Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Shigenori Yagi"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and re
Externí odkaz:
https://doaj.org/article/7c2f17bac5f94a118eb826a1c4de17ce
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and reduces vas
Autor:
Minoru Tomida, Kosuke Anan, Shoichi Yamamoto, Shunji Shinohara, Aya Tazawa, Nobuyoshi Hasebe, Shigenori Yagi, Masaharu Kume, Shinji Shimada, Yoshihiro Haga, Moriyasu Masui, Hiroyuki Kai, Hiroki Tsuji
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1143-1147
Selective N-methyl- d -aspartate receptor subunit 2B (NR2B) antagonists show potential as analgesic drugs, and do not cause side effects associated with non-selective N-methyl- d -aspartate (NMDA) antagonists. Using a scaffold-hopping approach, we pr
Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and reduces vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb2ca80f3fd487c98a4496e0b352e7e
https://doi.org/10.21203/rs.3.rs-244826/v1
https://doi.org/10.21203/rs.3.rs-244826/v1
Autor:
Hiroyuki, Kai, Tohru, Horiguchi, Takayuki, Kameyama, Kentaro, Asahi, Takeshi, Endoh, Sae, Jikihara, Tsuyoshi, Hasegawa, Satoru, Tanaka, Azusa, Nozu, Chie, Takeyama, Maki, Tomari, Fumiyo, Takahashi, Naomi, Tamura, Shigenori, Yagi, Tetsuji, Itoh, Yasuyoshi, Isou
Publikováno v:
Bioorganicmedicinal chemistry letters. 37
P2X
Autor:
Maki Tomari, Sae Jikihara, Fumiyo Takahashi, Takeshi Endoh, Tetsuji Itoh, Takayuki Kameyama, Yasuyoshi Isou, Hiroyuki Kai, Azusa Nozu, Tohru Horiguchi, Tsuyoshi Hasegawa, Kentaro Asahi, Satoru Tanaka, Naomi Tamura, Shigenori Yagi, Chie Takeyama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 37:127833
P2X3 receptor is an ATP-gated ion channel, mainly localized on peripheral sensory neurons. Currently, several clinical trials are being conducted with P2X3 receptor antagonists for the treatment of chronic pain or cough. To identify a P2X3 lead compo
Autor:
Yasuhiko Kanda, Maki Tomari, Tohru Horiguchi, Kayoko Hata, Hiroyuki Kai, Emiko Taniguchi, Tsuyoshi Hasegawa, Shunji Shinohara, Takayuki Kameyama, Yoshiyuki Taoda, Miho Oohara, Shinji Shimada, Yukio Takahara, Yoshikazu Tanaka, Naoko Kurihara, Yukio Tada, Hiroyuki Tobinaga, Chie Takeyama, Shigenori Yagi, Shoichi Yamamoto, Fumiyo Takahashi, Kentarou Asahi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127636
The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit comp
Autor:
Takeshi Endoh, Chie Takeyama, Yasuhiko Kanda, Kentarou Asahi, Hiroyuki Tobinaga, Naomi Tamura, Yukio Tada, Naoko Kurihara, Miho Oohara, Shinji Shimada, Shigenori Yagi, Shunji Shinohara, Masayoshi Ogawa, Shoichi Yamamoto, Tohru Horiguchi, Hiroyuki Kai, Kouki Fuchino, Yukio Takahara, Emiko Taniguchi, Takayuki Kameyama, Sae Jikihara
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(5)
Some P2X3 receptor antagonists have been developed as new therapeutic drugs for pain. We discovered a novel chemotype of P2X3 receptor antagonists with a pyrrolinone skeleton. Because of SAR studies to improve bioavailability of lead compound 2, comp
Autor:
Nobuyoshi Hasebe, Hiroyuki Kai, Kosuke Anan, Shigenori Yagi, Shunji Shinohara, Shinji Shimada, Miho Ohara, Moriyasu Masui, Masaharu Kume, Hiroki Tsuji, Shoichi Yamamoto, Shin-Ichiro Hara
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(17)
NR2B subunit containing N-methyl-d-aspartate (NMDA) receptor is an attractive target for chronic pain due to its involvement in disease states and its limited distribution in the central nervous system. Cyclohexanol-based leads 6a and 6c were identif
Publikováno v:
Knee Surgery, Sports Traumatology, Arthroscopy. 21:556-563
Medial tibial stress syndrome (MTSS) and tibial stress fracture (SF) are common lower leg disorders in runners. A prospective study was done to identify the incidence of MTSS and SF in high school runners and to determine risk factors.A total of 230