Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shigeru Matsuki"'
Autor:
Kazuma Ogiso, Mayumi Otsuji, Nobuyuki Koriyama, Mayumi Kinowaki, Takahiko Goto, Shigeru Matsuki, Ayako Akao, Machiko Minobe, Natsuko Fujisaki
Publikováno v:
Journal of Diabetes and Metabolic Disorders
We herein describe the case of a 29-year-old woman with type 1 diabetes from 10 years of age who developed adult cyclic vomiting syndrome. Beginning at 25 years of age, she was frequently hospitalized for stress-induced vomiting. Her vomiting episode
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:269-273
During 2-aminobenzamide (2-AB)-labeling of sialo-oligosaccharides the authors encountered a significant loss of sialic acids under the reported conditions, at 65 degrees C for 2 h. By examination of the relationship between labeling temperature and r
Autor:
Thomas W. Strickland, Seiichi Takasaki, Tadashi Misaizu, Makoto Takeuchi, Shigeru Matsuki, Akira Kobata
Publikováno v:
Blood. 86:4097-4104
To elucidate the role of the branched structure of sugar chains of human erythropoietin (EPO) in the expression of in vivo activity, the pharmacokinetic profile of a less active recombinant human EPO sample (EPO-bi) enriched with biantennary sugar ch
Autor:
Makoto Kakitani, Rika Satake-Ishikawa, Mayumi Kawagishi, Masaru Kusaka, Yuji Okada, Katsuhiko Asano, Masaharu Ishikawa, Shigeru Matsuki
Publikováno v:
General Pharmacology: The Vascular System. 25:533-537
1. 1. To clarify the pharmacological effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) conjugated to polyethylene glycol (PEG), its effects on the number of circulating neutrophils in mice made neutropenic by cyclophosphami
Autor:
Haruhiko Tsumura, Shigeru Matsuki, Katsuhiko Asano, Yuji Okada, Rika Ishikawa, Masaharu Ishikawa
Publikováno v:
Biotechnology Letters. 15:673-678
Recombinant human granulocyte-colony stimulating factor (rhG-CSF) was modified by site-directed mutagenesis and chemical modification in order to improve its pharmacological activity and its thermostability. The mutant rhG CSF which 17th cysteine was
Autor:
Katsuhiko Asano, Rika Satake-Ishikawa, Hiromi Fukamachi, Keiko Kobayashi, Hiroshi Iijima, Akihiro Iwamatsu, Haruhiko Tsumura, Toshihiko Kadoya, Shigeru Matsuki, Yoshihiro Shimada, Masaharu Ishikawa
Publikováno v:
Cell Structure and Function. 17:61-65
Human recombinant granulocyte-colony stimulating factor (rhG-CSF) has one free cysteine at position 17 and has two disulfide bridges (Cys36-Cys42 and Cys64-Cys74). The Cys17 of rhG-CSF was substituted with Gly, Ala, Ser, Ile, Tyr, Arg, and Pro, or de
Autor:
Katsuhiko Asano, Masaharu Ishikawa, Rika Satake-Ishikawa, Mayumi Kawagishi, Makoto Kakitani, Yuji Okada, Shigeru Matsuki
Publikováno v:
Cell Structure and Function. 17:157-160
Recombinant human granulocyte colony-stimulating factor (rHuG-CSF) produced in Escherichia coil was chemically modified by polyethylene glycol (PEG) of molecular weights 4, 500 or 10, 000. The neutrophils observed at 32 hours after intravenous inject
Mutant protein of recombinant human granulocyte colony-stimulating factor for receptor binding assay
Autor:
Haruhiko Tsumura, Masahiko Watanabe, Hiroya Uzumaki, Masaharu Ishikawa, Shigeru Matsuki, Hiromi Fukamachi, Koji Kabaya, Masaru Kusaka
Publikováno v:
Analytical Biochemistry. 195:38-44
A new mutant protein of recombinant human granulocyte colony-stimulating factor (rhG-CSF) was produced for the studies on receptors for human G-CSF. The mutant protein [(Tyr1, Tyr3]rhG-CSF), the biological activity of which was almost equal to that o
Publikováno v:
The Proceedings of the Annual Convention of the Japanese Psychological Association. 74:2PM093-2PM093
Autor:
Kiyoshi Miyagawa, Fumimaro Takaku, Yun-Feng Piao, K Shibuya, Masaaki Terada, Shigeru Chiba, Shigeru Matsuki, Kohei Miyazono, Jun Yokota
Publikováno v:
Journal of cellular physiology. 143(3)
Receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) were identified on 9 of 35 (26%) human nonhematopoietic tumor cell lines including non-small cell lung cancer, stomach cancer, colon cancer, and osteosarcoma cells. GM-CSF recept