Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Shigeru, Yatoh"'
Autor:
Yasuhiro Suzuki, Hiroaki Suzuki, Tatsuya Ishikawa, Yasunori Yamada, Shigeru Yatoh, Yoko Sugano, Hitoshi Iwasaki, Motohiro Sekiya, Naoya Yahagi, Yasushi Hada, Hitoshi Shimano
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract We aimed to investigate the status of falls and to identify important risk factors for falls in persons with type 2 diabetes (T2D) including the non-elderly. Participants were 316 persons with T2D who were assessed for medical history, labor
Externí odkaz:
https://doaj.org/article/a7b1e405f14d44f2bd4da47baed2a423
Autor:
Motohiro Sekiya, Takaaki Matsuda, Yuki Yamamoto, Yasuhisa Furuta, Mariko Ohyama, Yuki Murayama, Yoko Sugano, Yoshinori Ohsaki, Hitoshi Iwasaki, Naoya Yahagi, Shigeru Yatoh, Hiroaki Suzuki, Hitoshi Shimano
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Renal hypouricemia (RHUC) is a hereditary disorder where mutations in SLC22A12 gene and SLC2A9 gene cause RHUC type 1 (RHUC1) and RHUC type 2 (RHUC2), respectively. These genes regulate renal tubular reabsorption of urates while t
Externí odkaz:
https://doaj.org/article/0f0a62fe77bf4e94b6ab63c2550fa253
Autor:
Manabu Midorikawa, Hiroaki Suzuki, Yasuhiro Suzuki, Kazuyoshi Yamauchi, Hiroyuki Sato, Kiyotaka Nemoto, Yoko Sugano, Hitoshi Iwasaki, Motohiro Sekiya, Shigeru Yatoh, Naoya Yahagi, Yasushi Hada, Tetsuaki Arai, Hitoshi Shimano
Publikováno v:
Journal of Diabetes Research, Vol 2021 (2021)
Aim. We investigated the relationship between cognitive function and olfactory and physical functions in middle-aged persons with and without type 2 diabetes (T2D) to examine the potential of olfactory and physical functions as biomarkers for early c
Externí odkaz:
https://doaj.org/article/bd1e6bc688e04674924b50dcf7b36c83
Autor:
Takuya Kikuchi, Kana Orihara, Fusaka Oikawa, Song-iee Han, Motoko Kuba, Kanako Okuda, Aoi Satoh, Yoshinori Osaki, Yoshinori Takeuchi, Yuichi Aita, Takashi Matsuzaka, Hitoshi Iwasaki, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hiroaki Suzuki, Hirohito Sone, Yoshimi Nakagawa, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1092-1102 (2016)
Objective: The transcription factor cyclic AMP-responsive element-binding protein H (CREBH, encoded by Creb3l3) is highly expressed in the liver and small intestine. Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibro
Externí odkaz:
https://doaj.org/article/9e58a6d6bc0d4359b17de122760090cb
Autor:
Noriko Suzuki-Kemuriyama, Takashi Matsuzaka, Motoko Kuba, Hiroshi Ohno, Song-Iee Han, Yoshinori Takeuchi, Masaaki Isaka, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Katsuhiro Miyajima, Dai Nakae, Naoya Yahagi, Yoshimi Nakagawa, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157580 (2016)
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver cirrhosis and cancer. Recent studies have shown the benefits of cons
Externí odkaz:
https://doaj.org/article/ba72cf7df6544c9194ad881ba3772ffe
Autor:
Hitoshi Shimano, Yoko Sugano, Yuki Yamamoto, Naoya Yahagi, Shigeru Yatoh, Yasuhisa Furuta, Takaaki Matsuda, Motohiro Sekiya, Yuki Murayama, Hiroaki Suzuki, Hitoshi Iwasaki, Mariko Ohyama, Yoshinori Ohsaki
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-9 (2020)
BMC Medical Genetics
BMC Medical Genetics
Background Renal hypouricemia (RHUC) is a hereditary disorder where mutations in SLC22A12 gene and SLC2A9 gene cause RHUC type 1 (RHUC1) and RHUC type 2 (RHUC2), respectively. These genes regulate renal tubular reabsorption of urates while there exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57762f358604d81ad35f34eaa1de1f97
http://link.springer.com/article/10.1186/s12881-020-01031-z
http://link.springer.com/article/10.1186/s12881-020-01031-z
Autor:
Yuta Yamamoto, Saori Koyasu, Motoko Kuba, Yuichi Aita, Yuka Okajima, Kaori Motomura, Naoya Yahagi, Satoru Takahashi, Rahul Sharma, Yoshinori Osaki, Shigeru Yatoh, Hiroaki Suzuki, Yuhei Mizunoe, Hitoshi Iwasaki, Takuya Shimura, Hitoshi Shimano, Yoshimi Nakagawa, Yoshinori Takeuchi, Sundaram Arulmozhiraja, Song-iee Han, Masatsugu Ema, Hiroaki Tokiwa, Takashi Matsuzaka, Takafumi Miyamoto, Motohiro Sekiya, Hiroshi Ohno, Hirohito Sone
Publikováno v:
Hepatology. 71:1609-1625
Background and aims Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. ELOVL fatty ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56aadbb33554895219f13117aea80848
https://doi.org/10.1002/hep.30953
https://doi.org/10.1002/hep.30953
Autor:
Takashi Yamamoto, Kazuhisa Watanabe, Noriyuki Inoue, Yoshimi Nakagawa, Naomi Ishigaki, Takashi Matsuzaka, Yoshinori Takeuchi, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Hiroaki Suzuki, Naoya Yahagi, Takanari Gotoda, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1859-1870 (2010)
Sterol-regulatory element binding protein-1c (SREBP-1c) is a transcription factor that controls lipogenesis in the liver. Hepatic SREBP-1c is nutritionally regulated, and its sustained activation causes hepatic steatosis and insulin resistance. Altho
Externí odkaz:
https://doaj.org/article/c0689a852aa8427f837f1c1e9b427ac3
Autor:
Mayumi Ishikawa, Yuko Iwasaki, Shigeru Yatoh, Toyonori Kato, Shin Kumadaki, Noriyuki Inoue, Takashi Yamamoto, Takashi Matsuzaka, Yoshimi Nakagawa, Naoya Yahagi, Kazuto Kobayashi, Akimitsu Takahashi, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 12, Pp 2524-2534 (2008)
To determine the role of cholesterol synthesis in pancreatic β-cells, a transgenic model of in vivo activation of sterol-regulatory element binding protein 2 (SREBP-2) specifically in β-cells (TgRIP-SREBP-2) was developed and analyzed. Expression o
Externí odkaz:
https://doaj.org/article/905ef0f75800438893c6430ec36aad02