Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Shigeki Sasaki"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1274 (2021)
MTH1 is an enzyme that hydrolyzes 8-oxo-dGTP, which is an oxidatively damaged nucleobase, into 8-oxo-dGMP in nucleotide pools to prevent its mis-incorporation into genomic DNA. Selective and potent MTH1-binding molecules have potential as biological
Externí odkaz:
https://doaj.org/article/c3fc271743d344a09cbe3f5112637f4a
Publikováno v:
Molecules, Vol 20, Iss 1, Pp 1078-1087 (2015)
The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (
Externí odkaz:
https://doaj.org/article/75a687c4a78741f89d8f248f4afe923a
Autor:
Shigeki Sasaki
Publikováno v:
Ladder Polymers. :301-321
Publikováno v:
Chemical and Pharmaceutical Bulletin. 71:64-69
In nucleic acid drug discovery, it is extremely important to develop a technology to understand the distribution in target organs and to trace the degradation process in the body in order to optimize the structure and improve the efficiency of the cl
Publikováno v:
Chemical and Pharmaceutical Bulletin. 70:498-504
Due to the importance of the RNA chemical modifications, methods for the selective chemical modification at a predetermined site of the internal position of RNA have attracted much attention. We have developed functional artificial nucleic acids that
Publikováno v:
Current Medicinal Chemistry. 30
Abstract: Based on the sequence-specific recognition of target duplex DNA by triplex-forming oligonucleotides (TFOs) at the major groove side, the antigene strategy has been exploited as a gene-targeting tool with considerable attention. Triplex DNA
Autor:
Hirotaka, MURASE, Shigeki, SASAKI
Publikováno v:
長崎国際大学論叢 = Nagasaki International University Review. 22:177-185
遺伝子中に含まれるリピート配列は、ステムループ構造や G4 重鎖構造など様々な高次構造を形成することで、遺伝子発現を制御する重要な因子として働くことが知られている。しかし
Publikováno v:
RSC Medicinal Chemistry.
Antigene methods are a promising novel therapeutic approach to suppress abnormal gene expression. One of these methods inhibits transcription by forming triplex DNA against duplex DNA. However, by using natural-type...
Publikováno v:
Organic & Biomolecular Chemistry. 20:3375-3381
A small-molecular G-clamp ligand that converts the G-quadruplex of CGG repeats to a hairpin form has been developed.
Autor:
Ryo Miyahara, Takato Sakurada, Yoshiya Kikukawa, Yosuke Taniguchi, Yusuke Nagata, Shigeki Sasaki, Ryoji Kawazoe
Publikováno v:
Chemical and Pharmaceutical Bulletin. 69:1061-1066
γ-Amido-modified 2'-deoxynucleoside triphosphates (dNTPs) and nucleoside triphosphates (NTPs) are becoming increasingly important as biological tools. We herein describe the simple and easy synthesis of γ-amido-dNTPs and -NTPs from commercially ava