Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Shigeki Kuwahara"'
Autor:
Shigeki Kuwahara, Atsuyuki Ashimori, Norifumi Nakamura, Takuya Yoshimura, Mizuo Miyazaki, Masahide Nakajima, Fumihiko Akahoshi, Naoko Mitsutomi, Chikara Fukaya, Tatsuyuki Ohtsuka, Teruaki Imada
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:301-315
Chymase possesses a wide variety of actions, including promotion of angiotensin II production and histamine release from mast cells. However, due to a lack of effective inhibitors featuring both high inhibitory activity and high metabolic stability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa83dca04f71e0e7e772d578254b8ac4
https://doi.org/10.1016/s0968-0896(00)00244-3
https://doi.org/10.1016/s0968-0896(00)00244-3
Autor:
N. Sugiyama, Shigeki Kuwahara, Fumihiko Akahoshi, Chikara Fukaya, Yoshiko Sakaue, Masahiko Kajii, Masanori Sugiura, Haruko Yakumaru
Publikováno v:
Journal of Medicinal Chemistry. 37:1977-1982
In order to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities, a series of o-aminophenol derivatives bearing H1-antihistaminic structures were synthesized and their effects were investigated on lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70de42842df8cf4b7b80f0886520fa5
https://doi.org/10.1021/jm00039a010
https://doi.org/10.1021/jm00039a010
Autor:
Masahiko Kajii, Yoshiko Sakaue, Chikara Fukaya, Shigeki Kuwahara, N. Sugiyama, Fumihiko Akahoshi, Masanori Sugiura, Haruko Yakumaru
Publikováno v:
ChemInform. 25
In order to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities, a series of o-aminophenol derivatives bearing H 1 -antihistaminic structures were synthesized and their effects were investigated on l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::606a722c6d81e60a5f77ccf2978965d2
https://doi.org/10.1002/chin.199450165
https://doi.org/10.1002/chin.199450165
Autor:
Shigeki Kuwahara, Hiroshi Sakashita, Takao Kondo, Shinichiro Ono, Masahiro Takeuchi, Youichiro Naito
Publikováno v:
ChemInform. 31
We report the syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Among the compounds we evaluated, 1,5-Bis[4-(5-amidinobenzofuran-2-ylcarbonyl)piperazinylcarbonylmethoxy]cyclooctane 26 (AY0068) was found to be a selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0beff5226469bfdd4aef160aafc46faf
https://doi.org/10.1002/chin.200009241
https://doi.org/10.1002/chin.200009241
Autor:
Shigeki Kuwahara, Masanori Sugiura, Hiroko Nishimura, Chikara Fukaya, Masahiko Kajii, K. Yokoyama, J. Wada, N. Sugiyama, K. Yamanouchi
Publikováno v:
Agents and Actions. 41:C216-C218
A recent investigation has indicated that reactive oxygen species (ROS) may play an important role in the activation of lymphocytes. The main aim of the present study is to find out what effect on lymphocyte activation is attributable to radical scav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d762ab7621ca294b87b16c0dc5339a1
https://doi.org/10.1007/bf01987643
https://doi.org/10.1007/bf01987643
Autor:
Tatsuyuki Ohtsuka, Mizuo Miyazaki, Teruaki Imada, Chikara Fukaya, Fumihiko Akahoshi, Hiroshi Sakashita, Shigeki Kuwahara, Masahide Nakajima, Naoko Mitsutomi, Norifumi Nakamura, Takuya Yoshimura, Atsuyuki Ashimori
Publikováno v:
Journal of medicinal chemistry. 44(8)
We designed nonpeptidic chymase inhibitors based on the structure of a peptidic compound (1) and demonstrated that the combination of a pyrimidinone skeleton as a P3-P2 scaffold and heterocycles as P1 carbonyl-activating groups can function as a nonp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4723bfcae1dbbdf028570e12c3833e
https://pubmed.ncbi.nlm.nih.gov/11312927
https://pubmed.ncbi.nlm.nih.gov/11312927
Autor:
Masahide Nakajima, Naoko Mitsutomi, Fumihiko Akahoshi, Atsuyuki Ashimori, Mizuo Miyazaki, Masahiro Eda, Teruaki Imada, Norifumi Nakamura, Hiroshi Sakashita, Takuya Yoshimura, Tatsuyuki Ohtsuka, Chikara Fukaya, Shigeki Kuwahara
Publikováno v:
Journal of medicinal chemistry. 44(8)
Potent human chymase inhibitors with high enzymatic selectivity and satisfactory metabolic stability were obtained by replacing the Val-Pro (P3-P2) dipeptide portion of the previously described inhibitor 1 with a nonpeptidic pyrimidinone skeleton. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf027a53f899639c4007dddf00e52c08
https://pubmed.ncbi.nlm.nih.gov/11312928
https://pubmed.ncbi.nlm.nih.gov/11312928
Autor:
Mizuo Miyazaki, Norifumi Nakamura, Koji Naito, Tsutomu Yoshikawa, Naruyasu Komorita, Teruaki Imada, Fujio Kobayashi, Takao Kondo, Shigeki Kuwahara
Publikováno v:
Journal of Allergy and Clinical Immunology. 105:S267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bd1ce0c2905af7ab298da635276762
https://doi.org/10.1016/s0091-6749(00)91220-x
https://doi.org/10.1016/s0091-6749(00)91220-x
Autor:
Kohji Yamamoto, Shigeki Kuwahara, Masahiro Watanabe, Kazumasa Yokoyama, Chikara Fukaya, Tsutomu Mimura, Masaru Okabe, Yasuhiro Kohama
Publikováno v:
Chemical and Pharmaceutical Bulletin. 36:4597-4599
The present investigation was done to examine whether or not the presence of hydroxyproline in N-3-(4-hydroxyphenyl) propionyl Pro-Hyp-Gly-Ala-Gly (HP-5) is essential for the antiarrhythmic activity. Pretreatment of mice with 10 mg/kg of [Pro2]-HP-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6c57930ee2a615d6b18b6230aade8f
https://doi.org/10.1248/cpb.36.4597
https://doi.org/10.1248/cpb.36.4597
Autor:
Shigeki Kuwahara, Masayoshi Kinoshita, Masahiro Watanabe, Mitsuyoshi Hihara, Takao Kondo, Kiyoshi Yamauchi
Publikováno v:
Bulletin of the Chemical Society of Japan. 62:969-971
A dimer of platelet activating factor (PAF), 1,1′-(1,32-dotriacontanediyl)bis[2-acetyl-sn-glycero(3)phosphocholine] (7), was synthesized and examined for platelet aggregation and antihypertension activities. The compound 7 showed both activities wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc29907d3ffe1693d14fb246e187862
https://doi.org/10.1246/bcsj.62.969
https://doi.org/10.1246/bcsj.62.969