Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Shigenobu Okuda"'
Autor:
Shigeo Iwasaki, Akihiko Kawaguchi, Rumiko Shimazawa, Shigenobu Okuda, Hiroshi Funabashi, Naoko Morisaki, Jun Furukawa
Publikováno v:
European Journal of Biochemistry. 211:111-115
Yeast fatty-acid synthase (FAS) inhibition by cerulenin analogs with varying side-chain lengths was compared with that of cerulenin, tetrahydrocerulenin and iodoacetamide. Although inhibition by cerulenin was the highest, the analogs having (E,E)-del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cefbb5336bb484f7081cc937b42709a
https://doi.org/10.1111/j.1432-1033.1993.tb19876.x
https://doi.org/10.1111/j.1432-1033.1993.tb19876.x
Autor:
Jun Furukawa, Naoko Morisaki, T. Ando, Shigeo Iwasaki, Rumiko Shimazawa, Hiroshi Funabashi, Shigenobu Okuda, A. Kanematsu
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c386b5e7089492155ecb1ebc52e31694
https://doi.org/10.1002/chin.199340303
https://doi.org/10.1002/chin.199340303
Publikováno v:
The Journal of Organic Chemistry. 57:1271-1274
The biosynthetic origin of purpactin A (1) was studied by feeding sodium [1- 13 C]-, [2- 13 C]-, and [1,2- 13 C 2 ]acetates, DL-[2- 13 C]mevalonolactone, and L-[methyl- 13 C]methionine to the producing organism Penicillium purpurogenum FO-608. 13 C N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5fc6d4363d9b013b3f2db28617589bf
https://doi.org/10.1021/jo00030a040
https://doi.org/10.1021/jo00030a040
Autor:
Shigenobu Okuda, Rumiko Shimazawa, Naoko Morisaki, Akira Kanematsu, Hiroshi Funabashi, Jun Furukawa, Toshiaki Ando, Shigeo Iwasaki
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:2945-2953
Optically active cerulenin 1, a potent inhibitor of fatty acid synthetase, was prepared via the condensation of the epoxy aldehyde 8 and the alkenyl lithium 16. In order to evaluate the effects of (E, E)-1, 4-double bounds of the cerulenin side chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7293aded8950b16cf49ce22a5fdba11
https://doi.org/10.1248/cpb.40.2945
https://doi.org/10.1248/cpb.40.2945
Publikováno v:
The Journal of Antibiotics. 44:136-143
Penicillium purpurogenum FO-608, a soil isolate, was found to produce a series of new inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). Three active compounds, designated purpactins, A, B and C, were isolated from the fermentation broth of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661627108973a4ca62903997b0d223d8
https://doi.org/10.7164/antibiotics.44.136
https://doi.org/10.7164/antibiotics.44.136
Autor:
Satoshi Omura, Ryuichi Nagao, Hiroshi Tomoda, Shigenobu Okuda, Keizo Inoue, Jin Caoa, Xin-Hui Huang, Haruo Tanaka, Hiroyuki Arai, Hiroyuki Nishida
Publikováno v:
The Journal of antibiotics. 45(10)
The effect was studied of the fungal cyclodepsipeptide antibiotics beauvericin and seven distinct enniatins on acyl-CoA: cholesterol acyltransferase (ACAT) activity. In an enzyme assay using rat liver microsomes, all the compounds were found to inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1c43ac80fcebbed520d4140cf84005
https://pubmed.ncbi.nlm.nih.gov/1473990
https://pubmed.ncbi.nlm.nih.gov/1473990
Autor:
Shigenobu Okuda, Yoshitake Tanaka
Publikováno v:
The Search for Bioactive Compounds from Microorganisms ISBN: 9781461287612
For decades, pesticides have been utilized as crop protectants. They are useful for reduction of the harmful actions of field pests so as to increase crop yield and crop quality. The need for safe and excellent pesticides is more serious today than b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77df8687ee605afd41c93a25eb999ced
https://doi.org/10.1007/978-1-4612-4412-7_13
https://doi.org/10.1007/978-1-4612-4412-7_13
Autor:
Yoshitake Tanaka, Shigenobu Okuda
Publikováno v:
The Search for Bioactive Compounds from Microorganisms ISBN: 9781461287612
Fungal and bacterial infections in agriculture are found worldwide on about 1200 kinds of crop plants, fruit trees, and vegetables. Decreases in crop yields caused by microbial diseases are estimated to reach 9% – 10% each in rice, wheat, and corn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5338e4bbc408fe6706a5c229aee8c957
https://doi.org/10.1007/978-1-4612-4412-7_11
https://doi.org/10.1007/978-1-4612-4412-7_11
Autor:
Shigenobu Okuda
Publikováno v:
The Search for Bioactive Compounds from Microorganisms ISBN: 9781461287612
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c65b7fb5141780188c7196d93d06bac0
https://doi.org/10.1007/978-1-4612-4412-7_12
https://doi.org/10.1007/978-1-4612-4412-7_12
Publikováno v:
The Journal of antibiotics. 44(2)
The structure of purpactins, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses. Purpactin A was deduced to be 3-1'-acetoxy-11-hydroxy-4-methoxy-9-methyl-3'-methylbutyl-5H, 7H-dibenzo[b,g]-1,5-dioxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d205c4756ad1c390e182132dca5d8a
https://pubmed.ncbi.nlm.nih.gov/2010354
https://pubmed.ncbi.nlm.nih.gov/2010354