Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Shigeki Watanabe"'
Autor:
Zhenyong Wu, Grant F Kusick, Manon MM Berns, Sumana Raychaudhuri, Kie Itoh, Alexander M Walter, Edwin R Chapman, Shigeki Watanabe
Publikováno v:
eLife, Vol 12 (2024)
Despite decades of intense study, the molecular basis of asynchronous neurotransmitter release remains enigmatic. Synaptotagmin (syt) 7 and Doc2 have both been proposed as Ca2+ sensors that trigger this mode of exocytosis, but conflicting findings ha
Externí odkaz:
https://doaj.org/article/a941dafebeac4bb681369387d5e79f94
Autor:
Tyler H. Ogunmowo, Haoyuan Jing, Sumana Raychaudhuri, Grant F. Kusick, Yuuta Imoto, Shuo Li, Kie Itoh, Ye Ma, Haani Jafri, Matthew B. Dalva, Edwin R. Chapman, Taekjip Ha, Shigeki Watanabe, Jian Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Compensatory endocytosis keeps the membrane surface area of secretory cells constant following exocytosis. At chemical synapses, clathrin-independent ultrafast endocytosis maintains such homeostasis. This endocytic pathway is temporally and
Externí odkaz:
https://doaj.org/article/5cf401e46fe64d69884a9f4db7edc244
Autor:
Dennis Vettkötter, Martin Schneider, Brady D. Goulden, Holger Dill, Jana Liewald, Sandra Zeiler, Julia Guldan, Yilmaz Arda Ateş, Shigeki Watanabe, Alexander Gottschalk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Existing optogenetic silencing methods affect membrane potential, biochemistry or protein integrity. Here, the authors demonstrate an approach for silencing synaptic transmission that combines fast activation and reversibility, by using nondisruptive
Externí odkaz:
https://doaj.org/article/17a2ddfe2a2946ca86d655ad5e526bc7
Autor:
Satoshi Watanabe, Yuta Nihongaki, Kie Itoh, Toru Uyama, Satoshi Toda, Shigeki Watanabe, Takanari Inoue
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Approaches for manipulating individual organelles are important for learning more about their functions. Here the authors report a tool utilising phospholipase A/acyltransferases (PLAATs) for rapid defunctionalisation of organelles through remodellin
Externí odkaz:
https://doaj.org/article/fb70ab7254af4f4dabcd7ae96323f9d0
Autor:
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen
Publikováno v:
eLife, Vol 12 (2023)
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter. Presynaptic output is a function of the density of calcium channels, the dynami
Externí odkaz:
https://doaj.org/article/aff5d801f72a4f8aba271286f81e70b1
Autor:
Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi, Yoshito Tsushima, Noriko S. Ishioka
Publikováno v:
EJNMMI Physics, Vol 8, Iss 1, Pp 1-15 (2021)
Abstract Background We recently reported a new absorbed dose conversion method, RAP (RAtio of Pharmacokinetics), for 211At-meta-astatobenzylguanidine (211At-MABG) using a single biodistribution measurement, the percent injected dose/g. However, there
Externí odkaz:
https://doaj.org/article/8fb5e853cf504cbdb67b00c25c6997b4
Autor:
Ryujiro Hara, Naoki Goto, Daisuke Furuya, Toshihiko Kitahara, Hiroki Numata, Shigeki Watanabe, Hiroshi Kawada, Kiyoshi Ando
Publikováno v:
Case Reports in Oncology, Vol 14, Iss 3, Pp 1574-1579 (2021)
Haematopoietic insufficiency is the treatment target of lower-risk myelodysplastic syndrome (MDS). Although erythropoiesis-stimulating agents (ESAs) are generally effective for treating anaemia, resistance can develop. Hypoxia-inducible factor-prolyl
Externí odkaz:
https://doaj.org/article/c6b12a789d3d40dba5e269a5ed0a3177
Publikováno v:
Mechanical Engineering Journal, Vol 9, Iss 4, Pp 21-00397-21-00397 (2022)
For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, we have proposed the innovative “Liquid Bismuth Target System.” The target window in this system must be made from a material that resists the highly c
Externí odkaz:
https://doaj.org/article/1623a302f1ac4177a2e64ac1c939ab06
Autor:
Shuo Li, Sumana Raychaudhuri, Stephen Alexander Lee, Marisa M. Brockmann, Jing Wang, Grant Kusick, Christine Prater, Sarah Syed, Hanieh Falahati, Raul Ramos, Tomas M. Bartol, Eric Hosy, Shigeki Watanabe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Action potentials induce synchronous and asynchronous release of neurotransmitters. Here, the authors show that the synchronous and asynchronous release sites are aligned with AMPARs and NMDARs, respectively, in mouse hippocampal synapses. This organ
Externí odkaz:
https://doaj.org/article/eaa1dbfabc834db792c456f47bdb3077
Autor:
Jason D Vevea, Grant F Kusick, Kevin C Courtney, Erin Chen, Shigeki Watanabe, Edwin R Chapman
Publikováno v:
eLife, Vol 10 (2021)
Synaptotagmin 7 (SYT7) has emerged as a key regulator of presynaptic function, but its localization and precise role in the synaptic vesicle cycle remain the subject of debate. Here, we used iGluSnFR to optically interrogate glutamate release, at the
Externí odkaz:
https://doaj.org/article/17225c098b254268b655b5b6cafdb388