Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Shigemoto Fujii"'
Autor:
Takaaki Akaike, Tomoaki Ida, Fan-Yan Wei, Motohiro Nishida, Yoshito Kumagai, Md. Morshedul Alam, Hideshi Ihara, Tomohiro Sawa, Tetsuro Matsunaga, Shingo Kasamatsu, Akiyuki Nishimura, Masanobu Morita, Kazuhito Tomizawa, Akira Nishimura, Satoshi Watanabe, Kenji Inaba, Hiroshi Shima, Nobuhiro Tanuma, Minkyung Jung, Shigemoto Fujii, Yasuo Watanabe, Masaki Ohmuraya, Péter Nagy, Martin Feelisch, Jon M. Fukuto, Hozumi Motohashi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial
Externí odkaz:
https://doaj.org/article/59355d393d744dc18b1812f57d180eae
Autor:
Hisyam Abdul Hamid, Akira Tanaka, Tomoaki Ida, Akira Nishimura, Tetsuro Matsunaga, Shigemoto Fujii, Masanobu Morita, Tomohiro Sawa, Jon M. Fukuto, Péter Nagy, Ryouhei Tsutsumi, Hozumi Motohashi, Hideshi Ihara, Takaaki Akaike
Publikováno v:
Redox Biology, Vol 21, Iss , Pp - (2019)
The physiological importance of reactive sulfur species (RSS) such as cysteine hydropersulfide (CysSSH) has been increasingly recognized in recent years. We have established a reactive sulfur metabolomics analysis by using RSS metabolic profiling, wh
Externí odkaz:
https://doaj.org/article/1b2dc593936b4f80bbebc2b8ff87d3c1
Autor:
Daichi Chikazu, Koutaro Maki, Takaaki Akaike, Eri Izumida, Risa Uyama, Ryutaro Kamijo, Shigemoto Fujii, Kentaro Yoshimura, Kiyohito Sasa, Kazuhiro Nagayama, Yoichi Miyamoto, Kotaro Kaneko
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 55:45-51
Osteocytes regulate bone remodeling, especially in response to mechanical loading and unloading of bone, with nitric oxide reported to play an important role in that process. In the present study, we found that 8-nitroguanosine 3′,5′-cyclic monop
Publikováno v:
British Journal of Pharmacology. 176:607-615
Cysteine persulfide and polysulfide are produced in cells and exist in abundance in both low MW and protein fractions. However, the mechanism of regulation of the formation of cellular cysteine polysulfides and the physiological functions of cysteine
Autor:
Shigemoto Fujii, Takaaki Akaike, Yosuke Ikumi, Hiroki Saito, Shuhei Tanaka, Akiyo Ito, Hiroaki Shimokawa, Tomoaki Ida, Saori Sato, Shigeo Godo
Publikováno v:
Journal of Cardiovascular Pharmacology. 71:113-126
Aims Nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in maintaining cardiovascular homeostasis. We have previously demonstrated that endothelial NO synthase (eNOS) plays diverse roles depending on vessel size,
Autor:
R. Tsukuura, Yoichi Miyamoto, Shigemoto Fujii, Ryutaro Kamijo, Koutaro Maki, Marie Hoshino, Kazuhiro Nagayama, Takaaki Akaike, Kentaro Yoshimura, Daichi Chikazu, S. Inoue, Kiyohito Sasa, Kotaro Kaneko, Kazuyoshi Baba
Publikováno v:
Nitric Oxide. 72:46-51
Osteoclasts are multinucleated giant cells differentiated from monocyte-macrophage-lineage cells under stimulation of receptor activator of nuclear factor κ-B (RANK) ligand (RANKL) produced by osteoblasts and osteocytes. Although it has been reporte
Autor:
Masaki Ohmuraya, Jon M. Fukuto, Satoshi Watanabe, Nobuhiro Tanuma, Shingo Kasamatsu, Yasuo Watanabe, Motohiro Nishida, Tomoaki Ida, Hideshi Ihara, Takaaki Akaike, Akira Nishimura, Martin Feelisch, Hozumi Motohashi, Yoshito Kumagai, Péter Nagy, Kenji Inaba, Shigemoto Fujii, Kazuhito Tomizawa, Minkyung Jung, Akiyuki Nishimura, Tetsuro Matsunaga, Md. Morshedul Alam, Fan Yan Wei, Masanobu Morita, Tomohiro Sawa, Hiroshi Shima
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Cysteine hydropersulfide (CysSSH) occurs in abundant quantities in various organisms, yet little is known about its biosynthesis and physiological functions. Extensive persulfide formation is apparent in cysteine-containing proteins in Escherichia co
Autor:
Akira Tanaka, Masanobu Morita, Péter Nagy, Jon M. Fukuto, Hisyam Abdul Hamid, Akira Nishimura, Hozumi Motohashi, Ryouhei Tsutsumi, Shigemoto Fujii, Takaaki Akaike, Tomoaki Ida, Tomohiro Sawa, Tetsuro Matsunaga, Hideshi Ihara
Publikováno v:
Redox Biology
Redox Biology, Vol 21, Iss, Pp-(2019)
Redox Biology, Vol 21, Iss, Pp-(2019)
The physiological importance of reactive sulfur species (RSS) such as cysteine hydropersulfide (CysSSH) has been increasingly recognized in recent years. We have established a reactive sulfur metabolomics analysis by using RSS metabolic profiling, wh
Autor:
Katsuhiko Ono, Mizanur Rahaman, Shigemoto Fujii, Hiroyasu Tsutsuki, Philip Eaton, Tomohiro Sawa, Oleksandra Prysyazhna, Takaaki Akaike, Yuichi Oike, Khandaker Ahtesham Ahmed, Soichiro Akashi, Eiji Horio, Joseph R. Burgoyne, Tomoaki Ida
Publikováno v:
Biochemistry. 55:751-761
8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) is a nitrated derivative of guanosine 3',5'-cyclic monophosphate (cGMP) formed endogenously under conditions associated with production of both reactive oxygen species and nitric oxide. It ac
Autor:
Hozumi Motohashi, Shigemoto Fujii, Hideshi Ihara, Motohiro Nishida, Yoshito Kumagai, Takaaki Akaike
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
Redox signaling is a key modulator of oxidative stress induced by nonspecific insults of biological molecules generated by reactive oxygen species. Current redox biology is revisiting the traditional concept of oxidative stress, such that toxic effec