Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shigenobu Hagino"'
Autor:
Hajime Kojima, Tokio Nakada, Akiko Yagami, Hiroaki Todo, Jihei Nishimura, Mio Yagi, Keiko Yamamoto, Mariko Sugiyama, Yoshiaki Ikarashi, Hitoshi Sakaguchi, Masahiko Yamaguchi, Morihiko Hirota, Sakiko Aizawa, Shota Nakagawa, Shigenobu Hagino, Masato Hatao
Publikováno v:
Current Research in Toxicology, Vol 4, Iss , Pp 100100- (2023)
Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evi
Externí odkaz:
https://doaj.org/article/87dee5b26ae9496ab51c2bcc9ad2ae5d
Autor:
Daiki Kyotani, Hidenobu Okumura, Shigeyuki Nomura, Takashi Omori, Yuki Handa, Yuko Okamoto, Yasuo Ohno, Noriyasu Imai, Hiroaki Todo, Setsuko Jitsukawa, Masakazu Katoh, Hidefumi Ikeda, Kenji Sugibayashi, Shigenobu Hagino, Miyuki Fujishiro, Nathalie Alépée, Akemi Toyoda, Mariko Sugiyama, Masaharu Akita, Koji Kurihara
Publikováno v:
Journal of Toxicological Sciences. 43(12):751-768
The Organisation for Economic Co-operation and Development (OECD) Test Guideline (TG) 439 is an in vitro test method of reconstructed human epidermis (RhE), which was developed for hazard identification of irritating chemicals in accordance with a pr
Publikováno v:
Scopus-Elsevier
A tier evaluation system for the identification of cosmetic ingredients that are not ocular irritants was applied to 59 cosmetic ingredients, for which in vivo data were available. The tier system employs monolayer cultures of SIRC cells, an establis
Publikováno v:
Toxicology in Vitro. 23:911-918
In this study, with the aim of developing a cell-based in vitro photosensitization assay, we examined whether changes of CD86 and CD54 expression on cells of a human monocytic cell line, THP-1, could be used to assess the photosensitizing potential o
Publikováno v:
Toxicology in Vitro. 23:687-696
In order to find a novel biomarker for a simple assay to predict skin sensitization, we evaluated cell-surface thiols as a biomarker reflecting intracellular signaling in THP-1 cells (human monocytic cell line). First, we found that a decrease of cel
Publikováno v:
Scopus-Elsevier
A tier evaluation system was assessed as an alternative method for the identification of cosmetic ingredients which are not ocular irritants. The system employed monolayer cultures of SIRC cells, an established cell line originally derived from the r
Autor:
Okihiko Sakamoto, Motoji Takahashi, Yoshiyuki Kohno, Masaaki Mori, Tetsuji Nakamura, Shigenobu Hagino
Publikováno v:
Journal of Society of Cosmetic Chemists of Japan. 27:33-40
The peroxidation of human skin surface lipids was investigated by a CL-HPLC (chemiluminescence-high performance liquid chromatography) system. Squalene mono-hydroperoxide was produced at the forehead and the scalp as well as in the dandruff under dai
Autor:
Akira Motoyama, Hitoshi Sasa, Mie Suzuki, Setsuya Aiba, Shigenobu Hagino, Hiroshi Itagaki, Morihiko Hirota, Masato Kitagaki, Masashi Yanagi, Hirokazu Kouzuki, Saori Kagatani
Publikováno v:
The Journal of toxicological sciences. 35(6)
Changes of cell-surface thiols induced by chemical treatment may affect the conformations of membrane proteins and intracellular signaling mechanisms. In our previous study, we found that a non-toxic dose of diphenylcyclopropene (DPCP), which is a po
Autor:
Setsuya Aiba, Saori Kagatani, Mie Suzuki, Yoshinori Sasaki, Shigenobu Hagino, Morihiko Hirota, Hiroshi Itagaki
Publikováno v:
The Journal of toxicological sciences. 34(2)
Human monocytic cell line THP-1 cells are used as an indicator for in vitro skin sensitization testing. Although p38 mitogen-activated protein kinases (MAPKs) and intracellular redox imbalance play crucial roles in the activation of THP-1 by skin sen
Publikováno v:
Scopus-Elsevier
The chorioallantoic membrane (CAM) test using fertile hen's eggs has been reported as a promising alternative method to predict the eye irritancy of chemicals. However, the scoring system of the original CAM test is not satisfactory because of its la