Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Shigenobu Kishino"'
Autor:
Azusa Saika, Takahiro Nagatake, Shigenobu Kishino, Nahoko Kitamura, Tetsuya Honda, Koji Hosomi, Prabha Tiwari, Eri Node, Soichiro Kawai, Saki Kondo, Kei Ishida, Kenji Kabashima, Jun Ogawa, Jun Kunisawa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Intestinal bacteria metabolize dietary substances to produce bioactive postbiotics, among which some are recognized for their role in promoting host health. We here explored the postbiotic potential of two omega-3 α-linolenic acid–derived metaboli
Externí odkaz:
https://doaj.org/article/022a996b610841cea714f99a2292266c
Autor:
Miki Ando, Kazuki Nagata, Ryuki Takeshita, Naoto Ito, Sakura Noguchi, Natsuki Minamikawa, Naoki Kodama, Asuka Yamamoto, Takuya Yashiro, Masakazu Hachisu, Gaku Ichihara, Shigenobu Kishino, Masayuki Yamamoto, Jun Ogawa, Chiharu Nishiyama
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Various gut bacteria, including Lactobacillus plantarum, possess several enzymes that produce hydroxy fatty acids (FAs), oxo FAs, conjugated FAs, and partially saturated FAs from polyunsaturated FAs as secondary metabolites. Among these derivatives,
Externí odkaz:
https://doaj.org/article/0e40a4ee1a6a4500ab7dfe998f90a64d
Autor:
Nanaho Kasahara, Yukiko Imi, Reina Amano, Masakazu Shinohara, Kumiko Okada, Yusei Hosokawa, Makoto Imamori, Chiaki Tomimoto, Jun Kunisawa, Shigenobu Kishino, Jun Ogawa, Wataru Ogawa, Tetsuya Hosooka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The antidiabetic drug pioglitazone ameliorates insulin resistance by activating the transcription factor PPARγ. In addition to its blood glucose–lowering action, pioglitazone exerts pleiotropic effects including amelioration of nonalcohol
Externí odkaz:
https://doaj.org/article/2c4335dd8e044a929c350cef77d4879a
Autor:
Hiroko Watanabe, Riku Usami, Shigenobu Kishino, Kengo Osada, Yudai Aoki, Hironobu Morisaka, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Wataru Aoki, Hiroyuki Suganuma, Jun Ogawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Cruciferous vegetables are rich sources of glucosinolates (GSLs). GSLs are degraded into isothiocyanates, which are potent anticarcinogens, by human gut bacteria. However, the mechanisms and enzymes involved in gut bacteria-mediated GSL meta
Externí odkaz:
https://doaj.org/article/7ef0c79422fa4eb7aa11e7d80a21fd2e
Autor:
Yu Fujita, Kuniyuki Kano, Shigenobu Kishino, Toshihiro Nagao, Xuefeng Shen, Chiharu Sato, Hatsune Hatakeyama, Yume Ota, Sho Niibori, Ayako Nomura, Kota Kikuchi, Wataru Yasuno, Sho Takatori, Kazunori Kikuchi, Yoshitake Sano, Taisuke Tomita, Toshiharu Suzuki, Junken Aoki, Kun Zou, Shunji Natori, Hiroto Komano
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA). The predominant dietary CLA is cis-9, trans-11-CLA (c-9, t-11-CLA), which constitutes up to ~ 90% of total CLA and is thought to be responsible for the positive health benefi
Externí odkaz:
https://doaj.org/article/fb153ff6b32e481daa74b997a95644a6
Autor:
Azusa Saika, Takahiro Nagatake, Shigenobu Kishino, Si‐Bum Park, Tetsuya Honda, Naomi Matsumoto, Michiko Shimojou, Sakiko Morimoto, Prabha Tiwari, Eri Node, So‐ichiro Hirata, Koji Hosomi, Kenji Kabashima, Jun Ogawa, Jun Kunisawa
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 1, Pp 59-71 (2020)
Abstract Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18‐epoxyeicosatetraenoic acid (17,18‐EpETE) as a lipid metabolite endoge
Externí odkaz:
https://doaj.org/article/4e11a89c773a4e4daef81db04045be1d
Autor:
Yuki Murata, Norio Harada, Shigenobu Kishino, Kanako Iwasaki, Eri Ikeguchi-Ogura, Shunsuke Yamane, Tomoko Kato, Yoshinori Kanemaru, Akiko Sankoda, Tomonobu Hatoko, Sakura Kiyobayashi, Jun Ogawa, Akira Hirasawa, Nobuya Inagaki
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102963- (2021)
Summary: Long-chain triglycerides (LCTs) intake strongly stimulates GIP secretion from enteroendocrine K cells and induces obesity and insulin resistance partly due to GIP hypersecretion. In this study, we found that medium-chain triglycerides (MCTs)
Externí odkaz:
https://doaj.org/article/2164c584dab04609a57a748fcf6b2b5e
Autor:
Junki Miyamoto, Miki Igarashi, Keita Watanabe, Shin-ichiro Karaki, Hiromi Mukouyama, Shigenobu Kishino, Xuan Li, Atsuhiko Ichimura, Junichiro Irie, Yukihiko Sugimoto, Tetsuya Mizutani, Tatsuya Sugawara, Takashi Miki, Jun Ogawa, Daniel J. Drucker, Makoto Arita, Hiroshi Itoh, Ikuo Kimura
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The gut microbiome is an important regulator of metabolic health. Here the authors show that intestinal bacteria metabolize dietary linoleic acid to 10-hydroxy-cis-12-octadecenoic acid (HYA) which confers host resistance to high fat diet-induced obes
Externí odkaz:
https://doaj.org/article/02b641191e8447a5869df691887199f7
Autor:
Shiori Ikeguchi, Yasuhiko Izumi, Nahoko Kitamura, Shigenobu Kishino, Jun Ogawa, Akinori Akaike, Toshiaki Kume
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 1, Pp 9-15 (2018)
10-oxo-trans-11-octadecenoic acid (KetoC) and 10-hydroxy-cis-12-octadecenoic acid (HYA) are long-chain fatty acids generated from linoleic acid by the gut lactic acid bacterium Lactobacillus plantarum. These fatty acids have been reported to have ant
Externí odkaz:
https://doaj.org/article/2e0b48e27885473496505d614d883a1f
Autor:
Ayumi Tanimura, Takashi Sugita, Rikiya Endoh, Moriya Ohkuma, Shigenobu Kishino, Jun Ogawa, Jun Shima, Masako Takashima
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202164 (2018)
The yeast strains IPM32-16, ISM28-8sT, and IPM46-17, isolated from plant and soil samples from Iriomote Island, Japan, were explored in terms of lipid production during growth in a mixture of glucose and xylose. Phylogenetically, the strains were mos
Externí odkaz:
https://doaj.org/article/8228b93fc0704aacbd99161fdd7db42e