Výsledky vyhledávání - "Shigeki Shimasaki"

Akademický článek

Safety and Efficacy of the Sirolimus Gel for TSC Patients With Facial Skin Lesions in a Long-Term, Open-Label, Extension, Uncontrolled Clinical Trial

Autor: Mari Wataya-Kaneda, Hiroshi Nagai, Yuuki Ohno, Hiroo Yokozeki, Yasuyuki Fujita, Hironori Niizeki, Kazue Yoshida, Masaaki Ogai, Yuichi Yoshida, Akihiko Asahina, Kazuyoshi Fukai, Chiharu Tateishi, Izumi Hamada, Tatsuro Takahata, Kenji Shimizu, Shigeki Shimasaki, Hiroyuki Murota

Publikováno v: Dermatology and Therapy, Vol 10, Iss 4, Pp 635-650 (2020)

Abstract Introduction Our previous clinical studies have demonstrated the short-term efficacy and safety of the sirolimus gel for patients with tuberous sclerosis complex (TSC). However, long-term clinical evidence is lacking. Our objective was to as

Externí odkaz: https://doaj.org/article/71187a866eb04dbdad37e301feef95c2

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Safety and Efficacy of the Sirolimus Gel for TSC Patients With Facial Skin Lesions in a Long-Term, Open-Label, Extension, Uncontrolled Clinical Trial

Autor: Hironori Niizeki, Chiharu Tateishi, Kazuyoshi Fukai, Shigeki Shimasaki, Yasuyuki Fujita, Izumi Hamada, Tatsuro Takahata, Akihiko Asahina, Yuuki Ohno, Hiroyuki Murota, Hiroo Yokozeki, Masaaki Ogai, Kenji Shimizu, Mari Wataya-Kaneda, Yuichi Yoshida, Kazue Yoshida, Hiroshi Nagai

Publikováno v: Dermatology and Therapy, Vol 10, Iss 4, Pp 635-650 (2020)
Dermatology and Therapy

Introduction Our previous clinical studies have demonstrated the short-term efficacy and safety of the sirolimus gel for patients with tuberous sclerosis complex (TSC). However, long-term clinical evidence is lacking. Our objective was to assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa3201100311a69f505849693888027
https://doi.org/10.1007/s13555-020-00387-7

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Bioavailability of intravenous fosphenytoin sodium in healthy Japanese volunteers

Autor: Susumu Kobayashi, Tadayuki Hiroki, Naotaka Usui, Yushi Inoue, Kenji Shimizu, Shigeki Shimasaki

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics

To compare and evaluate the bioavailability for intravenous fosphenytoin sodium with that of intravenous phenytoin sodium in Japanese subjects. In study 1, healthy Japanese male volunteers received a 30-min infusion of 375 mg fosphenytoin sodium or a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e48e87cfead209096976867ad15bec
https://doi.org/10.1007/s13318-012-0105-x

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Population pharmacokinetics of phenytoin after intravenous administration of fosphenytoin sodium in pediatric patients, adult patients, and healthy volunteers

Autor: Shigeki Shimasaki, Kenji Shimizu, Yuji Kumagai, Hidefumi Kasai, Jun Tanaka

Publikováno v: European Journal of Clinical Pharmacology

Purpose We performed a population pharmacokinetic analysis of phenytoin after intravenous administration of fosphenytoin sodium in healthy, neurosurgical, and epileptic subjects, including pediatric patients, and determined the optimal dose and infus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277e8776749c8048a5c524710bab28b6

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