Výsledky vyhledávání - "Shigeo HASEGAWA"

Akademický článek

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models

Autor: Shigeo Hasegawa, Sayuri Watanabe, Shinji Fujimoto, Shinichi Kondo, Toshiya Nishi

Publikováno v: Neuroscience Research, Vol 208, Iss , Pp 29-38 (2024)

We investigated whether soticlestat (TAK-935), a newly discovered cholesterol 24-hydroxylase (CH24H) inhibitor now in phase 3 clinical trials for Dravet and Lennox-Gastaut syndromes, has effects on neurodegeneration in both chronic and acute animal m

Externí odkaz: https://doaj.org/article/84dd67a1bba84d8e8ad4d717fe314c39

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Akademický článek

Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain.

Autor: Shigeo Hasegawa, Yuta Kohro, Miho Shiratori, Satoshi Ishii, Takao Shimizu, Makoto Tsuda, Kazuhide Inoue

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10467 (2010)

BACKGROUND: Neuropathic pain is a highly debilitating chronic pain following damage to peripheral sensory neurons and is often resistant to all treatments currently available, including opioids. We have previously shown that peripheral nerve injury i

Externí odkaz: https://doaj.org/article/00029ff141034f47b727eaf7ab215bc8

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[A Case of Stage Ⅳ Triple Negative Breast Cancer(TNBC)in Which S-1 Was Successful against Armor-Like Infiltration of the Chest Wall]

Autor: Shigeo, Hasegawa, Yuko, Kimura, Yoshinori, Nihei, Yasunao, Sai, Tamie, Satou, Takashi, Aiso, Naoki, Takasu, Yukio, Igarashi, Keisuke, Ohnishi, Hiroya, Ohtake

Publikováno v: Gan to kagaku ryoho. Cancerchemotherapy. 49(9)

A 51-year-old female patient visited our department with a complaint of pain in the left breast. She was found to have Stage Ⅳ breast cancer with liver metastasis. The biopsy-based historical diagnosis was triple negative breast cancer(TNBC). Epiru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f0407c74a945104ab6be4897ddca916
https://pubmed.ncbi.nlm.nih.gov/36156018

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Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor

Autor: Toshiya Nishi, Cameron S. Metcalf, Shinji Fujimoto, Shigeo Hasegawa, Maki Miyamoto, Eiji Sunahara, Sayuri Watanabe, Shinichi Kondo, H. Steve White

Publikováno v: Epilepsia. 63(6)

The formation of 24S-hydroxycholesterol is a brain-specific mechanism of cholesterol catabolism catalyzed by cholesterol 24-hydroxylase (CYP46A1, also known as CH24H). CH24H has been implicated in various biological mechanisms, whereas pharmacologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5fc7b5260a91d1b998d234df7d07e8
https://pubmed.ncbi.nlm.nih.gov/35316533

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Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Autor: Momoko Ohori, Etsurou Watanabe, Tsuyoshi Ishi, Jason Yano, Shigeru Kondo, Shinji Fujimoto, Maki Miyamoto, Masato Yoshikawa, Toshiya Nishi, Takanobu Kuroita, Sayuri Watanabe, Haruhi Kamisaki Ando, Eiji Sunahara, William Farnaby, Shigeo Hasegawa, Shinichi Kondo, Tatsuki Koike, Matthew J. During

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports

Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that converts cholesterol into 24S-hydroxycholesterol, the primary mechanism of cholesterol catabolism in the brain. The therapeutic potential of CH24H activation has been extensively inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca7856127e7b3d451e213fd65a9a474
https://doi.org/10.1038/s41598-020-74036-6

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[Total Gastrectomy for Advanced Gastric Cancer after Coronary Artery Bypass Grafting Using the Right Gastroepiploic Artery: Report of a Case]

Autor: Ai, Takahashi, Yukinori, Kamio, Koichiro, Ozawa, Satoshi, Goto, Shigeo, Hasegawa, Masaomi, Mizutani, Takayuki, Higashi, Toshiyuki, Moriya, Moriyoshi, Yokoyama, Kenji, Mase, Osamu, Usuba

Publikováno v: Kyobu geka. The Japanese journal of thoracic surgery. 69(2)

An 82-year-old man, who had undergone coronary artery bypass grafting(CABG) with the right gastroepiploic artery( RGEA) 13 years previously, suffered with abdominal pain after meal and tarry stools, and was diagnosed with advanced gastric cancer. Gas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70cdc1dcd3f94e2d8fbbd731e6b64ccd
https://pubmed.ncbi.nlm.nih.gov/27075160

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