Výsledky vyhledávání - "Shigeki Mitsunaga"

Akademický článek

Detection of APP gene recombinant in human blood plasma

Autor: Shigeki Mitsunaga, Naoko Fujito, Hirofumi Nakaoka, Ryoko Imazeki, Eiichiro Nagata, Ituro Inoue

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)

Abstract The pathogenesis of Alzheimer’s disease (AD) is believed to involve the accumulation of amyloid-β in the brain, which is produced by the sequential cleavage of amyloid precursor protein (APP) by β-secretase and γ-secretase. Recently, an

Externí odkaz: https://doaj.org/article/4d1ad25c5d094766b037cf99d26682a6

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Possible association between dysfunction of vitamin D binding protein (GC Globulin) and migraine attacks.

Autor: Eiichiro Nagata, Natsuko Fujii, Kazuyoshi Hosomichi, Shigeki Mitsunaga, Yoichi Suzuki, Yoichi Mashimo, Hideo Tsukamoto, Tadayuki Satoh, Motoki Osawa, Ituro Inoue, Akira Hata, Shunya Takizawa

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105319 (2014)

To identify the genetic causality of migraine and acute, severe melalgia, we performed a linkage analysis and exome sequencing in a family with four affected individuals. We identified a variant (R21L) in exon 2 of the GC globulin gene, which is invo

Externí odkaz: https://doaj.org/article/f9f6bf6d7591473797c40863b7935963

Zobrazit plný text záznamu

Akademický článek

Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population.

Autor: Hirofumi Nakaoka, Shigeki Mitsunaga, Kazuyoshi Hosomichi, Liou Shyh-Yuh, Taiji Sawamoto, Tsutomu Fujiwara, Naohisa Tsutsui, Koji Suematsu, Akira Shinagawa, Hidetoshi Inoko, Ituro Inoue

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60793 (2013)

The polymorphisms in the human leukocyte antigen (HLA) region are powerful tool for studying human evolutionary processes. We investigated genetic structure of Japanese by using five-locus HLA genotypes (HLA-A, -B, -C, -DRB1, and -DPB1) of 2,005 indi

Externí odkaz: https://doaj.org/article/d7f8228b02f24ec9a80f4063b68b00b1

Zobrazit plný text záznamu

Akademický článek

A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.

Autor: Hirofumi Nakaoka, Tailin Cui, Atsushi Tajima, Akira Oka, Shigeki Mitsunaga, Koichi Kashiwase, Yasuhiko Homma, Shinji Sato, Yasuo Suzuki, Hidetoshi Inoko, Ituro Inoue

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25389 (2011)

Genome-wide association studies (GWAS) have yielded novel genetic loci underlying common diseases. We propose a systems genetics approach to utilize these discoveries for better understanding of the genetic architecture of rheumatoid arthritis (RA).

Externí odkaz: https://doaj.org/article/ac1201eef13e4dcdb61988a8f9bac734

Zobrazit plný text záznamu

Akademický článek

A Bead-based Normalization for Uniform Sequencing depth (BeNUS) protocol for multi-samples sequencing exemplified by HLA-B.

Autor: Kazuyoshi Hosomichi¹ (AUTHOR), Shigeki Mitsunaga² (AUTHOR), Hideki Nagasaki³ (AUTHOR), Ituro Inoue¹ (AUTHOR) itinoue@nig.ac.jp

Publikováno v: BMC Genomics. 2014, Vol. 15 Issue 1, p645-653. 9p. 1 Diagram, 1 Chart, 2 Graphs.

Zobrazit plný text záznamu

HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing

Autor: Masao Ota, Jerzy K. Kulski, Yuko Okudaira, Akira Oka, Eri Kikkawa, Shingo Suzuki, Takashi Shiina, Yuki Ozaki, Atsuko Shigenari, Shigeki Mitsunaga, Hidetoshi Inoko

Publikováno v: Tissue Antigens. 83:10-16

Super high-resolution single molecule sequence-based typing (SS-SBT) is a human leukocyte antigen (HLA) DNA typing method to the field 4 level of allelic resolution (formerly known as eight-digit typing) to efficiently detect new and null alleles wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::944d6f6c4890859c23eb3b92be57850c
https://doi.org/10.1111/tan.12258

Zobrazit plný text záznamu

Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers

Autor: M Paumen, Hidetoshi Inoko, Y Hayashi, Eri Kikkawa, Yuki Ozaki, Shingo Suzuki, Takeji Umemura, O Takahashi, Satoru Joshita, H Taira, Takashi Shiina, Atsuko Shigenari, Yoshihiko Katsuyama, Masao Ota, Shigeki Mitsunaga, Akira Oka, Jerzy K. Kulski

Publikováno v: Tissue Antigens. 80:305-316

Current human leukocyte antigen (HLA) DNA typing methods such as the sequence-based typing (SBT) and sequence-specific oligonucleotide (SSO) methods generally yield ambiguous typing results because of oligonucleotide probe design limitations or phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ba5e8fde1869e8cefc97c8917e97866
https://doi.org/10.1111/j.1399-0039.2012.01941.x

Zobrazit plný text záznamu

Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A*24:02: the same deletion observed in other A*24 alleles and A*23:01 allele

Autor: Shigeki Mitsunaga, Yuko Okudaira, Kazuyoshi Hosomichi, Tailin Cui, Shinji Sato, Akira Oka, Yasuhiko Homma, Nanae Kunii, Ituro Inoue, Hidetoshi Inoko, Yasuo Suzuki

Publikováno v: Immunogenetics. 63:467-474

In a structural aberration analysis of patients with arthritis mutilans, a 50 kb deletion near the HLA-A locus with HLA-A*24:02 allele was detected. It was previously reported that HLA-A*24:02 haplotype harbored a large-scale deletion telomeric of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aef0552ef6827ba5d76b02307826b5
https://doi.org/10.1007/s00251-011-0521-0

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání