Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Shigeo, Matsuda"'
Autor:
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L. S. Willoughby, Nate Taneja, Jonathan O’Shea, Anna Bisbe, Rajar M. Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A. Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K. Nair, Klaus Charisse, Martin A. Maier, Kallanthottathil G. Rajeev, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of Medicinal Chemistry. 66:2506-2523
Autor:
Dale C. Guenther, Shohei Mori, Shigeo Matsuda, Jason A. Gilbert, Jennifer L. S. Willoughby, Sarah Hyde, Anna Bisbe, Yongfeng Jiang, Saket Agarwal, Mimouna Madaoui, Maja M. Janas, Klaus Charisse, Martin A. Maier, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of the American Chemical Society. 144:14517-14534
Autor:
Anna Bisbe, Martin Maier, Tuyen Nguyen, Martin Egli, Jennifer L. S. Willoughby, Muthiah Manoharan, Ivan Zlatev, Masaaki Akabane-Nakata, Matt Hettinger, Shigeo Matsuda, Hartmut Jahns, Christopher R. Brown, Nate Taneja, Rajar M. Manoharan, Kallanthottathil G. Rajeev, Klaus Charisse
Publikováno v:
Nucleic Acids Research. 50:1221-1240
A critical challenge for the successful development of RNA interference-based therapeutics therapeutics has been the enhancement of their in vivo metabolic stability. In therapeutically relevant, fully chemically modified small interfering RNAs (siRN
Autor:
Mark K Schlegel, Derek K O'Flaherty, Maja M. Janas, Jason A. Gilbert, Namrata D. Erande, Ivan Zlatev, Shigeo Matsuda, Yongfeng Jiang, June Qin, Pawan Kumar, Rohan Degaonkar, Martha Mendez, Masaaki Akabane-Nakata, Muthiah Manoharan, Martin Egli, Lauren Blair Woods
Publikováno v:
Nucleic Acids Research
We recently reported the synthesis of 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides, which are based on a bicyclo[3.1.0]hexane scaffold. Here, we analyzed RNAi-mediated gene silencing activity in cell culture and demonstrated
Autor:
Ryan Malone, Christopher S. Theile, Scott Lentini, Muthusamy Jayaraman, Mikyung Yu, Varun Goel, Rubina G. Parmar, Vasant Jadhav, Shigeo Matsuda, Mark K Schlegel, Guo He, Dennis Brown, June Qin, Swati Gupta, Timothy Racie, Svetlana Shulga-Morskaya, Anil V. Nair, Muthiah Manoharan, Jayaprakash K. Nair, Karyn Schmidt, Azar Shahraz, Ivan Zlatev, Christopher R. Brown, Martin Maier
Publikováno v:
Nucleic Acids Research
One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the remarkable durability of silencing that can persist for months in preclinical species and humans. Here, we investigated the underlying biology supporting this extended
Autor:
Masaaki Akabane-Nakata, Tyler Chickering, Joel M. Harp, Mark K. Schlegel, Shigeo Matsuda, Martin Egli, Muthiah Manoharan
Publikováno v:
Organic letters. 24(2)
Toward the goal of evaluation of carbocyclic ribonucleoside-containing oligonucleotide therapeutics, we developed convenient, scalable syntheses of all four carbocyclic ribonucleotide phosphoramidites and the uridine solid-support building block. Cry
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
Autor:
Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia I. Anglero-Rodriguez, Lan T. H. Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature biotechnology. 40(10)
Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent
Autor:
John Szeto, Adam Castoreno, Muthiah Manoharan, Daniel Berman, Sally Schofield, Klaus Charisse, Christopher R. Brown, Shigeo Matsuda, Joel M. Harp, Mark K Schlegel, Joseph D. Barry, Martin Maier, Martin Egli
Publikováno v:
Nucleic Acids Research
We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc–siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a s
Autor:
Krishna Aluri, Laura Sepp-Lorenzino, Christopher R. Brown, Kevin Fitzgerald, Akin Akinc, Martin Maier, Lauren Blair, Peter F Smith, Ju Liu, Jing Li, Ramesh Indrakanti, Biplab Das, Xiumin Liu, Ivan Zlatev, Scott A Barros, Kallanthottathil G. Rajeev, Yongfeng Jiang, Saket Agarwal, Akshay Vaishnaw, Chris Tran, Klaus Charisse, Jingxuan Liu, Muthiah Manoharan, Shigeo Matsuda, Jayaprakash K. Nair, Jessica E. Sutherland, Tracy Zimmermann, Yuanxin Xu, Jing-Tao Wu, Wendell P Davis, Xuemei Zhang, Maja M. Janas, Vasant Jadhav, Mark K Schlegel
Publikováno v:
Nucleic Acids Research
For oligonucleotide therapeutics, chemical modifications of the sugar-phosphate backbone are frequently used to confer drug-like properties. Because 2′-deoxy-2′-fluoro (2′-F) nucleotides are not known to occur naturally, their safety profile wa