Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shigeki Nishitani"'
Autor:
Jihoon Shin, Shinichiro Toyoda, Yosuke Okuno, Reiko Hayashi, Shigeki Nishitani, Toshiharu Onodera, Haruyo Sakamoto, Shinya Ito, Sachiko Kobayashi, Hirofumi Nagao, Shunbun Kita, Michio Otsuki, Atsunori Fukuhara, Kazuhiro Nagata, Iichiro Shimomura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Adiposity varies among individuals with the influence of diverse physiological, pathological, environmental, hormonal, and genetic factors, but a unified molecular basis remains elusive. Here, we identify HSP47, a collagen-specific chaperone
Externí odkaz:
https://doaj.org/article/0b6269b282184cd7a12a5062591aad30
Autor:
Shigeki Nishitani, Atsunori Fukuhara, Issei Tomita, Shinji Kume, Jihoon Shin, Yosuke Okuno, Michio Otsuki, Hiroshi Maegawa, Iichiro Shimomura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Ketone bodies, including 3HBA, are endogenous products of fatty acid oxidation, and Hmgcs2 is the first rate-limiting enzyme of ketogenesis. From database analysis and in vivo and in vitro experiments, we found that adipose tissue and adipoc
Externí odkaz:
https://doaj.org/article/49d26bb603de4695bf8d37d093461642
Autor:
Jihoon Shin, Michio Otsuki, Atsunori Fukuhara, Shigeki Nishitani, Iichiro Shimomura, Shunbun Kita, Shinichiro Toyoda
Publikováno v:
Diabetes
Aging, obesity, and diabetes are major risk factors for the severe progression and outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]), but the underlying mechanism is not yet fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795f9980684af6fa133f40ef743159cf
http://europepmc.org/articles/PMC8660985
http://europepmc.org/articles/PMC8660985
Autor:
Jihoon Shin, Shinichiro Toyoda, Shigeki Nishitani, Toshiharu Onodera, Shiro Fukuda, Shunbun Kita, Atsunori Fukuhara, Iichiro Shimomura
Publikováno v:
Metabolism: clinical and experimental. 133
COVID-19 can cause multiple organ damages as well as metabolic abnormalities such as hyperglycemia, insulin resistance, and new onset of diabetes. The insulin/IGF signaling pathway plays an important role in regulating energy metabolism and cell surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47867cd7ac2ce2e3880e6ae27db431ad
https://pubmed.ncbi.nlm.nih.gov/35688210
https://pubmed.ncbi.nlm.nih.gov/35688210
Autor:
Kenta Okuro, Tomoaki Hayakawa, Michio Otsuki, Iichiro Shimomura, Shigeki Nishitani, Atsunori Fukuhara, Yosuke Okuno, Tomomi Minemura
Publikováno v:
Biochemical and biophysical research communications. 585
Glutamine is the most abundant amino acid in the body, and adipose tissue is one of the glutamine-producing organs. Glutamine has important and unique metabolic functions; however, its effects in adipocytes are still unclear. 3T3-L1 adipocytes produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf888a376524d22dc343f46a8685f22
https://pubmed.ncbi.nlm.nih.gov/34801935
https://pubmed.ncbi.nlm.nih.gov/34801935
Autor:
Iichiro Shimomura, Michio Otsuki, Shunbun Kita, Atsunori Fukuhara, Shigeki Nishitani, Shinichiro Toyoda, Jihoon Shin
Aging, obesity and diabetes are major risk factors for the severe progression and outcome of SARS-CoV-2 infection (COVID-19), but the underlying mechanism is not yet fully understood. In this study, we found that the SARS-CoV-2 spike protein physical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4b8a9adafad85c343763ccc73f6ed4
https://doi.org/10.2337/figshare.16700761
https://doi.org/10.2337/figshare.16700761
Autor:
Iichiro Shimomura, Michio Otsuki, Shigeki Nishitani, Hiroyuki Kawano, Atsunori Fukuhara, Yasutaka Jinno, Takashi Yano
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 128:548-555
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid with anti-inflammatory effects. To determine the effects of EPA on metabolic pathways in obese adipose tissues and liver, mice were fed normal chow diet (NCD), high-fat diet (HFD), or 3% EPA-contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86af4f0a66d53181dabf003664d2143
https://doi.org/10.1055/a-0802-9064
https://doi.org/10.1055/a-0802-9064
Autor:
Michio Otsuki, Shigeki Nishitani, Iichiro Shimomura, Atsunori Fukuhara, Yosuke Okuno, Jihoon Shin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Sodium/glucose cotransporter 2 (SGLT2) inhibitor improves systemic glucose metabolism. To clarify the effect of dapagliflozin, we performed gene expression microarray and metabolomic analyses of murine adipose tissue. Three groups of mice were used;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb629754a7c7c97cc64f5a327bac570b
http://link.springer.com/article/10.1038/s41598-018-27181-y
http://link.springer.com/article/10.1038/s41598-018-27181-y
Autor:
Hirokazu Uemura, Shigeki Nishitani, Ken-ichi Inakami, Takashi Fujii, Masamitsu Nagahara, Takeo Sato, Kunitoshi Yoshino
Publikováno v:
Nihon Kikan Shokudoka Gakkai Kaiho. 49:259-262
Cervical esophageal cancer is usually diagnosed at an advanced stage, and treatment is often limited to palliation. So it is difficult for the patients to benefit fully from treatments such as surgery, irradiation and chemotherapy. Surgery, which off
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ac5d145dad793c97debe2b00c93d5e
https://doi.org/10.2468/jbes.49.259
https://doi.org/10.2468/jbes.49.259
Autor:
Takashi Fujii, Shigeki Nishitani, Masamitsu Nagahara, Kunitoshi Yoshino, Ken-ichi Inakami, Yakeo Sato, Jun Okita
Publikováno v:
JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY. 7:123-132
A total of 225 patients with carcinoma of the hypopharynx and the cervical esophagus were treated surgically between 1986 and 1996 at Osaka Medical Center for Cancer and Cardiovascular Diseases. There were the following three types of defect resultin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eaff56ded48f14aaf29fa38b136425d
https://doi.org/10.5106/jjshns.7.123
https://doi.org/10.5106/jjshns.7.123