Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Shigeki Seto"'
Publikováno v:
Bioorganicmedicinal chemistry. 34
Bromodomain and extra-terminal domain (BET) protein plays an important role in epigenetic regulation, and the regulation of disruption contributes to the pathogenesis of cancer and inflammatory disease. With the goal of discovering novel BET inhibito
Autor:
Hiroyuki Watanabe, Yoshifumi Saito, Atsushi Kondo, Shigeki Seto, Yosuke Nishigaya, Nobuyuki Tanaka, Naohiro Kawamura, Yasushi Kohno, Kentaro Umei, Kazuya Tatani, Tatsuhiro Kondo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4044-4050
A scaffold-hopping strategy towards a new pyrazolo[1,5- a ]pyridine based core using molecular hybridization of two structurally distinct EP 1 antagonists, followed by structure-activity relationship-guided optimization, resulted in the identificatio
Autor:
Yasushi Kohno, Shigeki Seto, Kazuya Tatani, Kentaro Umei, Nobuyuki Tanaka, Yosuke Nishigaya, Atsushi Kondo
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2635-2642
Novel pyrazolo[1,5- a ]pyridine derivatives were designed, synthesized and evaluated as orally active EP 1 antagonists for the treatment of overactive bladder. Matched molecular pair analysis (MMPA) allowed the design of a new series of pyrazolo[1,5-
Publikováno v:
Tetrahedron. 72:1566-1572
PBr3-mediated reductive deoxygenation of α-aryl-pyridinemethanols to provide arylmethylpyridines is described, the alcohol substrate scope is explored, free radical trap TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) is introduced, and the hydrogen so
Publikováno v:
Synthesis. 47:3221-3230
Convenient access to a variety of 2-arylated pyrazolo[1,5-a]pyridine via pyrazolo[1,5-a]pyridine-2-yl triflate using the Suzuki–Miyaura cross-coupling reaction is described. Fifteen 2-arylpyrazolo[1,5-a]pyridine derivatives were synthesized i
Autor:
Yosuke, Nishigaya, Kentaro, Umei, Yoshifumi, Saito, Hiroyuki, Watanabe, Tatsuhiro, Kondo, Atsushi, Kondo, Naohiro, Kawamura, Kazuya, Tatani, Yasushi, Kohno, Nobuyuki, Tanaka, Shigeki, Seto
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(17)
A scaffold-hopping strategy towards a new pyrazolo[1,5-a]pyridine based core using molecular hybridization of two structurally distinct EP
Publikováno v:
Tetrahedron Letters. 55:5963-5966
We describe the straightforward synthesis of 6-substituted-2-aminopyrazolo[1,5-a]pyridines from 2-pyridineacetonitriles by N-amination with O-(mesitylsulfonyl)hydroxylamine and subsequent base-promoted cyclization. This N-amination/intramolecular cyc
Autor:
Kentaro, Umei, Yosuke, Nishigaya, Atsushi, Kondo, Kazuya, Tatani, Nobuyuki, Tanaka, Yasushi, Kohno, Shigeki, Seto
Publikováno v:
Bioorganicmedicinal chemistry. 25(9)
Novel pyrazolo[1,5-a]pyridine derivatives were designed, synthesized and evaluated as orally active EP
Publikováno v:
ChemInform. 47
PBr3-mediated reductive deoxygenation of α-aryl-pyridinemethanols to provide arylmethylpyridines is described, the alcohol substrate scope is explored, free radical trap TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) is introduced, and the hydrogen so
Publikováno v:
ChemInform. 47
The title pyridines are obtained by convenient reaction of pyridine triflates with various aryl boronic acids.