Zobrazeno 1 - 10
of 354
pro vyhledávání: '"Shigeo, Ohta"'
Autor:
Kazuhiro Nomura, Shinichi Kinoshita, Nao Mizusaki, Yoko Senga, Tsutomu Sasaki, Tadahiro Kitamura, Hiroshi Sakaue, Aki Emi, Tetsuya Hosooka, Masahiro Matsuo, Hitoshi Okamura, Taku Amo, Alexander M. Wolf, Naomi Kamimura, Shigeo Ohta, Tomoo Itoh, Yoshitake Hayashi, Hiroshi Kiyonari, Anna Krook, Juleen R. Zierath, Masato Kasuga, Wataru Ogawa
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101968- (2024)
The transcriptional coactivator PGC-1α has been implicated in the regulation of multiple metabolic processes. However, the previously reported metabolic phenotypes of mice deficient in PGC-1α have been inconsistent. PGC-1α exists as multiple isofo
Externí odkaz:
https://doaj.org/article/17003285f15f45a0a37f5fca4575d05c
Autor:
Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, Kuniyuki Kano, Junken Aoki, Goro Katsuumi, Masayoshi Suda, Kazuyuki Ozaki, Yutaka Yoshida, Shujiro Okuda, Shigeo Ohta, Shiki Okamoto, Yasuhiko Minokoshi, Kanako Oda, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura, Yoshiaki Kubota, Norihiko Yoshimura, Shingo Kajimura, Maria Zuriaga, Kenneth Walsh, Tomoyoshi Soga, Tohru Minamino
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Low body temperature predicts a poor outcome in patients with heart failure, but the underlying pathological mechanisms and implications are largely unknown. Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and
Externí odkaz:
https://doaj.org/article/47e7cf28377a4d3a94aefb37d6721e18
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 434 (2023)
(1) Background: Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as anti-oxidant, anti-inflammation, anti-cell death, and the stimulation of
Externí odkaz:
https://doaj.org/article/1542c517266c4cd080bfdc6ecc9ba4fb
Autor:
Shigeo Ohta, Hideaki Oda, Giovanni Manfredi, Jennifer Q. Kwong, Kazutoshi Nakano, Takashi Kanamori, Kumi Yamagata, Yujiro Shidara
Supplementary Figure 1 from Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e301e0e0397b47faec4933326591907
https://doi.org/10.1158/0008-5472.22364387
https://doi.org/10.1158/0008-5472.22364387
Autor:
Shigeo Ohta, Hideaki Oda, Giovanni Manfredi, Jennifer Q. Kwong, Kazutoshi Nakano, Takashi Kanamori, Kumi Yamagata, Yujiro Shidara
The role of mitochondrial dysfunction in cancer has been a subject of great interest and much ongoing investigation. Although most cancer cells harbor somatic mutations in mitochondrial DNA (mtDNA), the question of whether such mutations contribute t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a70c6e1882c7ca42cfe5e640accdb68
https://doi.org/10.1158/0008-5472.c.6494165
https://doi.org/10.1158/0008-5472.c.6494165
Autor:
Naomi Kamimura, Alexander M. Wolf, Takashi Yokota, Chikako Nito, Hiroshi Takahashi, Shigeo Ohta
Publikováno v:
Biochimica et biophysica acta. General subjects. 1867(3)
Oxidative stress is involved in the progression of diabetes and its associated complications. However, it is unclear whether increased oxidative stress plays a primary role in the onset of diabetes or is a secondary indicator caused by tissue damage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c460989dca88dc02c52178a272ceaf0
https://pubmed.ncbi.nlm.nih.gov/36577487
https://pubmed.ncbi.nlm.nih.gov/36577487
Autor:
Masataka Yokoyama, Sho Okada, Atsushi Nakagomi, Junji Moriya, Ippei Shimizu, Aika Nojima, Yohko Yoshida, Harumi Ichimiya, Naomi Kamimura, Yoshio Kobayashi, Shigeo Ohta, Marcus Fruttiger, Guillermina Lozano, Tohru Minamino
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1691-1703 (2014)
Accumulating evidence has suggested a role for p53 activation in various age-associated conditions. Here, we identified a crucial role of endothelial p53 activation in the regulation of glucose homeostasis. Endothelial expression of p53 was markedly
Externí odkaz:
https://doaj.org/article/500b52a3051541269b0055198f3a8159
Autor:
Shigeo Ohta
Publikováno v:
Current Pharmaceutical Design. 27:595-609
Molecular hydrogen (H2) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H2 exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H2 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17d42e52f1f62bcbc9faeedcc6d70b1
https://doi.org/10.2174/18734286mta4podc24
https://doi.org/10.2174/18734286mta4podc24
Autor:
Hirohisa Ono, Yoji Nishijima, Masaki Sakamoto, Soitirou Kitamura, Yuitiou Naitoh, Keiko Suzuki, Norio Fujii, Ryouta Kikura, Shigeo Ohta
Publikováno v:
Medical Research Archives. 10
Introduction: Molecular hydrogen (H2) has emerged as a therapeutic medical gas that exerts multiple functions. H2 inhalation has been approved as safe, and some clinical studies showed that it effectively improved conditions of patients with a variet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60ad8388623c4c401755429ae57bd057
https://doi.org/10.18103/mra.v10i7.2951
https://doi.org/10.18103/mra.v10i7.2951
Publikováno v:
Medical Gas Research. 13:41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1e5946f67b9f1f8f603451e10932c4c
https://doi.org/10.4103/2045-9912.356472
https://doi.org/10.4103/2045-9912.356472