Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shigeru Ieda"'
Autor:
Takumi Takahashi, Ryoki Orii, Shun Hirasawa, Minoru Okada, Koji Kobayashi, Kazuyoshi Obitsu, Shigeru Ieda, Yuji Takahama, Norihiro Ueda, Kazuhiro Takeguchi, Takahiro Akiba, Atsushi Ohigashi
Publikováno v:
Organic Process Research & Development. 23:512-523
Our effort toward the process improvement of anaplastic lymphoma kinase (ALK) inhibitor ASP3026 (1) is described. A cost-effective and practical synthesis of 1 was accomplished as a result of the change of starting material from 2,4-dichloro-1,3,5-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c1bd70225621a79f0a623374a1eafc2
https://doi.org/10.1021/acs.oprd.8b00427
https://doi.org/10.1021/acs.oprd.8b00427
Autor:
Minoru Okada, Hiroshi Takiyama, Kazuhiro Takeguchi, Shun Hirasawa, Shigeru Ieda, Kazuyoshi Obitsu, Ryoki Orii
Publikováno v:
Organic Process Research & Development. 20:970-976
ASP3026 (N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine) was developed as a novel and selective inhibitor of the fusion protein EML4-ALK. Five polymorphs of ASP3026 (A01
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b52ad1c3162912588d9887269da30404
https://doi.org/10.1021/acs.oprd.6b00068
https://doi.org/10.1021/acs.oprd.6b00068
Autor:
Tomohide Nakata, Shinjirou Tanoue, Mitsutaka Matsuura, Minoru Kitayama, Atsushi Ohigashi, Minoru Okada, Akihiro Okada, Yasuhiro Morinaga, Joji Hayashida, Shinya Yoshida, Shoji Mizobata, Takumi Takahashi, Shigeru Ieda, Kazumi Kawai
Publikováno v:
New Horizons of Process Chemistry ISBN: 9789811034206
Here, we describe a challenging scale-up synthesis of the highly functionalized echinocandin ASP9726 (1) starting from the natural product FR901379 (3), the same raw material of micafungin (2). The synthesis demanded various difficult chemoselective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f45a2e050122c8419826c4b8b932093
https://doi.org/10.1007/978-981-10-3421-3_16
https://doi.org/10.1007/978-981-10-3421-3_16
A Challenging Synthesis of the Highly Functionalized Echinocandin ASP9726: A Successor of Micafungin
Autor:
Shinjirou Tanoue, Akihiro Okada, Kazumi Kawai, Atsushi Ohigashi, Yasuhiro Morinaga, Tomohide Nakata, Takumi Takahashi, Joji Hayashida, Shinya Yoshida, Minoru Okada, Mitsutaka Matsuura, Shigeru Ieda, Minoru Kitayama, Shoji Mizobata
Publikováno v:
Organic Process Research & Development. 18:725-738
Here, we describe a practical, scalable, and challenging synthesis of the highly functionalized novel echinocandin ASP9726 (1) starting from the natural product FR901379 (3), which is a starting material of micafungin (2). The synthesis includes tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2eb379e12bf09f7966051b5b53f914c
https://doi.org/10.1021/op500078y
https://doi.org/10.1021/op500078y
Autor:
Yoshinori Okamoto, Souichirou Kawazoe, Ryo Naito, Hirokazu Kubota, Masaki Yokota, Minoru Okada, Makoto Takeuchi, Takeshi Oriyama, Shigeru Ieda
Publikováno v:
Bulletin of the Chemical Society of Japan. 87:127-140
Both (+)- and (−)-4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)-vinyl]phenyl}ethyl)thio]methyl}benzoic acid (1), Thromboxane A2 and Leukotriene D4 receptor dual antagonist ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::487602cb52b68eae12a1a1715ed0b845
https://doi.org/10.1246/bcsj.20130261
https://doi.org/10.1246/bcsj.20130261
Autor:
Norio Hashimoto, Minoru Okada, Yasuhiro Morinaga, Shinya Yoshida, Shigeru Ieda, Atsushi Ohigashi, Takumi Takahashi
Publikováno v:
Organic Process Research & Development. 17:1252-1260
Here, we describe a practical and scalable synthesis of 1, which is a useful side chain of ASP9726 (2), a successor of Micafungin. For large-scale synthesis of 1, reaction conditions were optimized to control impurities and increase yield. In particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94be37a83031f521bccd8a778e8ea708
https://doi.org/10.1021/op400211t
https://doi.org/10.1021/op400211t
Publikováno v:
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 42:147-152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd0b6f0a6cd22b5e53252160f671041
https://doi.org/10.1252/jcej.08we259
https://doi.org/10.1252/jcej.08we259
Autor:
Kazuhiro Takeguchi, Shigeru Ieda, Itsuro Shimada, Kouji Yamazaki, Yutaka Hirakura, Hiroshi Takiyama, Minoru Okada
Publikováno v:
Chemicalpharmaceutical bulletin. 63(6)
ASP3026 (N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine) was developed in Astellas Pharma Inc. as a novel and selective inhibitor of the fusion protein EML4-ALK. We invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372b923401a4a8465aa670664768506d
https://pubmed.ncbi.nlm.nih.gov/26027465
https://pubmed.ncbi.nlm.nih.gov/26027465
Autor:
Shigeru Ieda, Masaki Yokota, Yoshinori Okamoto, Takeshi Oriyama, Hirokazu Kubota, Minoru Okada, Souichirou Kawazoe, Ryo Naito, Makoto Takeuchi
Publikováno v:
ChemInform. 45
Both (+)- and (−)-4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)-vinyl]phenyl}ethyl)thio]methyl}benzoic acid (1), Thromboxane A2 and Leukotriene D4 receptor dual antagonist ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f31c6506888dfd03a3bf650fb8b0b53
https://doi.org/10.1002/chin.201425166
https://doi.org/10.1002/chin.201425166
Publikováno v:
Tetrahedron Letters. 51:4027-4029
Efficient synthesis of the tricyclic key intermediate 2 for (−)-FR901483 1 was accomplished. The precursor of the intramolecular aldol reaction 4b is constructed by the Ugi 4CC reaction and subsequent intramolecular Dieckmann condensation. This app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40c28b8dfb0341f00590f1c683785dc1
https://doi.org/10.1016/j.tetlet.2010.05.089
https://doi.org/10.1016/j.tetlet.2010.05.089