Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shigeki Omachi"'
Autor:
Natsumi Miyajima, Miwa Ito, Takemi Rokugawa, Hitoshi Iimori, Sotaro Momosaki, Shigeki Omachi, Eku Shimosegawa, Jun Hatazawa, Kohji Abe
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Background Translocator protein (TSPO) imaging can be used to detect neuroinflammation (including microglial activation) after acute cerebral infarction. However, longitudinal changes of TSPO binding after mild ischemia that induces selectiv
Externí odkaz:
https://doaj.org/article/4ef47e890e0e463595df2c7983cfa7f7
Autor:
Atsushi Nakamura, Hiroko Ono, Azusa Ando, Mikie Hinata, Kazuki Niidome, Shigeki Omachi, Gaku Sakaguchi, Shunji Shinohara
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 9-17 (2017)
We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC mo
Externí odkaz:
https://doaj.org/article/46245ec94f2840988654d3441227fa84
Autor:
Hiroto Miwa, Shigeki Omachi, Koji Takahashi, Kinichi Nakashima, Sosuke Yoneda, Bijay Parajuli, Miki Tanimura, Masahide Fujita, Hiroki Saito, Toshiyuki Asaki, Eiji Shigetomi, Schuichi Koizumi, Youichi Shinozaki
Publikováno v:
Glia. 69:2332-2348
Microglia are the resident immune cells of the brain, and play essential roles in neuronal development, homeostatic function, and neurodegenerative disease. Human microglia are relatively different from mouse microglia. However, most research on huma
Autor:
Ryuta Tamano, Minoru Hasegawa, Sosuke Yoneda, Masatomo Rokushima, Gaku Sakaguchi, Masahide Fujita, Erika Yogo, Toshiyuki Asaki, Shigeki Omachi, Shunji Shinohara
Publikováno v:
European Journal of Pharmacology. 833:263-274
Microglia exhibit various activation phenotypes in the spinal cord after peripheral nerve injury, and promote neuropathic pain. Ibudilast is a phosphodiesterase inhibitor with anti-inflammatory activity, but its effect on activated microglia in chron
Autor:
Eku Shimosegawa, Sotaro Momosaki, Kohji Abe, Takemi Rokugawa, Jun Hatazawa, Hitoshi Iimori, Miwa Ito, Natsumi Miyajima, Shigeki Omachi
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-12 (2018)
Background Translocator protein (TSPO) imaging can be used to detect neuroinflammation (including microglial activation) after acute cerebral infarction. However, longitudinal changes of TSPO binding after mild ischemia that induces selective neurona
Publikováno v:
PAIN RESEARCH. 29:161-170
Autor:
Hiroko Ono, Shigeki Omachi, Atsushi Nakamura, Azusa Ando, Kazuki Niidome, Mikie Hinata, Gaku Sakaguchi, Shunji Shinohara
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 9-17 (2017)
We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC mo
Autor:
Mika Kimura, Natsumi Imamoto, Shigeki Omachi, Sotaro Momosaki, Naoki Kanegawa, Kohji Abe, Shunji Shinohara, Hiroko Yamato, Masahide Fujita
Publikováno v:
NeuroImage. 79
The role of glial activation has been implicated in the development and persistence of neuropathic pain after nerve injury by recent studies. PK11195 binding to the translocator protein 18kDa (TSPO) has been shown to be enhanced in activated microgli
Autor:
Masatoshi Nakajima, R. Kawamori, Shiro Maeda, Tatsuhiko Tsunoda, Toru Yanagimoto, Yasuhiko Iwamoto, Shigeki Omachi, Masahito Imanishi, Yasushi Tanaka, Toshihiro Shinosaki, Akio Kanazawa, Susumu Saito, Tomohiro Iiizumi, Akihiro Sekine, Minoru Ikeda, Daisuke Koya, Koichi Kawai, Yoshihiro Kawamura, Masafumi Matsuda, Yusuke Nakamura, Kohei Kaku, Atsunori Kashiwagi, Ryuichi Kikkawa, Tetsuya Babazono, Atsuyuki Shimazaki
Publikováno v:
Diabetes. 54(4)
To search for a gene(s) conferring susceptibility to diabetic nephropathy (DN), we genotyped over 80,000 genebased single nucleotide polymorphisms (SNPs) in Japanese patients and identified that the engulfment and cell motility 1 gene (ELMO1) was a l
Autor:
Yo Kishi, Norio Nakatsuji, Makoto Ideguchi, Hideki Hayashi, Yoshiki Sasai, Shigeki Omachi, Asuka Morizane, Yo Okamoto, Takuya Hayashi, Masaomi Koyanagi, Hiroshi Kawasaki, Nobuyuki Itoh, Nobuo Hashimoto, Hidemoto Saiki, Takayuki Imazato, Hitoshi Fukuda, Jun Takahashi, Hidehiko Iida, Hirofumi Suemori, Yasushi Takagi
Publikováno v:
Scopus-Elsevier
Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic (DA) neurons. ES cells are currently the most promising donor cell source for cell-replacement therapy in PD. We previously described a strong neura