Výsledky vyhledávání - "Shigeki Shibasaki"

Active Uptake of Ulifloxacin from Plasma to Lung That Controls Its Concentration in Epithelial Lining Fluid

Autor: Makoto Aoki, Masahiro Hayashi, Hiroyuki Hayashi, Shigeki Shibasaki, Maki Iguchi, Tohru Kurosawa

Publikováno v: Biological & Pharmaceutical Bulletin. 32:1095-1100

Ulifloxacin is a new quinolone antibiotic and it is effective against pneumonia. We previously showed that it is highly distributed into the epithelial lining fluid (ELF) in rats, which might be resulting from certain active transport. The transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8eb4587a1ee53cb64c40c2b188211c
https://doi.org/10.1248/bpb.32.1095

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Population Pharmacokinetics of Tebipenem Pivoxil (ME1211), a Novel Oral Carbapenem Antibiotic, in Pediatric Patients with Otolaryngological Infection or Pneumonia

Autor: Hiroyuki Hayashi, Tohru Kurosawa, Shigeki Shibasaki, Kyoichi Totsuka, Nayu Mitomi, Jun Morita, Tomokazu Koresawa, Koji Kijima, Hisashi Suzuki, Nobuo Sato

Publikováno v: Drug Metabolism and Pharmacokinetics. 23:434-446

Tebipenem pivoxil (TBPM-PI, ME1211) has been under development as the world's first oral carbapenem for treatment of otolaryngological/respiratory infections caused by drug-resistant S. pneumoniae in pediatric patients. In order to treat these infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7167e629a8ef1c6f95f2a91f451959a9
https://doi.org/10.2133/dmpk.23.434

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Proposal of Membrane Transport Mechanism of Protein-Unbound Ulifloxacin into Epithelial Lining Fluid Determined by Improved Microdialysis

Autor: Hisashi Suzuki, Hiroyuki Hayashi, Shigeki Shibasaki, Maki Iguchi, Makoto Aoki, Tohru Kurosawa, Masahiro Hayashi

Publikováno v: Biological and Pharmaceutical Bulletin. 31:1773-1777

Microdialysis method (MD) is useful for sampling protein-unbound substances in vivo. Generally in the MD, a reference compound is used to correct differences in drug permeation clearance through a dialysis membrane in vivo and in vitro. No reference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75385e95c38b1ce411733ac075d938a6
https://doi.org/10.1248/bpb.31.1773

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ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output

Autor: Tohru Kurosawa, Shigeki Shibasaki, Kouichi Yoshinari, Masahiro Nomoto, Frank J. Gonzalez, Yasuhiro Shindo, Miki Shimada, Yasushi Yamazoe, Masaaki Miyata

Publikováno v: European Journal of Pharmacology. 574:192-200

ME3738 (22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol), a derivative of soyasapogenol, attenuates liver disease in several models of chronic liver inflammation. In the present study, we have investigated a protective effect of ME3738 in a typical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ead896fda2cda78f505e66060e5e5c
https://doi.org/10.1016/j.ejphar.2007.07.004

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Transporter-Mediated Hepatic Uptake of Ulifloxacin, an Active Metabolite of a Prodrug-Type New Quinolone Antibiotic Prulifloxacin, in Rats

Autor: Tohru Kurosawa, Yukihiro Yagi, Yukio Kato, Akira Tsuji, Shigeki Shibasaki, Makoto Aoki, Maki Iguchi

Publikováno v: Drug Metabolism and Pharmacokinetics. 22:350-357

Summary: Prulifloxacin (PUFX) is a prodrug-type new quinolone antibiotic and immediately converted to an active metabolite, ulifloxacin (UFX). It has been previously reported that UFX is highly excreted into the bile, although the hepatic uptake proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e127537b61593e353b8db41317d762de
https://doi.org/10.2133/dmpk.22.350

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Prediction of Cerebrospinal Fluid Concentrations of Quinolone Antibiotics in Humans Using Parameters for Penetration into Cerebrospinal Fluid of Animals

Autor: Shigeki Shibasaki, Izumi Komiya

Publikováno v: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 31:255-260

Cerebrospinal fluid (CSF) concentrations of quinolone antibiotics in humans, which may be related to CNS adverse effects and quinolone antibiotic-induced convulsions, were predicted from parameters for penetration into the CSF (CSF-to-unbound plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46864d7c0671064219749a1a6e20cb21
https://doi.org/10.5649/jjphcs.31.255

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Protective Effect of Inactive Ingredients against Nephrotoxicity of Vancomycin Hydrochloride in Rats

Autor: Shigeki Shibasaki, Yoshihisa Nakano, Nayu Mitomi, Akiko Gyobu, Naoko Hodoshima, Masaaki Izumi, Toru Kurosawa, Yukari Nakamura, Makoto Aoki

Publikováno v: Drug Metabolism and Pharmacokinetics. 19:68-75

A generic form of vancomycin for I.V. infusion (MEEK) is more soluble and stable than the brand-name form of vancomycin hydrochloride (VCM) due to the addition of two inactive ingredients: D-mannitol and Macrogol400 (PEG400). The aim of the present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93191c38e55d156510922c78aad6e5d
https://doi.org/10.2133/dmpk.19.68

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Population pharmacokinetics of cefditoren pivoxil in non-infected adults

Autor: Kayoko, Matsumoto, Nobuo, Sato, Nayu, Mitomi, Yoshihisa, Shitara, Shigeki, Shibasaki

Publikováno v: The Japanese journal of antibiotics. 67(1)

Population pharmacokinetic analysis was conducted on cefditoren pivoxil (CDTR-PI), a third generation oral antibiotic to evaluate the effect of covariates on pharmacokinetic parameters. Plasma concentrations of cefditoren (CDTR, total number of sampl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58e74640298efa6e1afb859b5d562378
https://pubmed.ncbi.nlm.nih.gov/24809208

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Prediction of clinical bacteriological efficacy of oral antibiotics using a mechanism-based pharmacokinetic-pharmacodynamics modeling

Autor: Kayoko, Matsumoto, Toshie, Sugano, Nobuo, Sato, Takashi, Ida, Shigeki, Shibasaki

Publikováno v: The Japanese journal of antibiotics. 67(1)

The objective of this study was to predict the clinical bacteriological efficacy of antibiotics and to examine the pharmacodynamics (PD) characteristics of antibiotics against bacterial strains using a mechanism-based pharmacokinetic-pharmacodynamics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04b28107cecfdbb93c067994685d071e
https://pubmed.ncbi.nlm.nih.gov/24809207

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