Zobrazeno 1 - 10
of 418
pro vyhledávání: '"Shigeru, OHTA"'
Autor:
Tomoyo Mukai, Yoshi Tsukiyama, Shinobu Yamada, Akinori Nishikawa, Shinya Hayami, Rie Noguchi, Junko Yoshida, Maki Kashiwada, Shigeru Ohta, Toshio Shimokawa, Hiroki Yamaue
Publikováno v:
Palliative Medicine Reports, Vol 4, Iss 1, Pp 214-219 (2023)
Background: Malignancy patients who need long-term hospitalization can feel loneliness affecting their quality of life. The global COVID-19 pandemic has caused visiting restrictions that could mean patients who might be missing out on family support
Externí odkaz:
https://doaj.org/article/4ea963fc6725450384a3549453b98514
Autor:
Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura, Shigeru Ohta
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Background Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels.
Externí odkaz:
https://doaj.org/article/ce6e3b2e3f434a01ad80302182c4c6a3
Autor:
Keishi Ishida, Kazuki Takeda, Yuki Takehara, Tomoki Takabayashi, Masatsugu Miyara, Seigo Sanoh, Hidehiko Kawai, Shigeru Ohta, Yaichiro Kotake
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:292-300
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813d68e4d90ba65505bdac631513c0ae
https://doi.org/10.1248/bpb.b22-00744
https://doi.org/10.1248/bpb.b22-00744
Autor:
Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Hiroyuki Nakajima, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura
Publikováno v:
Heliyon, Vol 5, Iss 9, Pp e02466- (2019)
In this study, we used reporter gene assays in COS-1 cells to examine the activation of rat pregnane X receptor (PXR), rat constitutive androstane receptor (CAR) and rat peroxisome-proliferator activated receptor (PPAR)α by pyrethroid pesticides, an
Externí odkaz:
https://doaj.org/article/3aa936cf2afd4a66a999cf55e88c40cd
Publikováno v:
The Journal of Toxicological Sciences. 47:277-288
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95ddeb4cd8fd3925862d99ddda2ac2db
https://doi.org/10.2131/jts.47.277
https://doi.org/10.2131/jts.47.277
Autor:
Chihiro Sugiyama, Yaichiro Kotake, Masafumi Yamaguchi, Kanae Umeda, Yumi Tsuyama, Seigo Sanoh, Katsuhiro Okuda, Shigeru Ohta
Publikováno v:
Toxicology Reports, Vol 2, Iss C, Pp 450-460 (2015)
In vitro estimating strategies for potential neurotoxicity are required to screen multiple substances. In a previous study, we showed that exposure to low-concentrations of some chemicals, such as organotin, decreased the expression of GluR2 protein,
Externí odkaz:
https://doaj.org/article/119d3130a7834828b08cd92865156cb2
Autor:
Seigo Sanoh, Yoshitaka Tayama, Hiromitsu Watanabe, Ryo Shimizu, Kazumi Sugihara, Shigeru Ohta, Masumi Motonaga, Yaichiro Kotake, Shigeyuki Kitamura
Publikováno v:
BPB Reports. 4:148-154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be8a429c475a35aedf69649fba9a8601
https://doi.org/10.1248/bpbreports.4.5_148
https://doi.org/10.1248/bpbreports.4.5_148
Publikováno v:
Journal of pharmaceutical sciences. 111(11)
The purpose of this study was to investigate the optimal pH for acyl-glucuronidation formation with carboxylic acid-containing compounds in human and rat liver microsomes to improve the predictability of their hepatic clearance. The optimal pH for ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06136c3d3206b9f6e23729e9da56640f
https://pubmed.ncbi.nlm.nih.gov/35995204
https://pubmed.ncbi.nlm.nih.gov/35995204
Publikováno v:
Allergology International, Vol 53, Iss 2, Pp 121-126 (2004)
Background: Because microflora has been reported to have an important effect on the development of allergic disorders, we measured intestinal microflora levels in 4-month-old infants and studied the development of allergic disorders. Methods: Blood s
Externí odkaz:
https://doaj.org/article/7e174daa1f9c41cb852d6430b250b153
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:327-336
Predicting human pharmacokinetics (PK) such as clearance (CL) and volume of distribution (Vd) is a critical component of drug discovery. These predictions are mainly performed by in vitro-in vivo extrapolation (IVIVE) using human biological samples,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7655eca4da0b1acb2b2f0440a4b824
https://doi.org/10.1248/bpb.b18-00754
https://doi.org/10.1248/bpb.b18-00754