováno v:
Drug Investigation. 4:528-534
A new metabolic pathway for felodipine was confirmed by identification and quantification of new felodipine metabolites retaining the dihydropyridine structure. Following administration of a 10mg dose to 6 healthy subjects, felodipine was rapidly abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da880cc4b5ab92f06c745311831f23f
https://doi.org/10.1007/bf03259219
https://doi.org/10.1007/bf03259219
Autor:
Akira Saheki, Tetsuya Terasaki, Shuzo Moritani, Akira Tsuji, Susumu Takakuwa, Takesada Shimura, Shigeru Tabata
Publikováno v:
Pharmaceutical Research. :529-534
The internalization of a neuromodulatory adrenocorticotropic hormone (ACTH) analogue, [125I]ebiratide (H-Met(O2)-Glu[125I]His-Phe-D-Lys-Phe-NH(CH2)8NH2), was examined in cultured mono-layers of bovine brain capillary endothelial cells (BCEC). HPLC an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d0e0be54216520d19417d33df509b7e
https://doi.org/10.1023/a:1015848531603
https://doi.org/10.1023/a:1015848531603
Autor:
Hisako Ishikawa, Kazuo Uno, Yoshio Esumi, Shuji Kondo, Matsuo Takaichi, Yoshitaka Jin, Satoru Yamagami, Shigeru Tabata, Sadao Tsuri
Publikováno v:
Drug Metabolism and Pharmacokinetics. 7:243-255
Two novel metabolites of felodipine were isolated from rat bile or in an in vitro system using rat liver preparations. Their chemical structures were identified by comparative analysis with authentic samples. Both metabolites were formed by ester hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed238baf2c3e1bf9c796fa2c78dc4b6
https://doi.org/10.2133/dmpk.7.243
https://doi.org/10.2133/dmpk.7.243
Publikováno v:
Peptides. 12:509-512
The transfer of ebiratide into the brain was examined in rats. Its brain levels after intravenous administration (2–20 mg/kg), determined by radioimmunoassay, peaked at 5 min and declined almost in parallel with the plasma levels. Brain/plasma rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030ea002238c954264eff7e19d64c0bd
https://doi.org/10.1016/0196-9781(91)90093-5
https://doi.org/10.1016/0196-9781(91)90093-5
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 565:237-246
A novel method for the determination of felodipine and its metabolites in plasma by capillary gas chromatography (GC) with electron capture detection was developed. Felodipine and its oxidized metabolite were assayed by capillary GC after solid-phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d36d16d6be7154415353ffd76ed51b5
https://doi.org/10.1016/0378-4347(91)80386-q
https://doi.org/10.1016/0378-4347(91)80386-q
Autor:
Shigeru Tabata, Syoryo Hayashi, Yoshitaka Jin, Yoshio Esumi, Sadao Tsuji, Matsuo Takaichi, Kazuo Uno, Satoru Yamagami, Hisako Ishikawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:749-767
The absorption, distribution, metabolism, and excretion of 14C-Felodipine were investigated during and after its repeated oral administration to male rats at a daily dose of 1mg/kg for 28 days. 1. The concentration of radioactivity in the blood (24hr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b7b114be0c59ee2c02b811c0554f52
https://doi.org/10.2133/dmpk.6.749
https://doi.org/10.2133/dmpk.6.749
Autor:
Yoshio Esumi, Matsuo Takaichi, Sadao Tsuji, Syoryo Hayashi, Yoshitaka Jin, Shigeru Tabata, Satoru Yamagami, Kazuo Uno, Hisako Ishikawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:717-747
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::721bc0f01e26f1ceee44d8da05e6d024
https://doi.org/10.2133/dmpk.6.717
https://doi.org/10.2133/dmpk.6.717
Autor:
Yoshitaka Jin, Syoryo Hayashi, Shigeru Tabata, Kazuo Uno, Matsuo Takaichi, Satoru Yamagami, Hisako Ishikawa, Yoshio Esumi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:769-779
The distribution of radioactivity in fetuses and the transfer to milk were investigated after oral administration of 14C-Felodipine 1mg/kg to pregnant or lactating rats. Distribution in blood cells and the protein binding of radioactivity were also s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39febc2e53f9d489d32b7c7502f97a69
https://doi.org/10.2133/dmpk.6.769
https://doi.org/10.2133/dmpk.6.769
Publikováno v:
Drug Metabolism and Pharmacokinetics. 5:323-330
A specific radioimmunoassay method was developed for H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2(ebiratide)., an analogue of adrenocorticotropic hormone. The sensitivity was 30pg/ml. Recovery of ebiratide from plasma was almost 100%, and the intra a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd89ce659b1fb1a02b0f67559ce341bb
https://doi.org/10.2133/dmpk.5.323
https://doi.org/10.2133/dmpk.5.323