Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Shigenori Ohkawa"'
Autor:
Osamu Uchikawa, Toru Yamano, Kiyoharu Matsumoto, Mari Adachi, Kohji Fukatsu, Shigenori Ohkawa, Masayuki Yamashita, Mitsutaka Tanaka, Mitsuru Kawada
Publikováno v:
Tetrahedron: Asymmetry. 17:184-190
Asymmetric synthesis of a novel non-benzodiazepine hypnotic drug Ramelteon (TAK-375) was accomplished via asymmetric hydrogenation. Development of the substrate design revealed that a novel class of substrate, allylic acylamine 4a, was hydrogenated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a53d76d45e175c552445df77c641fd
https://doi.org/10.1016/j.tetasy.2005.11.005
https://doi.org/10.1016/j.tetasy.2005.11.005
Autor:
Hisao Nishikawa, Keisuke Hirai, Hiroyuki Ohta, Yuu Fujiwara, Masaomi Miyamoto, Muneto Kita, Shigenori Ohkawa
Publikováno v:
Journal of Biological Rhythms. 20:27-37
In vivo pharmacological effects of ramelteon (TAK-375), a novel, highly MT1/MT2-selective receptor agonist, were studied in rats to determine ramelteon’s ability to reentrain the circadian rhythm after an abrupt phase advance. Experiments were also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708eeecedd0032cf2b3ac49abc62e478
https://doi.org/10.1177/0748730404269890
https://doi.org/10.1177/0748730404269890
Autor:
Yuji Kawamata, Kohji Fukatsu, Shigenori Ohkawa, Masaomi Miyamoto, Keisuke Hirai, Keiji Nishiyama, Shuji Hinuma, Koki Kato, Osamu Uchikawa
Publikováno v:
Neuropharmacology. 48:301-310
Ramelteon (TAK-375) is a novel melatonin receptor agonist currently under investigation for the treatment of insomnia. This study describes the neurochemical and receptor binding characteristics of ramelteon in vitro. Ramelteon showed very high affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147bc1ead753e424f18d398a06a7df1c
https://doi.org/10.1016/j.neuropharm.2004.09.007
https://doi.org/10.1016/j.neuropharm.2004.09.007
Autor:
Koki Kato, Mitsuru Kawada, Masaomi Miyamoto, Keisuke Hirai, Masayuki Yamashita, Toru Yamano, Osamu Uchikawa, Kohji Fukatsu, Shigenori Ohkawa, Shuji Hinuma
Publikováno v:
Journal of Medicinal Chemistry. 45:4212-4221
We synthesized a novel series of benzocycloalkene derivatives and evaluated their binding affinities to melatonin receptors. To control the spatial position of the amide group, one of the important pharmacophores, we incorporated an endo double bond,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babf6ea6c72e72cab52ab7ccf15a3475
https://doi.org/10.1021/jm020114g
https://doi.org/10.1021/jm020114g
Autor:
Shigenori Ohkawa, Takeshi Sakane, Osamu Uchikawa, Mitsuru Kawada, Yoichi Nagano, Naoki Tarui, Kiyoharu Matsumoto, Kazuo Nakahama
Publikováno v:
Journal of Bioscience and Bioengineering. 93:44-47
The chiral indan derivative (S)-2 (2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl-amine) was synthesized by enzyme-catalyzed asymmetric hydrolysis of the racemic acetamide 1 (N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddd428ec30181ca0421895217e0e968
https://doi.org/10.1016/s1389-1723(02)80052-4
https://doi.org/10.1016/s1389-1723(02)80052-4
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:784-792
TAK-218 has a 2,3-dihydrobenzofuran-5-amine (coumaran) structure which resembles alpha-tocopherol, and is a promising candidate as an agent for central nervous system (CNS) trauma and ischemia. The radical scavenging activity of TAK-218 was studied u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ce72b48f8cfd24939628667e836115
https://doi.org/10.1248/cpb.48.784
https://doi.org/10.1248/cpb.48.784
Publikováno v:
Tetrahedron: Asymmetry. 10:1521-1526
We performed an asymmetric synthesis of ( S )-2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-5-benzofuranamine dihydrochloride (TAK-218, 1 ), a compound used for the treatment of traumatic and ischemic central nervous system injur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e263a991fc93dfdd25d150ee30e367d7
https://doi.org/10.1016/s0957-4166(99)00138-x
https://doi.org/10.1016/s0957-4166(99)00138-x
Autor:
Shigenori Ohkawa, Philip S. Portoghese
Publikováno v:
Journal of Medicinal Chemistry. 41:4177-4180
A series of 7-arylidinenaltrexones (2a-m) related to the prototypical delta1-selective antagonist, 7-benzylidenenaltrexone 1 (BNTX), have been synthesized in an effort to develop more selective ligands. Testing in smooth muscle preparations revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8173b126e30c21d3fbffd84d7edab9dc
https://doi.org/10.1021/jm980384s
https://doi.org/10.1021/jm980384s
7-Spiroindanyl Derivatives of Naltrexone and Oxymorphone as Selective Ligands for δ Opioid Receptors
Publikováno v:
Journal of Medicinal Chemistry. 40:1720-1725
A series consisting of spiroindanyl (5-7), benzospiroindanyl (8-10), and spiroperinaphthyl (11) derivatives of naltrexone and oxymorphone were synthesized in order to investigate the role of an orthogonal-oriented "address" for delta opioid receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc54298c6a1a995e4e203e116ea5e61a
https://doi.org/10.1021/jm9700880
https://doi.org/10.1021/jm9700880
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 66:464-466
Racemic indan derivatives have been resolved by the hydrolysis of amide bonds using Corynebacterium ammoniagenes IFO12612 to produce (S)-amine and (R)-amides. In the kinetic resolution of 1 (N-[2-(6-methoxy-indan-1-yl)ethyl]acetamide), it was possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b10a7d9c75ea4b56bba67fdde1a3895
https://doi.org/10.1271/bbb.66.464
https://doi.org/10.1271/bbb.66.464