Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Shigeru Okuya"'
Autor:
Syota Kagawa, Katsuya Tanabe, Makoto Hiromura, Kakuyou Ogawa, Takayuki Koga, Takahiro Maeda, Kikuko Amo-Shiinoki, Hiroyuki Ochi, Yui Ichiki, Shogo Fukuyama, Saori Suzuki, Natsuki Suizu, Takaaki Ohmine, Sakurako Hamachi, Hiroshi Tsuneki, Shigeru Okuya, Toshiyasu Sasaoka, Yukio Tanizawa, Fumihiro Nagashima
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Hachimijiogan (HJG) has originally been used to ameliorate a variety of symptoms associated with low ambient temperatures. However, its pharmacological action in metabolic organs remains unclear. We hypothesized that HJG may modulate metabolic functi
Externí odkaz:
https://doaj.org/article/6a843b8816024421a6964c11f6afff37
Autor:
Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanabe
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13586 (2022)
Endoplasmic reticulum (ER) stress is a key pathogenic factor in type 1 and 2 diabetes. Glycogen synthase kinase 3 (Gsk-3) contributes to β-cell loss in mice. However, the mechanism by which Gsk-3 leads β-cell death remains unclear. ER stress was ph
Externí odkaz:
https://doaj.org/article/e71b6ccf4b404e5fb6f53ddccf2dd018
Autor:
Kikuko Amo-Shiinoki, Katsuya Tanabe, Yoshinobu Hoshii, Hiroto Matsui, Risa Harano, Tatsuya Fukuda, Takato Takeuchi, Ryotaro Bouchi, Tokiyo Takagi, Masayuki Hatanaka, Komei Takeda, Shigeru Okuya, Wataru Nishimura, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Tetsuya Yamada, Yoshihiro Ogawa, Eiji Ikeda, Hiroaki Nagano, Yukio Tanizawa
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese sub
Externí odkaz:
https://doaj.org/article/92a308a1444447e78710fef4553a9fd9
Autor:
Kimie Matsunaga, Katsuya Tanabe, Hiroshi Inoue, Shigeru Okuya, Yasuharu Ohta, Masaru Akiyama, Akihiko Taguchi, Yukari Kora, Naoko Okayama, Yuichiro Yamada, Yasuhiko Wada, Shin Amemiya, Shigetaka Sugihara, Yuzo Nakao, Yoshitomo Oka, Yukio Tanizawa
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106906 (2014)
BACKGROUND: Wolfram syndrome (WFS) is a recessive neurologic and endocrinologic degenerative disorder, and is also known as DIDMOAD (Diabetes Insipidus, early-onset Diabetes Mellitus, progressive Optic Atrophy and Deafness) syndrome. Most affected in
Externí odkaz:
https://doaj.org/article/24509e5a11404243807f239b76ed7a91
Autor:
Tetsuya Yamada, Tatsuya Fukuda, Yoshinobu Hoshii, Ryotaro Bouchi, Takato Takeuchi, Yukio Tanizawa, Shigeru Okuya, Shinji Tanaka, Hiroaki Nagano, Tokiyo Takagi, Katsuya Tanabe, Takumi Akashi, Masayuki Hatanaka, Komei Takeda, Yoshihiro Ogawa, Kikuko Amo-Shiinoki, Wataru Nishimura, Minoru Tanabe, Eiji Ikeda, Risa Harano, Hiroto Matsui, Atsushi Kudo
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
JCI Insight
Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese sub
Publikováno v:
Psychiatry research. 295
To clarify the risk factors for suicide among university students, we collected the data of students who died of any cause from 1992 to 2017 from the accident records of the Yamaguchi University. Sociodemographic and clinical data from the health exa
Autor:
Kimie Matsunaga, Ichiro Kunitsugu, Ryuta Nomiyama, Kyoko Ariyoshi, Shigeru Okuya, Yukio Tanizawa, Komei Takeda, Yuko Nagao
Publikováno v:
Journal of Diabetes Investigation
Aims/Introduction Measurements of plaque echogenicity, the gray-scale median (GSM), were shown to correlate inversely with risk factors for cerebro-cardiovascular disease (CVD). The eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is a potenti
Autor:
Yoshitaka Nakamori, Akihiko Taguchi, Masahiro Emoto, Naofumi Fukuda, Michiko Tajiri, Yukio Tanizawa, Kazunari Taira, Yoshinao Wada, Makoto Miyagishi, Shigeru Okuya
Publikováno v:
The Journal of Cell Biology
Tumor necrosis factor-alpha (TNF-alpha) signaling through the IkappaB kinase (IKK) complex attenuates insulin action via the phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser307. However, the precise molecular mechanism by which the IKK
Autor:
Naoko Okayama, Yuzo Nakao, Katsuya Tanabe, Yoshitomo Oka, Kimie Matsunaga, Yuichiro Yamada, Shigeru Okuya, Shigetaka Sugihara, Masaru Akiyama, Yukio Tanizawa, Yukari Kora, Akihiko Taguchi, Shin Amemiya, Hiroshi Inoue, Yasuharu Ohta, Yasuhiko Wada
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106906 (2014)
PLoS ONE
PLoS ONE
Background Wolfram syndrome (WFS) is a recessive neurologic and endocrinologic degenerative disorder, and is also known as DIDMOAD (Diabetes Insipidus, early-onset Diabetes Mellitus, progressive Optic Atrophy and Deafness) syndrome. Most affected ind